idUS - Browsing by Author "Robina Ramírez, Inmaculada"

Article

Amine-linked diglycosides: synthesis facilitated by the enhanced reactivity of allylic electrophiles, and glycosidase inhibition assays

Moreno Clavijo, Elena; Cumpstey, Ian; Frigell, Jens; Pershagen, Elias; Akhtar, Tashfeen; Alonzi, Dominic S.; Butters, Terry D.; Robina Ramírez, Inmaculada (2011)

PhD Thesis

Aminooligosacaridos. Síntesis de glicosilaminas de disacaridos y de lipooligosacaridos

López Barba, Eugenia (1995-10-02)

La presente tesis se ha dividido en dos partes: -reacciones regioselectivas en aminoazucares.En esta parte se han preparado ...

Article

Azabicyclic vinyl sulfones for residue-specific dual protein labelling

Gil de Montes Rojas, Enrique; Jiménez Moreno, Ester; Oliveira, Bruno L.; Navo, Claudio D.; Robina Ramírez, Inmaculada; Moreno Vargas, Antonio José (Royal Society of Chemistry, 2019)

We have developed [2.2.1]azabicyclic vinyl sulfone reagents that simultaneously enable cysteine-selective protein modification ...

Article

Discovery of a Potent α ‑ Galactosidase Inhibitor by in Situ Analysis of a Library of Pyrrolizidine − (Thio)urea Hybrid Molecules Generated via Click Chemistry

Elías Rodríguez, María del Pilar; Pingitore, Valeria; Carmona Asenjo, Ana Teresa; Moreno Vargas, Antonio José; Ide, Daisuke; Miyawaki, Shota; Kato, Atsushi; Álvarez González, Eleuterio; Robina Ramírez, Inmaculada (American Chemical Society, 2018)

The parallel synthesis of a 26-membered-library of aromatic/aliphatic-(thio)urea-linked pyrrolizidines followed by in ...

Article

Discovery of human hexosaminidase inhibitors by in situ screening of a library of mono- and divalent pyrrolidine iminosugars

Pingitore, Valeria; Martínez Bailén, Macarena; Carmona Asenjo, Ana Teresa; Mészáros, Zuzana; Kulik, Natalia; Slámová, Kristýna; Křen, Vladimír; Bojarová, Pavla; Robina Ramírez, Inmaculada; Moreno Vargas, Antonio José (Elsevier, 2022)

Two libraries of mono- and dimeric pyrrolidine iminosugars were synthesized by CuAAC and (thio)urea-bond-forming reactions ...

PhD Thesis

Diseño y síntesis de derivados mono- y multivalentes de 1,4-iminociclitoles: estudio de sus propiedades como inhibidores de glicosidasas.

Martínez Bailen, Macarena (2019-04-05)

Article

Exploring architectures displaying multimeric presentations of a trihydroxypiperidine iminosugar

Matassini, Camilla; Mirabella, Stefania; Goti, Andrea; Robina Ramírez, Inmaculada; Moreno Vargas, Antonio José; Cardona, Francesca (Beilstein-Institut Zur Forderung der Chemischen Wissenschaften, 2015)

The synthesis of new multivalent architectures based on a trihydroxypiperidine α -fucosidase inhibitor is reported ...

Article

Exploring Multi-Subsite Binding Pockets in Proteins: DEEP-STD NMR Fingerprinting and Molecular Dynamics Unveil a Cryptic Subsite at the GM1 Binding Pocket of Cholera Toxin B

Monaco, Serena; Walpole, Samuel; Doukani, Hassan; Nepravishta, Ridvan; Martínez Bailén, Macarena; Carmona Asenjo, Ana Teresa; Ramos Soriano, Francisco Javier; Robina Ramírez, Inmaculada; Angulo Álvarez, Jesús (Wiley, 2020)

Ligand-based NMRtechniquesto studyprotein–ligandinteractionsare potenttoolsin drugdesign.Satura-tiontransfer difference ...

PhD Thesis

Feniltio y fenilsulfinil glicósidos: síntesis de análogos de factoes Nod y de y de C-sulfocelobiosas

Gómez Bujedo, Silvia (1999)

La presente Tesis Doctoral se encuadra dentro de los proyectos de investigación sobre Isotiocianato, tioamnio- y ...

Article

Gold nanoparticles are suitable cores for building tunable iminosugar multivalency

Matassini, Camilla; Marradi, M.; Cardona, F.; Parmeggiani, C.; Robina Ramírez, Inmaculada; Moreno Vargas, Antonio José; Penadés, S.; Goti, A. (Royal Society of Chemistry: Open Access, 2015)

The first example of iminosugars multimerization based on gold nanoparticle cores was achieved by a straightforward ...

