Browsing by Author "Smani Hajami, Tarik"
Now showing items 1-20 of 43
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Article
Adenylyl Cyclase Type 8 Overexpression Impairs Phosphorylation-Dependent Orai1 Inactivation and Promotes Migration in MDA-MB-231 Breast Cancer Cells
(2019-10-23)Orai1 plays a major role in store-operated Ca 2+ entry (SOCE) in triple-negative breast cancer (TNBC) cells. This channel ...
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PhD Thesis
Caracterización del papel de las poblaciones inflamatorias en el infarto revascularizado y sus implicaciones en el remodelado adverso
(2023-07-13)La revascularización temprana después del infarto permite reestablecer el flujo sanguíneo a la zona infartada del corazón ...
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Article
Cardiac protection induced by urocortin-2 enables the regulation of apoptosis and fibrosis after ischemia and reperfusion involving miR-29a modulation
(CELL PRESS (Elsevier), 2022)Urocortin-2 (Ucn-2) has demonstrated cardioprotective ac tions against myocardial ischemia-reperfusion (I/R) injuries. Herein, ...
- PhD Thesis
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Article
Editorial: A Compendium of Recent Research on Stem Cell-Based Therapy for Covid-19
(Frontiers Media, 2021-12-14)We have been dealing with an unprecedented global health crisis for nearly 2 years now. This started after an outbreak of ...
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Article
Editorial: Involvements of TRP channels, oxidative stress and apoptosis in neurodegenerative diseases
(Fontiers Media SA, 2021)The oxygen free radicals generated during metabolism can cause cumulative oxidative damage to nucleic acids, lipids, and ...
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Article
Editorial: Molecular Components of Store-Operated Calcium Entry in Health and Disease
(Frontiers Media, 2021-10-05)Store-Operated Calcium Entry (SOCE) is a ubiquitous Ca2+ influx mechanism first described in 1986 (Putney, 1986). This ...
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Article
EFHB is a Novel Cytosolic Ca2+ Sensor That Modulates STIM1-SARAF Interaction
(S. Karger AG, 2018-11-28)Background/aims: STIM1 and Orai1 are the key components of store-operated Ca2+ entry (SOCE). Among the proteins involved ...
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PhD Thesis
Estudio molecular de la cardioprotección inducida por Urocortina frente al síndrome de isquemia/repercusión.
(2016-06-08)Las enfermedades cardiovasculares siguen siendo la principal causa de morbimortalidad en los países desarrollados (Figura ...
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PhD Thesis
Evaluación de la imagen multimodal para la impresión 3D en cardiopatías congénitas: docencia, aplicaciones clínicas y perspectivas futuras
(2022-12-15)Las cardiopatías congénitas son las malformaciones presentes al nacimiento más frecuentes, y tienen un impacto muy ...
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Article
Furin prodomain ppfurin enhances ca2+ entry through orai and trpc6 channels’ activation in breast cancer cells
(MDPI, 2021-04-01)Furin, a proprotein convertase that belongs to a family of Ca2+-dependent serine peptidases, is involved in the maturation ...
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PhD Thesis
Homeostasis del calcio en miocitos del árbol arterial pulmonar
(2000-07-24)En el presente trabajo se ha estudiado la homeostasis de la (Ca2+) i en miocitos aislados de la arteria pulmonar y el ...
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PhD Thesis
Implicación de la entrada de calcio regulada por los reservorios en la vasoconstricción y proliferación inducida por urotensina-ii en aorta
(2012-06-26)En los últimos años, la terminación de la primera parte del Proyecto Genoma Humano ha traído consigo la identificación de ...
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Article
Innate Immune Receptors, Key Actors in Cardiovascular Diseases
(Elsevier on behalf of the American College of Cardiology Foundation, 2020)Cardiovascular diseases (CVDs) are the leading cause of death in the industrialized world. Most CVDs are associated with ...
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Article
Melatonin downregulates TRPC6, impairing store-operated calcium entry in triple negative breast cancer cells
(Amer Soc Biochemistry Molecular Biology Inc, 2021)Melatonin has been reported to induce effective reduction in growth and development in a variety of tumors, including ...
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Article
miR-125a, miR-139 and miR-324 contribute to Urocortin protection against myocardial ischemiareperfusion injury
(Nature Research, 2017)Urocortin 1 and 2 (Ucn-1 and Ucn-2) have established protective actions against myocardial ischemiareperfusion (I/R) ...
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Article
miR-30b-5p Downregulation as a predictive biomarker of coronary in-stent restenosis
(2021-03-30)In-stent restenosis (ISR) is one of the main limitations of percutaneous coronary intervention (PCI) therapy with drug-eluting ...
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Article
miR-7 Modulates hESC Differentiation into Insulin-Producing Beta-like Cells and Contributes to Cell Maturation
(The American Society of Gene and Cell Therapy, 2018-09-07)Human pluripotent stem cells retain the extraordinary capacity to differentiate into pancreatic beta cells. For this ...
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Article
Orai1 and TRPC1 Proteins Co-localize with CaV1.2 Channels to Form a Signal Complex in Vascular Smooth Muscle Cells
(American Society for Biochemistry and Molecular Biology, 2016)Voltage-dependent CaV1.2 L-type Ca2 channels (LTCC) are the main route for calcium entry in vascular smooth muscle ...
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Article
Orai1α, but not Orai1β, co-localizes with TRPC1 and is required for its plasma membrane location and activation in HeLa cells
(Springer, 2022)The identification of two variants of the canonical pore-forming subunit of the Ca2+ release-activated Ca2+ (CRAC) channel ...