Browsing by Author "Tumini, Emanuela"
Now showing items 1-6 of 6
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Article
Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability
(Elsevier, 2019)Although correlations between RNA polymerase II (RNAPII) transcription stress, R-loops, and genome instability have been ...
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Article
Human THO–Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability
(Wiley-Blackwell, 2017)R-loops, formed by co-transcriptional DNA–RNA hybrids and a displaced DNA single strand (ssDNA), fulfill certain positive ...
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Article
Roles of human POLD1 and POLD3 in genome stability
(Nature, 2016)DNA replication is essential for cellular proliferation. If improperly controlled it can constitute a major source of ...
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Article
The antitumor drugs trabectedin and lurbinectedin induce transcription-dependent replication stress and genome instability
(American Association for Cancer Research, 2019)R-loops are a major source of replication stress, DNA damage, and genome instability, which are major hallmarks of cancer ...
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Article
The Fanconi Anemia Pathway Protects Genome Integrity from R-loops
(Public Library of Science, 2015)Co-transcriptional RNA-DNA hybrids (R loops) cause genome instability. To prevent harmful R loop accumulation, cells have ...
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Chapter of Book
The Sister-Chromatid Exchange Assay in Human Cells
(Humana, 2020)The semiconservative nature of DNA replication allows the differential labeling of sister chromatids that isthe fundamental ...