Browsing Química Orgánica by Funding agency "Ministerio de Ciencia e Innovación (MICIN). España"
Now showing items 1-20 of 63
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Article
A Bicyclic 1-Deoxygalactonojirimycin Derivative as a Novel Pharmacological Chaperone for GM1 Gangliosidosis
(Cell Press, 2013)Lysosomal β-galactosidase (β-Gal) deficiency causes a group of disorders that include neuronopathic GM1 gangliosidosis and ...
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Article
A Complex Regulatory Network Governs the Expression of Symbiotic Genes in Sinorhizobium Fredii HH103
(Frontiers Media, 2023)Introduction: The establishment of the rhizobium-legume nitrogen-fixing symbiosis relies on the interchange of molecular ...
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Article
A hybrid of 1-deoxynojirimycin and benzotriazole induces preferential inhibition of butyrylcholinesterase (BuChE) over acetylcholinesterase (AChE).
(Taylor and Francis Group, 2022)The synthesis of four heterodimers in which the copper(I)-catalysed azide-alkyne cycloaddition wasemployed to connect a ...
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Article
A Multitarget Approach against Neuroinflammation: Alkyl Substituted Coumarins as Inhibitors of Enzymes Involved in Neurodegeneration
(MDPI, 2023-11-25)Neurodegenerative disorders (NDs) include a large range of diseases characterized by neural dysfunction with a multifactorial ...
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Article
A versatile stereocontrolled synthesis of 2-deoxyiminosugarC-glycosides and their evaluation as glycosidase inhibitors
(Royal Society of Chemistry, 2021)A highly enantioselective synthesis of (R,S) or (S,S)-2,6-disubstituted dehydropiperidines has been previously achieved ...
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Article
Asymmetric Dearomatization of Phthalazines by Anion-BindingCatalysis
(American Chemical Society, 2023-12-01)A straightforward methodology for the enantioselective synthesis of 1,2-dihydrophthalazines via dearomatization of ...
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Article
Asymmetric Synthesis of Axially Chiral C N Atropisomers
(Wiley, 2022)Molecules with restricted rotation around a single bond or atropisomers are found in a wide number of natural products ...
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Article
Asymmetric synthesis of dibenzo[b,d]azepines by Cu-catalyzed reductive or borylative cyclization
(Royal Society of Chemistry, 2021)A copper-catalyzed asymmetric intramolecular reductive cyclization for the synthesis of dibenzo[b,d]azepines is described. ...
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Article
Atroposelective Synthesis of 2-(Quinolin-8-yl)benzyl Alcohols by Biocatalytic Dynamic Kinetic Resolutions
(Wiley, 2023-12-22)A highly enantioselective biocatalytic dynamic kinetic resolution (DKR) of 2-(quinoline-8-yl) 3-methylbenzaldehydes and ...
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Article
Azaborahelicene fluorophores derived from four-coordinate N,C-boron chelates: synthesis, photophysical and chiroptical properties
(Royal Society of Chemistry, 2023-12-12)A series of six azaborahelicenes with varying electron-donor substitution at the 4-position of the aryl residue (i.e., ...
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Article
Bicyclic (galacto)nojirimycin analogues as glycosidase inhibitors: Effect of structural modifications in their pharmacological chaperone potential towards β-glucocerebrosidase
(Royal Society of Chemistry (Great Britain), 2011)A molecular-diversity-oriented approach for the preparation of bicyclic sp2-iminosugar glycomimetics related to nojirimycin ...
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Article
Biocatalytic Atroposelective Synthesis of Axially Chiral N-Arylindoles via Dynamic Kinetic Resolution
(American Chemical Society, 2022-12-22)A highly enantioselective biocatalytic dynamic kinetic resolution (DKR) of configurationally labile N-arylindole aldehydes ...
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Article
Biotinylated selenocyanates: Potent and selective cytostatic agents
(Elsevier, 2023-04)Most of the currently available cytotoxic agents for tackling cancer are devoid of selectivity, thus causing severe ...
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Article
Bis-borylated arylisoquinoline-derived dyes with a central aromatic core: towards efficient fluorescent singlet-oxygen photosensitizers
(Royal Society of Chemistry, 2022)Conveniently modified polycyclic aromatic hydrocarbon (PAH) fluorophores are obtained by a bromination–borylation sequence. ...
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Article
Carbohydrate-derived bicyclic selenazolines as new dual inhibitors (cholinesterases/OGA) against Alzheimer's disease
(Elsevier, 2022-10)Concerned by the urgent need to explore new approaches for the treatment of Alzheimer's disease, we herein describe the ...
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Article
Conformationally Restricted Glycoconjugates Derived from Arylsulfonamides and Coumarins: New Families of Tumour-Associated Carbonic Anhydrase Inhibitors
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)The involvement of carbonic anhydrases (CAs) in a myriad of biological events makes the development of new inhibitors of ...
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Article
Continuous flow synthesis of PCN-222 (MOF-545) with controlled size and morphology: a sustainable approach for efficient production
(Royal Society of Chemistry, 2023-11-21)Zirconium-based MOFs, such as PCN-222 (MOF-545), have gained attention due to their regular porosity, tuneable pore size, ...
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Article
Coumarins-lipophilic cations conjugates: Efficient mitocans targeting carbonic anhydrases
(Elsevier, 2024-02-13)Being aware of the need to develop more efficient therapies against cancer, herein we disclose an innovative approach for ...
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Article
Cyclodextrin-Based Functional Glyconanomaterials
(MDPI, 2020-12)Cyclodextrins (CDs) have long occupied a prominent position in most pharmaceutical laboratories as “off-the-shelve” tools ...
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Article
Cyclodextrin-mediated Crystallization of Acid β-glucosidase in Complex with Amphiphilic Bicyclic Nojirimycin Analogues
(Royal Society of Chemistry, 2011)Cyclodextrin-based host-guest chemistry has been exploited to facilitate co-crystallization of recombinant human acid ...