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Artículo
DNA-RNA hybrids: The risks of DNA breakage during transcription
dc.creator | Aguilera López, Andrés | es |
dc.creator | Gómez González, Belén | es |
dc.date.accessioned | 2020-10-02T17:08:49Z | |
dc.date.available | 2020-10-02T17:08:49Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Aguilera López, A. y Gómez González, B.M. (2017). DNA-RNA hybrids: The risks of DNA breakage during transcription. Nature Structural and Molecular Biology, 24 (5), 439-443. | |
dc.identifier.issn | 1545-9993 | es |
dc.identifier.issn | 1545-9985 | es |
dc.identifier.uri | https://hdl.handle.net/11441/101681 | |
dc.description.abstract | Although R loops can occur at different genomic locations, the factors that determine their formation and frequency remain unclear. Emerging evidence indicates that DNA breaks stimulate DNA-RNA hybrid formation. Here, we discuss the possibility that formation of hybrids may be an inevitable risk of DNA breaks that occur within actively transcribed regions. While such hybrids must be removed to permit repair, their potential role as repair intermediates remains to be established. | es |
dc.format | application/pdf | es |
dc.format.extent | 16 p. | es |
dc.language.iso | eng | es |
dc.publisher | Springer Nature | es |
dc.relation.ispartof | Nature Structural and Molecular Biology, 24 (5), 439-443. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | DNA-RNA hybrids: The risks of DNA breakage during transcription | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/submittedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Genética | es |
dc.relation.publisherversion | http://dx.doi.org/10.1038/nsmb.3395 | es |
dc.identifier.doi | 10.1038/nsmb.3395 | es |
dc.journaltitle | Nature Structural and Molecular Biology | es |
dc.publication.volumen | 24 | es |
dc.publication.issue | 5 | es |
dc.publication.initialPage | 439 | es |
dc.publication.endPage | 443 | es |
Ficheros | Tamaño | Formato | Ver | Descripción |
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DNA-RNA hybrids the risks of ... | 2.041Mb | [PDF] | Ver/ | |