Listar Química Orgánica por agencia financiadora "Ministerio de Ciencia e Innovación (MICIN). España"
Mostrando ítems 1-20 de 47
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Artículo
A Bicyclic 1-Deoxygalactonojirimycin Derivative as a Novel Pharmacological Chaperone for GM1 Gangliosidosis
(Cell Press, 2013)Lysosomal β-galactosidase (β-Gal) deficiency causes a group of disorders that include neuronopathic GM1 gangliosidosis and ...
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A Complex Regulatory Network Governs the Expression of Symbiotic Genes in Sinorhizobium Fredii HH103
(Frontiers Media, 2023)Introduction: The establishment of the rhizobium-legume nitrogen-fixing symbiosis relies on the interchange of molecular ...
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A hybrid of 1-deoxynojirimycin and benzotriazole induces preferential inhibition of butyrylcholinesterase (BuChE) over acetylcholinesterase (AChE).
(Taylor and Francis Group, 2022)The synthesis of four heterodimers in which the copper(I)-catalysed azide-alkyne cycloaddition wasemployed to connect a ...
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A versatile stereocontrolled synthesis of 2-deoxyiminosugarC-glycosides and their evaluation as glycosidase inhibitors
(Royal Society of Chemistry, 2021)A highly enantioselective synthesis of (R,S) or (S,S)-2,6-disubstituted dehydropiperidines has been previously achieved ...
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Asymmetric synthesis of dibenzo[b,d]azepines by Cu-catalyzed reductive or borylative cyclization
(Royal Society of Chemistry, 2021)A copper-catalyzed asymmetric intramolecular reductive cyclization for the synthesis of dibenzo[b,d]azepines is described. ...
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Artículo
Bicyclic (galacto)nojirimycin analogues as glycosidase inhibitors: Effect of structural modifications in their pharmacological chaperone potential towards β-glucocerebrosidase
(Royal Society of Chemistry (Great Britain), 2011)A molecular-diversity-oriented approach for the preparation of bicyclic sp2-iminosugar glycomimetics related to nojirimycin ...
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Biocatalytic Atroposelective Synthesis of Axially Chiral N-Arylindoles via Dynamic Kinetic Resolution
(American Chemical Society, 2022-12-22)A highly enantioselective biocatalytic dynamic kinetic resolution (DKR) of configurationally labile N-arylindole aldehydes ...
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Artículo
Biotinylated selenocyanates: Potent and selective cytostatic agents
(Elsevier, 2023-04)Most of the currently available cytotoxic agents for tackling cancer are devoid of selectivity, thus causing severe ...
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Artículo
Bis-borylated arylisoquinoline-derived dyes with a central aromatic core: towards efficient fluorescent singlet-oxygen photosensitizers
(Royal Society of Chemistry, 2022)Conveniently modified polycyclic aromatic hydrocarbon (PAH) fluorophores are obtained by a bromination–borylation sequence. ...
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Carbohydrate-derived bicyclic selenazolines as new dual inhibitors (cholinesterases/OGA) against Alzheimer's disease
(Elsevier, 2022-10)Concerned by the urgent need to explore new approaches for the treatment of Alzheimer's disease, we herein describe the ...
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Conformationally Restricted Glycoconjugates Derived from Arylsulfonamides and Coumarins: New Families of Tumour-Associated Carbonic Anhydrase Inhibitors
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)The involvement of carbonic anhydrases (CAs) in a myriad of biological events makes the development of new inhibitors of ...
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Cyclodextrin-Based Functional Glyconanomaterials
(MDPI, 2020-12)Cyclodextrins (CDs) have long occupied a prominent position in most pharmaceutical laboratories as “off-the-shelve” tools ...
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Cyclodextrin-mediated Crystallization of Acid β-glucosidase in Complex with Amphiphilic Bicyclic Nojirimycin Analogues
(Royal Society of Chemistry, 2011)Cyclodextrin-based host-guest chemistry has been exploited to facilitate co-crystallization of recombinant human acid ...
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Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase
(Taylor & Francis Open Access, 2021)The synthesis of four tetra-tacrine clusters where the tacrine binding units are attached to a central scaffold via linkers ...
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Discovery of human hexosaminidase inhibitors by in situ screening of a library of mono- and divalent pyrrolidine iminosugars
(Elsevier, 2022)Two libraries of mono- and dimeric pyrrolidine iminosugars were synthesized by CuAAC and (thio)urea-bond-forming reactions ...
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Effects of inulin and di-d-fructose dianhydride-enriched caramels on intestinal microbiota composition and performance of broiler chickens
(Elsevier, 2013)In vitro and in vivo experiments were designed to evaluate the effectiveness of laboratory-made di-d-fructose dianhydride ...
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Enhanced Gene Delivery Triggered by Dual pH/Redox Responsive Host-Guest Dimerization of Cyclooligosaccharide Star Polycations
(Wiley, 2022)A robust strategy is reported to build perfectly monodisperse star polycationscombining a trehalose-based cyclooligosaccharide ...
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Exopolysaccharide Production by Sinorhizobium fredii HH103 Is Repressed by Genistein in a NodD1-Dependent Manner
(Public Library of Science, 2016)In the rhizobia-legume symbiotic interaction, bacterial surface polysaccharides, such as exopolysaccharide (EPS), ...
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Experimental and Theoretical Analysis of the Thiol-Promoted Fragmentation of 2-Halo-3-tosyl-oxanorbornadienes
(American Chemical Society, 2023)2-Halo-3-tosyl-oxanorbornadienes are able to accept two thiol molecules through an initial nucleophilic substitution, ...
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Fluoro-labelled sp2-iminoglycolipids with immunomodulatory properties
(Elsevier, 2023)The unique electronic properties of the fluorine atom make its strategic incorporation into a bioactive compound a very ...