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Artículo
An approach to prospective primary school teachers' concept of environment and biodiversity through their design of educational itineraries: Validation of an evaluation rubric
(Multidisciplinary Digital Publishing Institute (MDPI), 2020)
The aim of this work is to promote outdoor activities to bring students closer to the environment and the biodiversity of their surroundings. In this sense, educational itineraries are a very good educational resource that ...
Artículo
A triple action CDK4/6-PI3K-BET inhibitor with augmented cancer cell cytotoxicity
(Springer Nature, 2020)
Artículo
CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes
(Springer Nature, 2021)
Proper chromosome segregation is essential to avoid aneuploidy, yet this process fails with increasing age in mammalian oocytes. Here we report a role for the scarcely described protein CENP-V in oocyte spindle formation ...
Tesis Doctoral
Estudio de la familia de proteínas Rho GTPasas en la biología del neuroblastoma
(2022-07-14)
El neuroblastoma (NB) es el tumor extracraneal sólido de aparición más común durante la edad pediátrica. El NB surge a raíz de un desarrollo erróneo del linaje simpatoadrenal de la cresta neural. Es una enfermedad muy ...
Artículo
Non-productive angiogenesis disassembles Aß plaque-associated blood vessels
(Springer Nature, 2021)
The human Alzheimer’s disease (AD) brain accumulates angiogenic markers but paradoxically, the cerebral microvasculature is reduced around Aß plaques. Here we demonstrate that angiogenesis is started near Aß plaques in ...
Artículo
EpiGraph: an open-source platform to quantify epithelial organization
(Oxford University Press, 2020)
Here we present EpiGraph, an image analysis tool that quantifies epithelial organization. Our method combines computational geometry and graph theory to measure the degree of order of any packed tissue. EpiGraph goes beyond ...
Ponencia
¿Qué intereses tiene el futuro maestro de educación primaria sobre las salidas fuera del aula?: una exploración de sus necesidades educativas
(Universidad de Córdoba, 2021)
La formación previa al practicum I, es un momento muy relevante para nuestro maestro de primaria en formación, en la que intentamos de resolver inquietudes, miedos y dudas sobre el periodo de prácticas. Desde el área de ...
Artículo
Arginine deprivation alters microglial polarity and synergizes with radiation to eradicate non-arginine-auxotrophic glioblastoma tumors
(American Society for Clinical Investigation, 2022)
New approaches for the management of glioblastoma (GBM) are an urgent and unmet clinical need. Here, we illustrate that the efficacy of radiotherapy for GBM is strikingly potentiated by concomitant therapy with the ...
Artículo
A protocol to enrich in undifferentiated cells from neuroblastoma tumor tissue samples and cell lines
(Cell Press, 2022)
The existence of a subpopulation of undifferentiated cells with stem-like properties has been suggested in neuroblastoma tumors, but a definitive biomarker for their successful isolation is missing. Here we describe an in ...
Artículo
An opinion on the regulation of bone marrow adipose tissue by dietary fatty acids
(CSIC, 2020)
Obesity has a significant impact on predisposition to various diseases and also affects the viability and choice of haematopoietic stem cells (HSCs) to favour myeloid cell production and/or turnover, all of which are ...