Browsing by Author "Venero Recio, José Luis"
Now showing items 1-20 of 59
-
PhD Thesis
A dual tool. The role of the ripoptosome in phagocytic cell activation and differentiation
(2015-10-19)El término ripoptosoma hace referencia a la plataforma molecular que contiene, entre otras, dos proteínas implicadas en ...
-
Article
APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases
(Springer Nature, 2022)ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human polymorphisms, apoE2, apoE3, and ...
-
Final Degree Project
Apoe y enfermedad de Alzheimer
(2021)La Enfermedad de Alzheimer (EA) es una enfermedad neurodegenerativa que afecta a un creciente número de personas en todo ...
-
Article
Apoptosis-inducing factor mediates dopaminergic cell death in response to LPS-induced inflammatory stimulus: Evidence in Parkinson's disease patients
(Elsevier, 2011-01)We show that intranigral lipopolysaccharide (LPS) injection, which provokes specific degeneration of DA neurons, induced ...
-
Article
ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain
(Nature Research, 2023)Molecular diversity of microglia, the resident immune cells in the CNS, is reported. Whether microglial subsets characterized ...
-
Article
Arginine deprivation alters microglial polarity and synergizes with radiation to eradicate non-arginine-auxotrophic glioblastoma tumors
(American Society for Clinical Investigation, 2022)New approaches for the management of glioblastoma (GBM) are an urgent and unmet clinical need. Here, we illustrate that the ...
-
Final Degree Project
Bases moleculares de los inflamasomas: implicaciones patológicas
(2016)Esta revisión bibliográfica llevada a cabo, nos acerca hacia varios conceptos relativos a diferentes mecanismos que se ...
- PhD Thesis
-
PhD Thesis
Caracterización del modelo condicional neuronal de caspasa 3 en condiciones fisiológicas y patológicas
(2022-12-02)La caspasa 3 (casp 3) es una proteasa ampliamente conocida por su papel clave como mediadora en la apoptosis neuronal. ...
-
Article
Caspase-8 inhibition represses initial human monocyte activation in septic shock model
(Impact Journals, 2016)In septic patients, the onset of septic shock occurs due to the over-activation of monocytes. We tested the therapeutic ...
-
Article
Chronic stress enhances microglia activation and exacerbates death of nigral dopaminergic neurons under conditions of inflammation
(BioMed Central, 2014)Background: Parkinson’s disease is an irreversible neurodegenerative disease linked to progressive movement disorders and ...
-
Article
Deletion of caspase-8 in mouse myeloid cells blocks microglia pro-inflammatory activation and confers protection in MPTP neurodegeneration model
(Impact Journals, LLC, 2015)Increasing evidence involves sustained pro-inflammatory microglia activation in the pathogenesis of different neurodegenerative ...
-
Article
Divergent Effects of Metformin on an Inflammatory Model of Parkinson’s Disease
(Frontiers Media, 2018)The oral antidiabetic drug metformin is known to exhibit anti-inflammatory properties through activation of AMP kinase, ...
-
Article
Effective Knockdown of Gene Expression in Primary Microglia With siRNA and Magnetic Nanoparticles Without Cell Death or Inflammation
(Frontiers Media, 2018)Microglia, the resident immune cells of the brain, have multiple functions in physiological and pathological conditions, ...
- PhD Thesis
-
Article
Fatal levofloxacin failure in treatment of a bacteremic patient infected with Streptococcus pneumoniae with a preexisting parC mutation
(American Society for Microbiology, 2008)The fatal outcome of levofloxacin treatment in a patient with bacteremic pneumonia caused by Streptococcus pneumoniae with ...
-
Article
Gal3 Plays a Deleterious Role in a Mouse Model of Endotoxemia
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)Lipopolysaccharide (LPS)-induced endotoxemia induces an acute systemic inflammatory response that mimics some important ...
-
Article
Galectin-3 Deletion Reduces LPS and Acute Colitis-Induced Pro-Inflammatory Microglial Activation in the Ventral Mesencephalon
(Frontiers Media, 2021)Parkinson’s disease is a highly prevalent neurological disorder for which there is currently no cure. Therefore, the ...
-
Article
Galectin-3 is elevated in CSF and is associated with A beta deposits and tau aggregates in brain tissue in Alzheimer's disease
(Springer, 2022)Galectin-3 (Gal-3) is a beta-galactosidase binding protein involved in microglial activation in the central nervous ...
-
Article
Galectin-3 released in response to traumatic brain injury acts as an alarmin orchestrating brain immune response and promoting neurodegeneration
(Nature, 2017)Traumatic brain injury (TBI) is currently a major cause of morbidity and poor quality of life in Western society, with an ...