Now showing items 1-16 of 16

    • Icon

      Análisis Funcional de la Fosforilación de Securina  [PhD Thesis]

      Mora Santos, María del Mar (2011)
      El objetivo de esta Tesis se engloba dentro de un estudio más amplio sobre el análisis funcional de la fosforilación de Securina, y para ello nos hemos planteado abordar dos objetivos concretos: ... 39;serif'; font-size: ...
    • Icon

      Both p62/SQSTM1-HDAC6-dependent autophagy and the aggresome pathway mediate CDK1 degradation in human breast cancer  [Article]

      Galindo Moreno, María; Giráldez Macías, Servando; Sáez, Carmen; Japón Rodríguez, Miguel Ángel; Tortolero García, María Dolores; Romero Portillo, Francisco (Nature Publishing Group, 2017)
      Cyclin-dependent kinase 1 (CDK1) is the central mammalian regulator of cell proliferation and a promising therapeutic target for breast cancer. In fact, CDK1 inhibition downregulates survival and induces apoptosis. Due to ...
    • Icon

      Breast cancer cell line MCF7 escapes from G1/S arrest induced by proteasome inhibition through a GSK-3β dependent mechanism  [Article]

      Gavilán Dorronzoro, Elena; Giraldez Macias, Servando; Sánchez Aguayo, Inmaculada; Romero Portillo, Francisco; Ruano Caballero, Diego; Daza Navarro, María Paula (Nature, 2015)
      Targeting the ubiquitin proteasome pathway has emerged as a rational approach in the treatment of human cancers. Autophagy has been described as a cytoprotective mechanism to increase tumor cell survival under stress ...
    • Icon

      Estudio genético de la nodulación de "Rhizobium fredii"  [PhD Thesis]

      Romero Portillo, Francisco (1993)
      En esta tesis se han estudiado diversos aspectos de la nodulación de las estirpes de Rhizobium fredii. Esta especie está constituida por diferentes estirpes que se caracterizan por ser de crecimiento rápido (2 a 4 horas ...
    • Icon

      hSiah2 is a new vav binding protein which inhibits Vav-mediated signaling pathways  [Article]

      Germani, Antonia; Romero Portillo, Francisco; Houlard, Martin; Camonis, Jacques H.; Gisselbrecht, Sylvie; Fischer, Siegmund; Varin-Blank, Nadine (1999)
      The hematopoietic proto-oncogene vav has been characterized as a Rac1- GDP/GTP exchanger protein which regulates cytoskeletal reorganization as well as signaling pathways leading to the activation of stress-activated protein ...
    • Icon

      Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase  [Article]

      Tortolero García, María Dolores; Romero Portillo, Francisco; Bernal Rodríguez, Juan Antonio; Ramos Morales, Francisco; Domínguez, África (2001)
    • Icon

      Importancia de la desregulación de la degradación de proteínas del ciclo celular en el cáncer  [PhD Thesis]

      Galindo Moreno, María (2019-06-14)
      La viabilidad de las células depende del buen funcionamiento de un conjunto de mecanismos moleculares que controlan los procesos biológicos. La ubicuitilación de las proteínas permite degradar rápidamente los componentes ...
    • Icon

      Obatoclax and Paclitaxel Synergistically Induce Apoptosis and Overcome Paclitaxel Resistance in Urothelial Cancer Cells  [Article]

      Jiménez Guerrero, Rocío; Gasca Bellido, Jessica María; Flores, M. Luz; Pérez Valderrama, Begoña; Medina, Rafael; Tortolero García, María Dolores; Romero Portillo, Francisco; Japón Rodríguez, Miguel Ángel (MDPI, 2018)
      Paclitaxel is a treatment option for advanced or metastatic bladder cancer after the failure of first-line cisplatin and gemcitabine, although resistance limits its clinical benefits. Mcl-1 is an anti-apoptotic protein ...
    • Icon

      p53 and FBXW7: Sometimes Two Guardians Are Worse than One  [Article]

