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The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2′-deoxycytidine lesions [Article]
(Oxford University Press, 2014)
Decitabine (5-aza-21-deoxycytidine, 5-azadC) is used in the treatment of Myelodysplatic syndrome (MDS) and Acute Myeloid Leukemia (AML). Its mechanism of action is thought to involve reactivation of genes implicated in ...