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Mostrando ítems 1-10 de 11
Artículo
Arginine deprivation alters microglial polarity and synergizes with radiation to eradicate non-arginine-auxotrophic glioblastoma tumors
(American Society for Clinical Investigation, 2022)
New approaches for the management of glioblastoma (GBM) are an urgent and unmet clinical need. Here, we illustrate that the efficacy of radiotherapy for GBM is strikingly potentiated by concomitant therapy with the ...
Artículo
An opinion on the regulation of bone marrow adipose tissue by dietary fatty acids
(CSIC, 2020)
Obesity has a significant impact on predisposition to various diseases and also affects the viability and choice of haematopoietic stem cells (HSCs) to favour myeloid cell production and/or turnover, all of which are ...
Artículo
Determination of the lipid composition of the GPI anchor
(PLOS, 2021)
In eukaryotic cells, a subset of cell surface proteins is attached by the glycolipid glycosylphosphatidylinositol (GPI) to the external leaflet of the plasma membrane where they play important roles as enzymes, receptors, ...
Ponencia
Effects of electrical fields on neuroblastoma (N2A) cell differentiation: preliminary results
(Scitepress, 2021)
This work describes Electrical Stimulations (ES) assays on stem cells. The neuroblastoma (N2A) cell linage was submitted to several electrical fields to enable and enhance its differentiation toward neurons. Both Direct ...
Artículo
A Role for Lipids in Protein Sorting?
(Swiss Chemical Society, 2021)
Lipid and protein diversity provides structural and functional identity to the membrane compartments that define the eukaryotic cell. This compositional heterogeneity is maintained by the secretory pathway, which feeds ...
Artículo
MUFAs in High-Fat Diets Protect against Obesity-Induced Bias of Hematopoietic Cell Lineages
(Wiley, 2021)
Scope: The role of dietary fatty acids in the generation of bone marrow (BM) immune cells and their trafficking to extramedullary compartments in the obesity is not yet fully understood. Methods and Results: C57BL/6J mice ...
Artículo
Structural analysis of the GPI glycan
(PLOS, 2021)
Glycosylphosphatidylinositol (GPI) anchoring of proteins is an essential post-translational modification in all eukaryotes that occurs at the endoplasmic reticulum (ER) and serves to deliver GPI-anchored proteins (GPI-APs) ...
Artículo
From Bioimpedance to Volume Estimation: A Model for Edema Calculus in Human Legs
(MDPI, 2023)
Heart failure (HF) is a severe disease and one of the most important causes of death in our society nowadays. A significant percentage of patients hospitalized for decompensation of heart failure are readmitted after ...
Artículo
Exogenous fatty acids and niacin on acute prostaglandin D-2 production in human myeloid cells
(Elsevier, 2017)
Niacin activates HCA2 receptor that results in the release of PGD2. However, little is known on PGD2-producing cells and the role of fatty acids. Notably M-CSF macrophages exhibited a timely dependent PGD2 production upon ...
Artículo
Loss of GATA4 causes ectopic pancreas in the stomach
(John Wiley & Sons, 2020-04)
Pancreatic heterotopia is defined as pancreatic tissue outside its normal location in the body and anatomically separated from the pancreas. In this work we have analyzed the stomach glandular epithelium of Gata4flox/flox; ...