Browsing by Author "Rojo, Javier"
Now showing items 1-9 of 9
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Article
Cyclooctyne [60]fullerene hexakis adducts: a globular scaffold for copper-free click chemistry
(Royal Society of Chemistry, 2016)The synthesis of a new highly symmetric hexakis adduct of C60 appended with 12 cyclooctyne moieties has been carried out. ...
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Article
Detection and Quantitative Analysis of Two Independent Binding Modes of a Small Ligand Responsible for DC-SIGN Clustering
(Royal Society of Chemistry, 2015)DC-SIGN (dendritic cell-specific ICAM-3 grabbing non-integrin) is a C-type lectin receptor (CLR) present, mainly in dendritic ...
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Article
Docking, synthesis, and NMR studies of mannosyl trisaccharide ligands for DC-SIGN lectin
(Royal Society of Chemistry (Great Britain), 2008)DC-SIGN, a lectin, which presents at the surface of immature dendritic cells, constitutes nowadays a promising target for ...
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Article
Glycosylated nanostructures in sublingual immunotherapy induce long-lasting tolerance in LTP allergy mouse model
(Nature, 2019-02-11)An effective specific immunotherapy should contain elements to generate specific recognition (T-cell peptides) and to ...
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Article
LPS promotes Th2 dependent sensitisation leading to anaphylaxis in a Pru p 3 mouse model
(Nature Publishing Group, 2017-01-13)Pru p 3 is the major peach allergen in the Mediterranean area. It frequently elicits severe reactions, limiting its study ...
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Article
NMR studies on carbohydrate interactions with DC-SIGN towards a quantitative STD analysis
(De Gruyter, 2013)The recent introduction of saturation transfer difference (STD) NMR has increased the tools for the study of protein–carbohydrate ...
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Synthesis of giant globular multivalent glycofullerenes as potent inhibitors in a model of Ebola virus infection
(Nature Publishing Group, 2016)The use of multivalent carbohydrate compounds to block cell-surface lectin receptors is a promising strategy to inhibit ...
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Article
Unique DC-SIGN clustering activity of a small glycomimetic: a lesson for ligand design
(American Chemical Society, 2014)DC-SIGN is a dendritic cell-specific C-type lectin receptor that recognizes highly glycosylated ligands expressed on the ...
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Article
Virus-like glycodendrinanoparticles displaying quasi-equivalent nested polyvalency upon glycoprotein platforms potently block viral infection
(Nature Publishing Group, 2012)Ligand polyvalency is a powerful modulator of protein–receptor interactions. Host–pathogen infection interactions are often ...