Article
Post-Translational Modifications of Cytochrome c in Cell Life and Disease
Author/s | Guerra Castellano, Alejandra
Márquez Escudero, Inmaculada Pérez Mejías, Gonzalo Díaz Quintana, Antonio Jesús Rosa Acosta, Miguel Ángel de la Díaz Moreno, Irene |
Department | Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular |
Publication Date | 2020 |
Deposit Date | 2021-04-19 |
Published in |
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Abstract | Mitochondria are the powerhouses of the cell, whilst their malfunction is related to several
human pathologies, including neurodegenerative diseases, cardiovascular diseases, and various
types of cancer. In mitochondrial ... Mitochondria are the powerhouses of the cell, whilst their malfunction is related to several human pathologies, including neurodegenerative diseases, cardiovascular diseases, and various types of cancer. In mitochondrial metabolism, cytochrome c is a small soluble heme protein that acts as an essential redox carrier in the respiratory electron transport chain. However, cytochrome c is likewise an essential protein in the cytoplasm acting as an activator of programmed cell death. Such a dual role of cytochrome c in cell life and death is indeed fine-regulated by a wide variety of protein post-translational modifications. In this work, we show how these modifications can alter cytochrome c structure and functionality, thus emerging as a control mechanism of cell metabolism but also as a key element in development and prevention of pathologies |
Funding agencies | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) Junta de Andalucía |
Project ID. | PGC2018-096049-B-I00
BIO-198, US-1254317, US-1257019 and P18-FR-3487 |
Citation | Guerra Castellano, A., Márquez Escudero, I., Pérez Mejías, G., Díaz Quintana, A.J., Rosa Acosta, M.Á.d.l. y Díaz Moreno, I. (2020). Post-Translational Modifications of Cytochrome c in Cell Life and Disease. International Journal of Molecular Science, 21 (22), 8483. |
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