Article

Iminosugar-Phosphines as Organocatalysts in the [3 + 2] Cycloaddition of Allenoates and N-Tosylimines

Elías Rodríguez, María del Pilar; Carmona Asenjo, Ana Teresa; Moreno Vargas, Antonio José; Robina Ramírez, Inmaculada (Multidisciplinary Digital Publishing Institute (MDPI), 2022)

Iminosugar derivatives containing a pyrrolidine-phosphine moiety were prepared from carbohydrates and used as catalysts ...

Article

Inter-Ligand STD NMR: An Efficient 1D NMR Approach to Probe Relative Orientation of Ligands in a Multi-Subsite Protein Binding Pocket

Monaco, Serena; Ramírez Cárdenas, Jonathan; Carmona Asenjo, Ana Teresa; Robina Ramírez, Inmaculada; Angulo Álvarez, Jesús (Multidisciplinary Digital Publishing Institute (MDPI), 2022)

In recent years, Saturation Transfer Difference NMR (STD NMR) has been proven to be a powerful and versatile ligand-based ...

Article

Mechanistic Insight into the Binding of Multivalent Pyrrolidines to α-Mannosidases

Mirabella, Stefania; D'Adamio, Giampiero; Matassini, Camilla; Goti, Andrea; Delgado, Sandra; Gimeno, Ana; Robina Ramírez, Inmaculada; Moreno Vargas, Antonio José; Šesták, Sergej; Jiménez Barbero, Jesús; Cardona, Francesca (Wiley-Blackwell, 2017)

Novel pyrrolidine-based multivalent iminosugars, synthesized by a CuAAC approach, have shown remarkable multivalent effects ...

Article

Monosaccharides and Analogues from Simple Achiral Unsaturated Compounds

Moreno Vargas, Antonio José; Carmona Asenjo, Ana Teresa; Moreno Clavijo, Elena; Robina Ramírez, Inmaculada (Schweizerische Chemische Gesellschaft, 2011)

We present herein a selection of ingenious methods that have been developed to convert inexpensive furan, pyrrole and unsaturated hydrocarbons into enantiomerically enriched monosaccharides and analogues of biological interest.

PhD Thesis

Preparación, aplicaciones y reactividad de nuevos derivados de iminoazúcares. Síntesis de análogos del FK866 con propiedades anticáncer

Elías Rodríguez, María del Pilar (2017-05-23)

En esta Tesis Doctoral se ha desarrollado la síntesis de nuevos (pirrolidín-2-il)-Ctriazoles con configuración L-fuco ...

PhD Thesis

Síntesis estereoselectiva de nuevos furil-aminoácidos y su uso en la preparación de plataformas moleculares y de ligando de biomoléculas

Molina Sanz, Lidia (2009-03-27)

Los polihidroxialquil-heterociclos son intermedios sintéticos muy interesantes para la preparación de productos de interés ...

PhD Thesis

Síntesis y reactividad de sistemas [2.2.1]bicíclicos. Estudio de la bioconjugación de proteínas con azanorbornadienos

Gil de Montes Rojas, Enrique (2020-05-24)

En esta Tesis Doctoral se presentan los resultados más relevantes obtenidos del estudio de reactividad llevado a cabo ...

Article

Stable Pyrrole-Linked Bioconjugates through Tetrazine-Triggered Azanorbornadiene Fragmentation

Gil de Montes, Enrique; Istrate, Alena; Navo, Claudio D.; Jiménez Moreno, Ester; Hoyt, Emily A.; Corzana, Francisco; Robina Ramírez, Inmaculada; Jiménez Osés, Gonzalo; Moreno Vargas, Antonio José; Bernardes, Gonçalo J.L. (Wiley-Blackwell, 2020)

An azanorbornadiene bromovinyl sulfone reagent for cysteine-selective bioconjugation has been developed. Subsequent reaction ...

Article

Stereoselective synthesis of chiral furan amino acid analogues of D- and L-serine from D-sugars

Molina, Lidia; Moreno Vargas, Antonio José; Carmona Asenjo, Ana Teresa; Robina Ramírez, Inmaculada (Georg Thieme Verlag, 2006)

The synthesis of chiral furan amino acid analogues of D - and L -serine is reported. The developed methodology ...

Article

Structural Basis of the Inhibition of GH1 β-glucosidases by Multivalent Pyrrolidine Iminosugars

Martínez Bailén, Macarena; Jiménez Ortega, Elena; Carmona Asenjo, Ana Teresa; Robina Ramírez, Inmaculada; Sanz Aparicio, Julia; Talens Perales, David; Polaina, Julio; Matassini, Camilla; Cardona, Francesca; Moreno Vargas, Antonio José (Elsevier, 2019)

The synthesis of multivalent pyrrolidine iminosugars via CuAAC click reaction between different pyrrolidine-azide derivatives ...

