dc.creator | Koch, Giacomo | es |
dc.creator | Porcacchia, Paolo | es |
dc.creator | Carrillo, Fátima | es |
dc.creator | Cáceres-Redondo, María Teresa | es |
dc.creator | Brusa, Livia | es |
dc.creator | Mir Rivera, Pablo | es |
dc.date.accessioned | 2021-04-27T13:50:56Z | |
dc.date.available | 2021-04-27T13:50:56Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Koch, G., Porcacchia, P., Carrillo, F., Cáceres-Redondo, M.T., Brusa, L. y Mir, P. (2014). Effects of Two Weeks of Cerebellar Theta Burst Stimulation in Cervical Dystonia Patients. Brain Stimulation, 7 (4), 564-572. | |
dc.identifier.issn | 1935-861X | es |
dc.identifier.uri | https://hdl.handle.net/11441/107967 | |
dc.description.abstract | Dystonia is generally regarded as a disorder of the basal ganglia and their efferent connections to the
thalamus and brainstem, but an important role of cerebellar-thalamo-cortical (CTC) circuits in the
pathophysiology of dystonia has been invoked. Here in a sham controlled trial, we tested the effects of
two-weeks of cerebellar continuous theta burst stimulation (cTBS) in a sample of cervical dystonia (CD)
patients. Clinical evaluations were performed by administering the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) and the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS). We used
TMS to measure the inhibitory connectivity between the cerebellum and the contralateral motor cortex
(cerebellar brain inhibition [CBI]), and the excitability of the contralateral primary motor cortex assessing
intracortical inhibition (SICI), intracortical facilitation (ICF) and cortical silent period (CSP). Paired
associative stimulation (PAS) was tested to evaluate the level and the topographical specificity of cortical
plasticity, which is abnormally enhanced and non-focal in CD patients. Two weeks of cerebellar stimulation resulted in a small but significant clinical improvement as measured by the TWSTRS of approximately 15%. Cerebellar stimulation modified the CBI circuits and reduced the heterotopic PAS
potentiation, leading to a normal pattern of topographic specific induced plasticity. These data provide
novel evidence CTC circuits could be a potential target to partially control some dystonic symptoms in
patients with cervical dystonia. | es |
dc.format | application/pdf | es |
dc.format.extent | 9 p. | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | Brain Stimulation, 7 (4), 564-572. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Cerebellar-thalamo-cortical circuits | es |
dc.subject | Cervical dystonia | es |
dc.subject | Cerebellar theta burst stimulation | es |
dc.subject | Paired associative stimulation | es |
dc.title | Effects of Two Weeks of Cerebellar Theta Burst Stimulation in Cervical Dystonia Patients | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | https://reader.elsevier.com/reader/sd/pii/S1935861X14001727?token=C29178DBBB2B852B52D9FC9C1FB034D85ECC474A544A5BAE0FC5B52F2DB071D94CBB251343DC5EA71B2A08A73714F80A&originRegion=eu-west-1&originCreation=20210427133645 | es |
dc.identifier.doi | 10.1016/j.brs.2014.05.002 | es |
dc.journaltitle | Brain Stimulation | es |
dc.publication.volumen | 7 | es |
dc.publication.issue | 4 | es |
dc.publication.initialPage | 564 | es |
dc.publication.endPage | 572 | es |