ListarInvestigación por materia "R-loops"
Mostrando ítems 1-12 de 12
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A role for the Saccharomyces cerevisiae Rtt109 histone acetyltransferase in R-loop homeostasis and associated genome instability
(Genetics Society of America, 2022)The stability of the genome is occasionally challenged by the formation of DNA-RNA hybrids and R-loops, which can be ...
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Activation-induced cytidine deaminase action is strongly stimulated by mutations of the THO complex
(National Academy of Sciences, 2007)Activation-induced cytidine deaminase (AID) is a B cell enzyme essential for Ig somatic hypermutation and class switch ...
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BRCA2 promotes DNA-RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair
(Wiley-Blackwell, 2021)The BRCA2 tumor suppressor is a DNA double-strand break (DSB) repair factor essential for maintaining genome integrity. ...
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Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability
(Elsevier, 2019)Although correlations between RNA polymerase II (RNAPII) transcription stress, R-loops, and genome instability have been ...
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Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways
(Shared Science Publishers OG, 2019)Understanding the plasticity of genomes has been greatly aided by assays for recombination, repair and mutagenesis. These ...
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Harmful DNA:RNA hybrids are formed in cis and in a Rad51-independent manner
(eLife Sciences Publications, 2020)DNA:RNA hybrids constitute a well-known source of recombinogenic DNA damage. The current literature is in agreement with ...
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The antitumor drugs trabectedin and lurbinectedin induce transcription-dependent replication stress and genome instability
(American Association for Cancer Research, 2019)R-loops are a major source of replication stress, DNA damage, and genome instability, which are major hallmarks of cancer ...
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The effect of atypical nucleic acids structures in DNA double strand break repair: a tale of R-loops and G-quadruplexes
(Frontiers Media S.A., 2021)The fine tuning of the DNA double strand break repair pathway choice relies on different regulatory layers that respond ...
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The role of chromatin at transcription-replication conflicts as a genome safeguard
(Portland Press, 2021)DNA replication ensures the correct copying of the genome and the faithful transfer of the genetic information to the ...
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The SWI/SNF chromatin remodeling complex helps resolve R-loop-mediated transcription–replication conflicts
(Springer Nature, 2021)ATP-dependent chromatin remodelers are commonly mutated in human cancer. Mammalian SWI/SNF complexes comprise three conserved ...
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The SWI/SNF complex, transcription-replication conflicts and cancer: a connection with high therapeutic potential
(Taylor & Francis, 2021)Genome instability is a hallmark of cancer. ATP-dependent chromatin remodelers are frequently altered in cancer. We have ...
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What causes an RNA-DNA hybrid to compromise genome integrity?
(Elsevier, 2019)Transcription is a source of genome instability that stimulates mutation and recombination. Part of the damage produced ...