Browsing by Author "Robina Ramírez, Inmaculada"

Amine-linked diglycosides: synthesis facilitated by the enhanced reactivity of allylic electrophiles, and glycosidase inhibition assays ﻿

Aminooligosacaridos. Síntesis de glicosilaminas de disacaridos y de lipooligosacaridos ﻿

Azabicyclic vinyl sulfones for residue-specific dual protein labelling ﻿

Discovery of a Potent α ‑ Galactosidase Inhibitor by in Situ Analysis of a Library of Pyrrolizidine − (Thio)urea Hybrid Molecules Generated via Click Chemistry ﻿

Discovery of human hexosaminidase inhibitors by in situ screening of a library of mono- and divalent pyrrolidine iminosugars ﻿

Diseño y síntesis de derivados mono- y multivalentes de 1,4-iminociclitoles: estudio de sus propiedades como inhibidores de glicosidasas. ﻿

Exploring architectures displaying multimeric presentations of a trihydroxypiperidine iminosugar ﻿

Exploring Multi-Subsite Binding Pockets in Proteins: DEEP-STD NMR Fingerprinting and Molecular Dynamics Unveil a Cryptic Subsite at the GM1 Binding Pocket of Cholera Toxin B ﻿

Feniltio y fenilsulfinil glicósidos: síntesis de análogos de factoes Nod y de y de C-sulfocelobiosas ﻿

Gold nanoparticles are suitable cores for building tunable iminosugar multivalency ﻿

Iminosugar-Phosphines as Organocatalysts in the [3 + 2] Cycloaddition of Allenoates and N-Tosylimines ﻿

Inter-Ligand STD NMR: An Efficient 1D NMR Approach to Probe Relative Orientation of Ligands in a Multi-Subsite Protein Binding Pocket ﻿

Mechanistic Insight into the Binding of Multivalent Pyrrolidines to α-Mannosidases ﻿

Monosaccharides and Analogues from Simple Achiral Unsaturated Compounds ﻿

Preparación, aplicaciones y reactividad de nuevos derivados de iminoazúcares. Síntesis de análogos del FK866 con propiedades anticáncer ﻿

Síntesis estereoselectiva de nuevos furil-aminoácidos y su uso en la preparación de plataformas moleculares y de ligando de biomoléculas ﻿

Síntesis y reactividad de sistemas [2.2.1]bicíclicos. Estudio de la bioconjugación de proteínas con azanorbornadienos ﻿

Stable Pyrrole-Linked Bioconjugates through Tetrazine-Triggered Azanorbornadiene Fragmentation ﻿

Stereoselective synthesis of chiral furan amino acid analogues of D- and L-serine from D-sugars ﻿

Structural Basis of the Inhibition of GH1 β-glucosidases by Multivalent Pyrrolidine Iminosugars ﻿

Amine-linked diglycosides: synthesis facilitated by the enhanced reactivity of allylic electrophiles, and glycosidase inhibition assays

Aminooligosacaridos. Síntesis de glicosilaminas de disacaridos y de lipooligosacaridos

Azabicyclic vinyl sulfones for residue-specific dual protein labelling

Discovery of a Potent α ‑ Galactosidase Inhibitor by in Situ Analysis of a Library of Pyrrolizidine − (Thio)urea Hybrid Molecules Generated via Click Chemistry

Discovery of human hexosaminidase inhibitors by in situ screening of a library of mono- and divalent pyrrolidine iminosugars

Diseño y síntesis de derivados mono- y multivalentes de 1,4-iminociclitoles: estudio de sus propiedades como inhibidores de glicosidasas.

Exploring architectures displaying multimeric presentations of a trihydroxypiperidine iminosugar

Exploring Multi-Subsite Binding Pockets in Proteins: DEEP-STD NMR Fingerprinting and Molecular Dynamics Unveil a Cryptic Subsite at the GM1 Binding Pocket of Cholera Toxin B

Feniltio y fenilsulfinil glicósidos: síntesis de análogos de factoes Nod y de y de C-sulfocelobiosas

Gold nanoparticles are suitable cores for building tunable iminosugar multivalency

Iminosugar-Phosphines as Organocatalysts in the [3 + 2] Cycloaddition of Allenoates and N-Tosylimines

Inter-Ligand STD NMR: An Efficient 1D NMR Approach to Probe Relative Orientation of Ligands in a Multi-Subsite Protein Binding Pocket

Mechanistic Insight into the Binding of Multivalent Pyrrolidines to α-Mannosidases

Monosaccharides and Analogues from Simple Achiral Unsaturated Compounds

Preparación, aplicaciones y reactividad de nuevos derivados de iminoazúcares. Síntesis de análogos del FK866 con propiedades anticáncer

Síntesis estereoselectiva de nuevos furil-aminoácidos y su uso en la preparación de plataformas moleculares y de ligando de biomoléculas

Síntesis y reactividad de sistemas [2.2.1]bicíclicos. Estudio de la bioconjugación de proteínas con azanorbornadienos

Stable Pyrrole-Linked Bioconjugates through Tetrazine-Triggered Azanorbornadiene Fragmentation

Stereoselective synthesis of chiral furan amino acid analogues of D- and L-serine from D-sugars

Structural Basis of the Inhibition of GH1 β-glucosidases by Multivalent Pyrrolidine Iminosugars