Fisiología (Datos de investigación)
URI permanente para esta colecciónhttps://hdl.handle.net/11441/166303
Examinar
Envíos recientes
Conjunto de Datos Dataset of VEGF, but Not BDNF, Prevents the Downregulation of KCC2 Induced by Axotomy in Extraocular Motoneurons(2026-06) Capilla López, Jaime; García Hernández, Rosendo Miguel; Carrero Rojas, Génova; Martín Calvo, Paula; Álvarez, Francisco J.; Rodríguez de la Cruz, Rosa María; Pastor Loro, Ángel Manuel; Fisiología; Pastor Loro, Ángel Manuel; Capilla López, Jaime; Pastor Loro, Ángel Manuel; Ministerio de Ciencia, Innovación y Universidades (MICINN). España; Agencia Estatal de Investigación (AEI); National Institutes of Health (NIH). Estados Unidos; BIO297: Laboratorio de Fisiología y Plasticidad NeuronalThe potassium–chloride cotransporter KCC2 is the main extruder of Cl- in neurons. It plays a fundamental role in the activity of the inhibitory neurotransmitters (GABA and glycine) since low levels of KCC2 promote intracellular Cl- accumulation, leading to the depolarizing activity of GABA and glycine. The downregulation of this cotransporter occurs in neurological disorders characterized by hyperexcitability, such as epilepsy, neuropathic pain, and spasticity. KCC2 is also downregulated after axotomy. If muscle reinnervation is allowed, the KCC2 levels recover in motoneurons. Therefore, we argued that target-derived neurotrophic factors might be involved in the regulation of KCC2 expression. For this purpose, we performed the axotomy of extraocular motoneurons via the monocular enucleation of adult rats, and a pellet containing either VEGF or BDNF was chronically implanted in the orbit. Double confocal immunofluorescence of choline acetyl-transferase (ChAT) and KCC2 was carried out in the brainstem sections. Axotomy led to a KCC2 decrease in the neuropil and somata of extraocular motoneurons, peaking at 15 days post-lesion, with the exception of the abducens motoneuron somata. VEGF administration prevented the axotomy-induced KCC2 downregulation. By contrast, BDNF either maintained or reduced the KCC2 levels following axotomy, suggesting that BDNF is involved in the axotomy-induced KCC2 downregulation in extraocular motoneurons. The finding that VEGF prevents KCC2 decrease opens up new possibilities for the treatment of neurological disorders coursing with neuronal hyperactivity due to KCC2 downregulation.Conjunto de Datos Dataset of Relative contribution of lateral vestibular neuron and abducens internuclear neuron inputs to the discharge activity of medial rectus motoneurons(2026-05-25) García Hernández, Rosendo Miguel; Benítez Temiño, Beatriz; Rodríguez de la Cruz, Rosa María; Pastor Loro, Ángel Manuel; Fisiología; Pastor Loro, Ángel Manuel; García Hernández, Rosendo Miguel; Pastor Loro, Ángel Manuel; Ministerio de Educación y Ciencia (MEC). España; Junta de Andalucía; European Union (UE); BIO297: Laboratorio de Fisiología y Plasticidad NeuronalConjunto de Datos Dataset of Preservation of KCC2 expression in axotomized abducens motoneurons and its enhancement by VEGF(2026-06-26) Martín Calvo, Paula; Rodríguez de la Cruz, Rosa María; Pastor Loro, Ángel Manuel; Álvarez, Francisco J.; Fisiología; Pastor Loro, Ángel Manuel; Martín Calvo, Paula; Pastor Loro, Ángel Manuel; BIO297: Laboratorio de Fisiología y Plasticidad NeuronalConjunto de Datos Dataset of VEGF is an essential retrograde trophic factor for motoneurons(2026-06-23) Martín Calvo, Paula; García Hernández, Rosendo Miguel; Rodríguez de la Cruz, Rosa María; Pastor Loro, Ángel Manuel; Fisiología; Pastor Loro, Ángel Manuel; Martín Calvo, Paula; Pastor Loro, Ángel Manuel; Ministerio de Ciencia e Innovación (MICIN). España; Agencia Estatal de Investigación. España; European Union (UE); Junta de Andalucía; Ministerio de Educación y Ciencia (MEC). España; BIO297: Laboratorio de Fisiología y Plasticidad NeuronalConjunto de Datos Dataset from Protective mechanisms of wild olive (acebuche) oil in ARPE19 with hypertensive phenotype(2025-04-11) Santana Garrido, Álvaro; Reyes Goya, Claudia; Espinosa Martín, Pablo; Troya Toledo, Rosa María; André, Helder; Mate Barrero, Alfonso; Vázquez Cueto, Carmen María; Fisiología; Mate Barrero, Alfonso; Vázquez Cueto, Carmen María; Santana Garrido, Álvaro; Santana Garrido, Álvaro; Ministerio de Ciencia, Innovación y Universidades (MICIU). España; Junta de Andalucía; CTS584: FisioPatología CardiovascularReports related to the study published under the title "Unveiling protective mechanisms of wild olive (wild olive tree) oil in retinal pigment epithelial cells with hypertensive phenotype". This study was funded thanks to the project of the state plan PID2019-109002RB-I00 and the Junta de Andalucía ProyExcel_00516. In both projects, the beneficial properties of wild olive oil at the retinal level are described. Specifically, these data refer to the antioxidant properties of extracellular vesicles obtained from the plasma of animals treated with diets enriched in wild olive oil and their effect on retinal pigment epithelium cells subjected to a hypertensive phenotype. Dataset generated were collected between 2021 and 2024, part of which is the result of research stays abroad in collaboration with the Karolinska Institutet.Conjunto de Datos Dataset from Ophthalmic wild olive (ACEBUCHE) oil nanoemulsions exert oculoprotective effects against oxidative stress induced by arterial hypertension. Int J Pharm. 2024, vol. 649, p. 123602.(2024) Santana Garrido, Álvaro; Durán Lobato, María Matilde; Mate Barrero, Alfonso; Martín Banderas, Lucía; Vázquez Cueto, Carmen María; Farmacia y Tecnología Farmacéutica; Fisiología; Vázquez Cueto, Carmen María; Martín Banderas, Lucía; Santana Garrido, Álvaro; Durán Lobato, María Matilde; Santana Garrido, Álvaro; Durán Lobato, María Matilde; Ministerio de Ciencia, Innovación y Universidades (MICINN). España; Junta de Andalucía; Investigación y Desarrollo Tecnológico en Nanomedicina. CTS480; Fisiopatología Cardiovascular. CTS 5884Dataset of the publication ‘Ophthalmic wild olive (acebuche) oil nanoemulsions exert oculoprotective effects against oxidative stress induced by arterial hypertension'. The work was primarily funded by the state project PID2019-109002RB-I00. The data present the development of a formulation based on acebuchina (ACE) oil nanoemulsions and its beneficial properties on the cornea and retina of animals with arterial hypertension induced by L-NAME. The data generated were collected between 2021 and 2023.