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Mostrando ítems 1-10 de 21
Artículo
Functional Diversity of Neurotrophin Actions on the Oculomotor System
(MDPI AG, 2016)
Neurotrophins play a principal role in neuronal survival and differentiation during development, but also in the maintenance of appropriate adult neuronal circuits and phenotypes. In the oculomotor system, we have demonstrated ...
Tesis Doctoral
Implante de progenitores neurales en un modelo de lesión del sistema oculomotor
(2015-11-11)
El implante de células progenitoras neurales en el sistema nervioso central lesionado es una poderosa herramienta reparadora. Sin embargo, aún no se han evaluado extensamente los efectos de dichos implantes sobre el patrón ...
Artículo
Vascular Endothelial Growth Factor (VEGF) Prevents the Downregulation of the Cholinergic Phenotype in Axotomized Motoneurons of the Adult Rat
(Frontiers Media, 2018)
Vascular endothelial growth factor (VEGF) was initially characterized by its activity on the vascular system. However, there is growing evidence indicating that VEGF also acts as a neuroprotective factor, and that its ...
Artículo
A Single Intraventricular Injection of VEGF Leads to Long-Term Neurotrophic Effects in Axotomized Motoneurons
(Society for Neuroscience, 2020)
Vascular endothelial growth factor (VEGF) has been recently demonstrated to induce neuroprotective and synaptotrophic effects on lesioned neurons. Hitherto, the administration of VEGF in different animal models of lesion ...
Artículo
Nerve Growth Factor Regulates the Firing Patterns and Synaptic Composition of Motoneurons
(Society for Neuroscience, 2010)
Target-derived neurotrophins exert powerful synaptotrophic actions in the adult brain and are involved in the regulation of different forms of synaptic plasticity. Target disconnection produces a profound synaptic stripping ...
Artículo
Short-term plasticity after partial deafferentation in the oculomotor system
(Springer Nature, 2019)
Medial rectus motoneurons are innervated by two main pontine inputs. The specific function of each of these two inputs remains to be fully understood. Indeed, selective partial deafferentation of medial rectus motoneurons, ...
Artículo
Effects of Selective Deafferentation on the Discharge Characteristics of Medial Rectus Motoneurons
(Society for Neuroscience, 2018)
Medial rectus motoneurons receive two main pontine inputs: abducens internuclear neurons, whose axons course through the medial longitudinal fasciculus (MLF), and neurons in the lateral vestibular nucleus, whose axons ...
Artículo
Neural Progenitor Cell Implants in the Lesioned Medial Longitudinal Fascicle of Adult Cats Regulate Synaptic Composition and Firing Properties of Abducens Internuclear Neurons
(Society for Neuroscience, 2014)
Transplants of neural progenitor cells (NPCs) into the injured CNS have been proposed as a powerful tool for brain repair, but, to date, few studies on the physiological response of host neurons have been reported. Therefore, ...
Artículo
Vascular endothelial growth factor: an essential neurotrophic factor for motoneurons?
(Medknow Publications, 2018)
Artículo
Extraocular motoneurons of the adult rat show higher levels of vascular endothelial growth factor and its receptor Flk-1 than other cranial motoneurons
(Public Library of Science, 2017)
Recent studies show a relationship between the deficit of vascular endothelial growth factor (VEGF) and motoneuronal degeneration, such as that occurring in amyotrophic lateral sclerosis (ALS). VEGF delivery protects ...