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dc.creatorBernabeu Wittel, Máximoes
dc.creatorGómez Díaz, Raqueles
dc.creatorGonzález Molina, Alvaroes
dc.creatorVidal Serrano, Sofíaes
dc.creatorDíez-Manglano, Jesúses
dc.creatorSalgado, Fernandoes
dc.creatorSoto Martín, Maríaes
dc.creatorOllero Baturone, Manueles
dc.date.accessioned2020-09-18T15:59:30Z
dc.date.available2020-09-18T15:59:30Z
dc.date.issued2020-08-18
dc.identifier.citationBernabeu Wittel, M., Gómez Díaz, R., González Molina, A., Vidal Serrano, S., Díez-Manglano, J., Salgado, F.,...,Ollero Baturone, M. (2020). Oxidative Stress, Telomere Shortening, and Apoptosis Associated to Sarcopenia and Frailty in Patients with Multimorbidity. Journal of Clinical Medicine, 9 (2669), 1-12.
dc.identifier.issn2077-0383es
dc.identifier.urihttps://hdl.handle.net/11441/101316
dc.description.abstractThe presence of oxidative stress, telomere shortening, and apoptosis in polypathological patients (PP) with sarcopenia and frailty remains unknown. Methods: Multicentric prospective observational study in order to assess oxidative stress markers (catalase, glutathione reductase (GR), total antioxidant capacity to reactive oxygen species (TAC-ROS), and superoxide dismutase (SOD)), absolute telomere length (aTL), and apoptosis (DNA fragmentation) in peripheral blood samples of a hospital-based population of PP. Associations of these biomarkers to sarcopenia, frailty, functional status, and 12-month mortality were analyzed. Results: Of the 444 recruited patients, 97 (21.8%), 278 (62.6%), and 80 (18%) were sarcopenic, frail, or both, respectively. Oxidative stress markers (lower TAC-ROS and higher SOD) were significantly enhanced and aTL significantly shortened in patients with sarcopenia, frailty or both syndromes. No evidence of apoptosis was detected in blood leukocytes of any of the patients. Both oxidative stress markers (GR, p = 0.04) and telomere shortening (p = 0.001) were associated to death risk and to less survival days. Conclusions: Oxidative stress markers and telomere length were enhanced and shortened, respectively, in blood samples of polypathological patients with sarcopenia and/or frailty. Both were associated to decreased survival. They could be useful in the clinical practice to assess vulnerable populations with multimorbidity and of potential interest as therapeutic targets.es
dc.formatapplication/pdfes
dc.format.extent12 p.es
dc.language.isoenges
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMultimorbidityes
dc.subjectPolypathological patientses
dc.subjectSarcopeniaes
dc.subjectFrailtyes
dc.subjectOxidative stresses
dc.subjectTelomere lengthes
dc.subjectApoptosises
dc.titleOxidative Stress, Telomere Shortening, and Apoptosis Associated to Sarcopenia and Frailty in Patients with Multimorbidityes
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Medicinaes
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Fisiología Médica y Biofísicaes
dc.relation.publisherversiondoi:10.3390/jcm908266es
dc.journaltitleJournal of Clinical Medicinees
dc.publication.volumen9es
dc.publication.issue2669es
dc.publication.initialPage1es
dc.publication.endPage12es

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Except where otherwise noted, this item's license is described as: Attribution-NonCommercial-NoDerivatives 4.0 Internacional