Now showing items 1-4 of 4

    • Icon

      Caspase-8 inhibition represses initial human monocyte activation in septic shock model  [Article]

      Oliva Martín, María José; Sánchez Abarca, Luis Ignacio; Rodhe, Johanna; Carrillo Jiménez, Alejandro; Vlachos, Pinelopi; Herrera Carmona, Antonio José; García Quintanilla, Alberto; Caballero Velázquez, Teresa; Venero Recio, José Luis (Impact Journals, 2016)
      In septic patients, the onset of septic shock occurs due to the over-activation of monocytes. We tested the therapeutic potential of directly targeting innate immune cell activation to limit the cytokine storm and downstream ...
    • Icon

      Deletion of caspase-8 in mouse myeloid cells blocks microglia pro-inflammatory activation and confers protection in MPTP neurodegeneration model  [Article]

      Kavanagh, Edel T.; Burguillos García, Miguel Ángel; Carrillo Jiménez, Alejandro; Oliva Martín, María José; Santiago Pavón, Martiniano; Rodhe, Johanna; Joseph, Bertrand; Venero Recio, José Luis (Impact Journals, LLC, 2015)
      Increasing evidence involves sustained pro-inflammatory microglia activation in the pathogenesis of different neurodegenerative diseases, particularly Parkinson's disease (PD). We recently uncovered a completely novel and ...
    • Icon

      Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia  [Article]

      Kavanagh, Edel T.; Rodhe, Johanna; Burguillos García, Miguel Ángel; Venero Recio, José Luis; Joseph, Bertrand (Nature Publishing Group, 2014)
      The activation of microglia, resident immune cells of the central nervous system, and inflammation-mediated neurotoxicity are typical features of neurodegenerative diseases, for example, Alzheimer's and Parkinson's diseases. ...
    • Icon

      Spatio-temporal activation of caspase-8 in myeloid cells upon ischemic stroke  [Article]

      Rodhe, Johanna; Burguillos García, Miguel Ángel; Martínez de Pablos, Rocío; Kavanagh, Edel T.; Persson, Annette; Englund, Elisabet; Venero Recio, José Luis (BioMed Central, 2016)
      Ischemic stroke (caused by thrombosis, embolism or vasoconstriction) lead to the recruitment and activation of immune cells including resident microglia and infiltrating peripheral macrophages, which contribute to an ...