Browsing by Author "Sánchez Varo, Raquel María"
Now showing items 1-17 of 17
-
Article
Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus
(Springer, 2012)Dystrophic neurites associated with amyloid plaques precede neuronal death and manifest early in Alzheimer’s disease ...
-
Article
Age-dependent accumulation of soluble amyloid β (Aβ) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-α (sAPPα) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK- 3β pathway in Alzheimer mouse model
(American Society for Biochemistry and Molecular Biology Inc., 2011)Neurotrophins, activating the PI3K/Akt signaling pathway, control neuronal survival and plasticity. Alterations in NGF, ...
-
Article
Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus
(2012)Background: Axonal pathology might constitute one of the earliest manifestations of Alzheimer disease. Axonal dystrophies ...
-
Article
Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer's mice and patients
(Wiley Open Access, 2019)Neuronal loss is the best neuropathological substrate that correlates with cortical atrophy and dementia in Alzheimer’s ...
-
Article
Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology
(Frontiers Media Research Foundation, 2018-11-14)Microglial cells are crucial players in the pathological process of neurodegenerative diseases, such as Alzheimer’s disease ...
-
Article
Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer’s disease
(Nature Research (part of Springer Nature), 2017)Alzheimer’s disease is a major neurodegenerative disorder that leads to severe cognitive deficits in the elderly population. ...
- PhD Thesis
-
Article
Galectin‑3, a novel endogenous TREM2 ligand, detrimentally regulates infammatory response in Alzheimer’s disease
(Springer, 2019)Alzheimer’s disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of ...
-
Article
Human Pluripotent Stem Cell-Derived Neural Cellsas a Relevant Platform for Drug Screening inAlzheimer’s Disease
(MDPI, 2020)Extracellular amyloid-beta deposition and intraneuronal Tau-laden neurofibrillary tanglesare prime features of Alzheimer’s ...
-
Article
In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer’s disease pathology
(BioMed Central, 2013)Background: Alzheimer’s disease (AD) is characterized by the abnormal accumulation of extracellular beta-amyloid (Abeta) ...
-
Article
Inflammatory response in the hippocampus of PS1M146L/APP 751SL mouse model of Alzheimer's disease: Age-dependent switch in the microglial phenotype from alternative to classic
(Society for Neuroscience, 2008)Although the microglial activation is concomitant to the Alzheimer's disease, its precise role (neuroprotection vs ...
-
Presentation
Litio como terapia neuroprotectora en el modelo appsl/ps1m146l de la enfermedad de Alzheimer
(2013)El litio se utiliza desde hace varias décadas en el tratamiento de trastornos bipolares y la depresión, y recientemente se debate su uso potencial en patologías neurodegenerativas como la enfermedad de Alzheimer (AD).
-
Article
Microglia in Alzheimer’s Disease: Activated, Dysfunctional or Degenerative
(Frontiers Media, 2018)Microglial activation has been considered a crucial player in the pathological process of multiple human neurodegenerative ...
-
Article
Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease
(Wiley, 2018)Reactive astrogliosis, a complex process characterized by cell hypertrophy and upregulation ofcomponents of intermediate ...
-
Article
Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis
(Frontiers Media, 2021)Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by initial memory impairments that ...
-
Article
Soluble phospho‑tau from Alzheimer’s disease hippocampus drives microglial degeneration
(Springer (part of Springer Nature): Springer Open Choice Hybrid Journals, 2016)The role of microglial cells in the development and progression of Alzheimer’s disease (AD) has not been elucidated. Here, ...
-
Article
Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)Alzheimer’s disease (AD) constitutes the most prominent form of dementia among elderly individuals worldwide. Disease ...