Now showing items 1-7 of 7

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      CSP -deficiency causes massive and rapid photoreceptor degeneration  [Article]

      Schmitz, Frank; Tabares Domínguez, Lucía; Khimich, Darina; Strenzke, Nicola; Villa Polo, Pedro de la; Castellano Muñoz, Manuel; Bulankina, Anna; Moser, Tobias; Fernández-Chacón, Rafael; Südhof, Thomas C. (2006)
      Cysteine string protein (CSP) _ is an abundant synaptic vesicle protein that contains a DNA-J domain characteristic of Hsp40-type cochaperones. Previous studies showed that deletion of CSP_ in mice leads to massive lethal ...
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      CSPα-deficiency causes massive and rapid photoreceptor degeneration  [Article]

      Schmitz, Frank; Tabares Domínguez, Lucía; Khimich, Darina; Strenzke, Nicola; Villa Polo, Pedro de la; Castellano Muñoz, Manuel; Bulankina, Anna; Moser, Tobias; Fernández-Chacón, Rafael; Südhof, Thomas C. (The National Academy of Sciences of the USA, 2006)
      Cysteine string protein (CSP) α is an abundant synaptic vesicle protein that contains a DNA-J domain characteristic of Hsp40-type cochaperones. Previous studies showed that deletion of CSPα in mice leads to massive lethal ...
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      Deletion of CASK in mice is lethal and impairs synaptic function  [Article]

      Atasoy, Deniz; Schoch, Susanne; Ho, Angela; Nadasy, Krisztina A.; Liu, Xinran; Zhang, Weiqi; Mukherjee, Konark; Nosyreva, Elena D.; Fernández-Chacón, Rafael; Missler, Markus; Kavalali, Ege T.; Südhof, Thomas C. (2007)
      CASK is an evolutionarily conserved multidomain protein composed of an N-terminal Ca2_/calmodulin-kinase domain, central PDZ and SH3 domains, and a C-terminal guanylate kinase domain. Many potential activities for CASK ...
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      Examining synaptotagmin 1 function in dense core vesicle exocytosis under direct control of Ca2  [Article]

      Sorensen, Jakob B.; Fernández-Chacón, Rafael; Südhof, Thomas C.; Neher, Erwin (2003)
      We tested the long-standing hypothesis that synaptotagmin 1 is the Ca2 +_ sensor for fast neurosecretion by analyzing the intracellular Ca 2+ dependence of large dense-core vesicle exocytosis in a mouse strain carrying a ...
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      Novel SCAMPs Lacking NPF Repeats: Ubiquitous and Synaptic Vesicle-Specific Forms Implicate SCAMPs in Multiple Membrane- Trafficking Functions  [Article]

      Fernández-Chacón, Rafael; Südhof, Thomas C. (2000)
      In vertebrates, secretory carrier membrane proteins (SCAMPs) 1–3 constitute a family of putative membrane-trafficking proteins composed of cytoplasmic N-terminal sequences with NPF repeats, four central transmembrane regions ...
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      Rab3D Is Not Required for Exocrine Exocytosis but for Maintenance of Normally Sized Secretory Granules  [Article]

      Riedel, Dietmar; Antonin, Wolfram; Fernández-Chacón, Rafael; Álvarez de Toledo Naranjo, Guillermo; Jo, Tobias; Geppert, Martin; Valentijn, Jack A.; Valentijn, Karin; Jamieson, James D.; Südhof, Thomas C.; Jahn, Reinhard (2002)
      Rab3D, a member of the Rab3 subfamily of the Rab/ypt GTPases, is expressed on zymogen granules in the pancreas as well as on secretory vesicles in mast cells and in the parotid gland. To shed light on the function of Rab3D, ...
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      Structure/Function Analysis of Ca2 + Binding to the C2A Domain of Synaptotagmin 1  [Article]

      Fernández-Chacón, Rafael; Shin, Ok-Ho; Königstorfer, Andreas; Matos, Maria F.; Meyer, Alexander C.; García, Jesús; Gerber, Stefan H.; Rizo, Josep; Südhof, Thomas C.; Rosenmund, Christian (2002)
      Synaptotagmin 1, a Ca2+ sensor for fast synaptic vesicle exocytosis, contains two C2 domains that form Ca2+ -dependent complexes with phospholipids. To examine the functional importance of Ca2+ binding to the C2A domain ...