Buscar
Mostrando ítems 41-50 de 96
Artículo
Efficacy of Fosfomycin and Its Combination With Aminoglycosides in an Experimental Sepsis Model by Carbapenemase-Producing Klebsiella pneumoniae Clinical Strains
(Frontiers Media, 2021)
Carbapenemase-producing Klebsiella pneumoniae infections are an increasing global threat with scarce and uncertain treatment options. In this context, combination therapies are often used for these infections. The bactericidal ...
Artículo
In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC
(American Society for Microbiology, 2011-03-01)
This article provides an analysis of the in vitro effect of qnrA1, qnrB1, and qnrS1 genes, combined with quinolone-resistant Ser83Leu substitutions in GyrA and/or Ser80Arg in ParC, on fluoroquinolone (FQ) resistance in ...
Artículo
Energy-dependent accumulation of norfloxacin and porin expression in clinical isolates of Klebsiella pneumoniae and relationship to extended-spectrum β-lactamase production
(American Society for Microbiology, 2002-12-01)
The relationships between porin deficiency, active efflux of fluoroquinolones, and extended-spectrum β-lactamase (ESBL) production were determined for 53 clinical isolates of Klebsiella pneumoniae. Thirty-two ESBL-positive ...
Artículo
Pharmacodynamics of fosfomycin: Insights into clinical use for antimicrobial resistance
(American Society for Microbiology, 2015-09-01)
The aim of this study was to improve the understanding of the pharmacokinetic-pharmacodynamic relationships of fosfomycin against extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli strains that have different ...
Artículo
β-Lactam/β-Lactam Inhibitor Combinations for the Treatment of Bacteremia Due to Extended-Spectrum β-Lactamase-Producing Escherichia coli: A Post Hoc Analysis of Prospective Cohorts
(Oxford University Press, 2012)
Background. Extended-spectrum ß-lactamase–producing Escherichia coli (ESBL-EC) is an important cause of invasive infections. Alternatives to carbapenems—considered the drugs of choice—are needed because of the emergence ...
Artículo
Duration of Colonization by Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae in Healthy Newborns and Associated Risk Factors: a Prospective Cohort Study
(Oxford University Press, 2018)
Duration of colonization by extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) and factors associated with it were studied in 20 newborns in Seville, Spain. Median duration of colonization was 7.5 months; ...
Artículo
Is reduced vancomycin susceptibility a factor associated with poor prognosis in MSSA bacteraemia?
(Oxford University Press, 2015)
Objectives: The known data about the influence of vancomycin MIC on Staphylococcus aureus bacteraemia are contradictory. Our objective was to study the possible impact of vancomycin MIC ≥1.5 mg/L on short- and medium-term ...
Artículo
Uptake and intracellular activity of moxifloxacin in human neutrophils and tissue-cultured epithelial cells
(American Society for Microbiology, 1999-02-15)
The penetration by moxifloxacin of human neutrophils (polymorphonuclear leukocytes [PMN]) and tissue-cultured epithelial cells (McCoy cells) was evaluated by a fluorometric assay. At extracellular concentrations of 5 ...
Artículo
Fatal levofloxacin failure in treatment of a bacteremic patient infected with Streptococcus pneumoniae with a preexisting parC mutation
(American Society for Microbiology, 2008)
The fatal outcome of levofloxacin treatment in a patient with bacteremic pneumonia caused by Streptococcus pneumoniae with a preexisting parC mutation is reported. Failure was due to the emergence of a gyrA mutation after ...
Artículo
Epidemiology and Clinical Features of Infections Caused by Extended-Spectrum Beta-Lactamase-Producing Escherichia coli in Nonhospitalized Patients
(American Society for Microbiology, 2004-03)
Infections due to extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (ESBLEC) in nonhospitalize patients seem to be emerging in different countries. Their incidence, epidemiology, and clinical impact in the ...