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Artículo
Reelin expression is up-regulated in mice colon in response to acute colitis and provides resistance against colitis
(Elsevier, 2017)
Reelin is an extracellular matrix protein first known for its key role in neuronal migration. Studies in rodent small intestine suggested that reelin protects the organism from intestinal pathology. Here we determined in ...
Artículo
Cross Talk between Adipose Tissue and Placenta in Obese and Gestational Diabetes Mellitus Pregnancies via Exosomes
(Frontiers Media, 2017)
Obesity is an important public health issue worldwide, where it is commonly associated with the development of metabolic disorders, especially insulin resistance (IR). Maternal obesity is associated with an increased risk ...
Artículo
Mechanisms underlying the cardiac antifibrotic effects of losartan metabolites
(Nature Publishing Group:, 2017)
Excessive myocardial collagen deposition and cross-linking (CCL), a process regulated by lysyl oxidase (LOX), determines left ventricular (LV) stiffness and dysfunction. The angiotensin II antagonist losartan, metabolized ...
Tesis Doctoral
Efectos del estrés oxidativo sobre la excitabilidad de las neuronas piramidales de la corteza motora.
(2017-11-14)
El estrés oxidativo y la producción de especies reactivas de oxígeno (ROS) juegan un papel muy importante en el daño neuronal. Numerosas evidencias apuntan a que contribuyen a la degeneración neuronal que subyace a muchas ...
Artículo
Excitability is increased in hippocampal CA1 pyramidal cells of Fmr1 knockout mice
(Public Library of Science, 2017)
Fragile X syndrome (FXS) is caused by a failure of neuronal cells to express the gene encoding the fragile mental retardation protein (FMRP). Clinical features of the syndrome include intellectual disability, learning ...
Tesis Doctoral
Artículo
Importancia curricular de los estudios de bioética en la formación de especialistas en biotecnología animal
(Universitat Autònoma de Barcelona, 2017)
El presente proyecto docente incorpora para el alumnado del grado en Bioquímica de la Facultad de Biología de Sevilla, contenidos específicos de Bioética aplicados al campo de la Biotecnología animal. El objetivo de esta ...
Artículo
Maternal insulin therapy does not restore foetoplacental endothelial dysfunction in gestational diabetes mellitus
(Elsevier, 2017)
Pregnant women diagnosed with gestational diabetes mellitus subjected to diet (GDMd) that do not reach normal glycaemia are passed to insulin therapy (GDMi). GDMd associates with increased human cationic amino acid transporter ...
Tesis Doctoral
Aspectos tónicos y fásicos del sueño rem en la rata
(2017-09-08)
La identificación de variables y el análisis de los cambios de actividad en esas variables, ha constituido el principal abordaje para estudiar el ciclo vigilia-sueño. Durante el sueño, las variables más representativas han ...
Artículo
Reelin protects from colon pathology by maintaining the intestinal barrier integrity and repressing tumorigenic genes
(Elsevier, 2017)
We previously reported that reelin, an extracellular matrix protein first known for its key role in neuronal migration, reduces the susceptibility to dextran sulphate sodium (DSS)-colitis. The aim of the current study was ...