Now showing items 1-7 of 7

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      Age-dependent accumulation of soluble amyloid β (Aβ) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-α (sAPPα) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK- 3β pathway in Alzheimer mouse model  [Article]

      Jiménez, Sebastián; Torres, Manuel; Vizuete Chacón, María Luisa; Sánchez Varo, Raquel María; Sánchez Mejías, Elisabeth; Trujillo Estrada, Laura Isabel; Carmona Cuenca, Irene; Caballero, Cristina M.; Ruano Caballero, Diego; Gutiérrez, Antonia (American Society for Biochemistry and Molecular Biology Inc., 2011)
      Neurotrophins, activating the PI3K/Akt signaling pathway, control neuronal survival and plasticity. Alterations in NGF, BDNF, IGF-1, or insulin signaling are implicated in the pathogenesis of Alzheimer disease. We have ...
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      Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus  [Article]

      Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier; Dávila Cansino, José Carlos; Vizuete Chacón, María Luisa; Carmona Cuenca, Irene; Jiménez Muñoz, Sebastián; Trujillo Estrada, Laura Isabel; Sánchez Varo, Raquel María; Torres Canalejo, Manuel; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria (2012)
      Background: Axonal pathology might constitute one of the earliest manifestations of Alzheimer disease. Axonal dystrophies were observed in Alzheimer’s patients and transgenic models at early ages. These axonal dystrophies ...
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      Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer’s disease  [Article]

      Baglietto-Vargas, David; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Jiménez Muñoz, Sebastián; Trujillo Estrada, Laura; Gómez Arboledas, Ángela; Sánchez Mico, María; Sánchez Varo, Raquel; Vizuete Chacón, María Luisa; Dávila, José Carlos; García Verdugo, José Manuel; Vitorica Ferrández, Francisco Javier; Gutiérrez, Antonia (Nature Research (part of Springer Nature), 2017)
      Alzheimer’s disease is a major neurodegenerative disorder that leads to severe cognitive deficits in the elderly population. Over the past two decades, multiple studies have focused on elucidating the causative factors ...
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      In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer’s disease pathology  [Article]

      Trujillo Estrada, Laura Isabel; Jiménez, Sebastián; Castro, Vanessa de; Torres, Manuel; Baglietto-Vargas, David; Moreno González, Inés; Navarro Garrido, Victoria; Sánchez Varo, Raquel María; Sánchez Mejías, Elisabeth; Dávila, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (BioMed Central, 2013)
      Background: Alzheimer’s disease (AD) is characterized by the abnormal accumulation of extracellular beta-amyloid (Abeta) plaques, intracellular hyperphosphorylated tau, progressive synaptic alterations, axonal dystrophies, ...
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      Litio como terapia neuroprotectora en el modelo appsl/ps1m146l de la enfermedad de Alzheimer  [Presentation]

      Trujillo Estrada, Laura Isabel; De Castro, Vanesa; Jiménez Muñoz, Sebastián; Sánchez Varo, Raquel; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Vizuete Chacón, María Luisa; Davila, JC; Vitorica Ferrández, Francisco Javier; Gutiérrez, A. (2013)
      El litio se utiliza desde hace varias décadas en el tratamiento de trastornos bipolares y la depresión, y recientemente se debate su uso potencial en patologías neurodegenerativas como la enfermedad de Alzheimer (AD).
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      Microglia in Alzheimer’s Disease: Activated, Dysfunctional or Degenerative  [Article]

      Navarro Garrido, Victoria; Sánchez Mejías, Elisabeth; Jiménez Muñoz, Sebastián; Muñoz Castro, Clara; Sánchez Varo, Raquel María; Dávila, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (Frontiers Media, 2018)
      Microglial activation has been considered a crucial player in the pathological process of multiple human neurodegenerative diseases. In some of these pathologies, such as Amyotrophic Lateral Sclerosis or Multiple Sclerosis, ...
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      Soluble phospho‑tau from Alzheimer’s disease hippocampus drives microglial degeneration  [Article]

      Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Jiménez, Sebastián; Sánchez Mico, María; Sánchez Varo, Raquel; Núñez Díaz, Cristina; Trujillo Estrada, Laura; Dávila, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (Springer (part of Springer Nature): Springer Open Choice Hybrid Journals, 2016)
      The role of microglial cells in the development and progression of Alzheimer’s disease (AD) has not been elucidated. Here, we demonstrated the existence of a weak microglial response in human AD hippocampus which is in ...