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dc.creatorYin, Xiaochanges
dc.creatorRomero Campero, Francisco Josées
dc.creatorReyes Rodríguez, Pedro de loses
dc.creatorYan, Penges
dc.creatorYang, Jinges
dc.creatorTian, Guangmeies
dc.creatorYang, Xiao Zenges
dc.creatorMo, Xiaoronges
dc.creatorZhao, Shuangshuanges
dc.creatorCalonje Macaya, Miriames
dc.creatorZhou, Yuees
dc.date.accessioned2021-02-12T15:48:06Z
dc.date.available2021-02-12T15:48:06Z
dc.date.issued2021
dc.identifier.citationYin, X., Romero Campero, F.J., Reyes Rodríguez, P.d.l., Yan, P., Yang, J., Tian, G.,...,Zhou, Y. (2021). H2AK121ub in Arabidopsis associates with a less accessible chromatin state at transcriptional regulation hotspots. Nature Communications, 12 (1), 315.
dc.identifier.issn2041-1723es
dc.identifier.urihttps://hdl.handle.net/11441/104919
dc.description.abstractAlthough it is well established that the Polycomb Group (PcG) complexes maintain gene repression through the incorporation of H2AK121ub and H3K27me3, little is known about the effect of these modifications on chromatin accessibility, which is fundamental to understand PcG function. Here, by integrating chromatin accessibility, histone marks and expression analyses in different Arabidopsis PcG mutants, we show that PcG function regulates chromatin accessibility. We find that H2AK121ub is associated with a less accessible but still permissive chromatin at transcriptional regulation hotspots. Accessibility is further reduced by EMF1 acting in collaboration with PRC2 activity. Consequently, H2AK121ub/H3K27me3 marks are linked to inaccessible although responsive chromatin. In contrast, only-H3K27me3-marked chromatin is less responsive, indicating that H2AK121ub-marked hotspots are required for transcriptional responses. Nevertheless, despite the loss of PcG activities leads to increased chromatin accessibility, this is not necessarily accompanied by transcriptional activation, indicating that accessible chromatin is not always predictive of gene expression.es
dc.description.sponsorshipNational Natural Science Foundation of China 31970532es
dc.description.sponsorshipMinisterio de Ciencia e Innovación BIO2016-76457-P, PID2019-106664GB-I00, BIO2017-84066-Res
dc.formatapplication/pdfes
dc.format.extent12 p.es
dc.language.isoenges
dc.publisherSpringer Naturees
dc.relation.ispartofNature Communications, 12 (1), 315.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleH2AK121ub in Arabidopsis associates with a less accessible chromatin state at transcriptional regulation hotspotses
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Ciencias de la Computación e Inteligencia Artificiales
dc.relation.projectID31970532es
dc.relation.projectIDBIO2016-76457-Pes
dc.relation.projectIDPID2019-106664GB-I00es
dc.relation.projectIDBIO2017-84066-Res
dc.relation.publisherversionhttp://dx.doi.org/10.1038/s41467-020-20614-1es
dc.identifier.doi10.1038/s41467-020-20614-1es
dc.journaltitleNature Communicationses
dc.publication.volumen12es
dc.publication.issue1es
dc.publication.initialPage315es

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