      Galindo Moreno, María; Giráldez Macías, Servando; Limón Mortés, María Cristina; Belmonte Fernández, Alejandro; Sáez, Carmen; Japón, Miguel Ángel; Tortolero García, María Dolores; Romero Portillo, Francisco (MDPI, 2020)
      Too much of a good thing can become a bad thing. An example is FBXW7, a well-known tumor suppressor that may also contribute to tumorigenesis. Here, we reflect on the results of three laboratories describing the role of ...
    • Icon

      Protein phosphatase 2A stabilizes human securin, whose phosphorylated forms are degraded via the SCF ubiquitin ligase  [Article]

      Gil Bernabé, Ana María; Romero Portillo, Francisco; Limón Mortés, María Cristina; Tortolero García, María Dolores (2006)
      Sister chromatid segregation is triggered at the metaphase-to-anaphase transition by the activation of the protease separase. For most of the cell cycle, separase activity is kept in check by its association with the ...
    • Icon

      Regulación de la estabilidad de la oncoproteína PTTG1/hSecurina  [PhD Thesis]

      Limón Mortés, María Cristina (2007)
      El objetico de esta Tesis es el estudio de la relación de la estabilidad de la oncoproteína PTTG1/Sec. Para ello nos proponemos abordar dos objetivos concretos: 1. La securina humana, PTTG1/Sec, además de su función como ...
    • Icon

      Securin Is a Target of the UV Response Pathway in Mammalian Cells  [Article]

      Romero Portillo, Francisco; Gil-Bernabé, Ana M.; Sáez, Carmen; Pintor Toro, José Antonio; Tortolero García, María Dolores (2004)
      All eukaryotic cells possess elaborate mechanisms to protect genome integrity and ensure survival after DNA damage, ceasing proliferation and granting time for DNA repair. Securin is an inhibitory protein that is bound to ...
    • Icon

      Tubulin Folding Cofactor TBCB is a Target of the Salmonella Effector Protein SseK1  [Article]

      Araujo Garrido, Juan Luis; Baisón Olmo, Fernando; Bernal Bayard, Joaquín; Romero Portillo, Francisco; Ramos Morales, Francisco (MDPI, 2020)
      Salmonella enterica serovar Typhimurium is a human and animal pathogen that uses type III secretion system effectors to manipulate the host cell and fulfill infection. SseK1 is a Salmonella effector with glycosyltransferase ...
    • Icon

      Uso periodístico de las redes sociales : ventajas, obstáculos y riesgos  [Presentation]

      Romero Portillo, Francisco; Vidal Vega, Javier (Edufora, 2012)
      Desde 2003, las redes sociales se han convertido en una herramienta cotidiana para millones de personas en todo el mundo. Páginas como Facebook o Twitter, que permiten a los ciudadanos compartir mensajes e imágenes, han ...
    • Icon

      UV-induced degradation of securin is mediated by SKP1-CUL1-βTrCP E3 ubiquitin ligase  [Article]

      Limón Mortés, María Cristina; Mora Santos, María del Mar; Espina Zambrano, Águeda Gema; Pintor Toro, José Antonio; López Román, Antonio; Tortolero García, María Dolores; Romero Portillo, Francisco (Company of Biologists, 2008)
      Securin is a chaperone protein with bifunctional properties. It binds to separase to inhibit premature sister chromatid separation until the onset of anaphase, and it also takes part in cell-cycle arrest after UV irradiation. ...
    • Icon

      βTrCP controls the lysosome-mediated degradation of CDK1, whose accumulation correlates with tumor malignancy  [Article]

      Herrero Ruiz, Joaquín; Mora Santos, María del Mar; Giraldez Macias, Servando; Sáez Torres, Carmen; Romero Portillo, Francisco; Japón Rodríguez, Miguel Ángel (Impact Journals, 2014)
      n mammals, cell cycle progression is controlled by cyclin-dependent kinases, among which CDK1 plays important roles in the regulation of the G2/M transition, G1 progression and G1/S transition. CDK1 is highly regulated by ...