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Browsing by Author "Peñate Salas, Xenia"
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Article
A Genome-Wide Screen Identifies Yeast Genes Required for Tolerance to Technical Toxaphene, an Organochlorinated Pesticide Mixture
Gaytán, B. D.; Lerot, J. M.; Chávez de Diego, Sebastián; Peñate Salas, Xenia; Loguinov, A.; Denslow, N.; Vulpe, C. (2013) -
PhD Thesis
Contribución de prefoldina a la expresión génica en células humanas
Payán Bravo, Laura (2019-03-15)La prefoldina es una cochaperona que está presente en todos los organismos eucarióticos. Es conocida principalmente por ...
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Article
CYK4 inhibits Rac1-dependent PAK1 and ARHGEF7 effector pathways during cytokinesis
Nunes Bastos, Ricardo; Peñate Salas, Xenia; Bates, Michelle; Hammond, Dean; Barr, Francis A. (Rockefeller University Press, 2012)In mitosis, animal cells lose their adhesion to the surrounding surfaces and become rounded. During mitotic exit, they ...
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Article
High levels of histones promote whole-genome-duplications and trigger a Swe1WEE1-dependent phosphorylation of Cdc28CDK1
Maya Miles, Douglas; Peñate Salas, Xenia; Sanmartín Olmo, Trinidad; Jourquin, Frederic; Muñoz Centeno, María de la Cruz; Mendoza, Manuel; Simon, Marie-Noelle; Chávez de Diego, Sebastián; Geli, Vincent (eLife Sciences, 2018-03-27)Whole-genome duplications (WGDs) have played a central role in the evolution of genomes and constitute an important source ...
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Article
Human prefoldin modulates co-transcriptional pre-mRNA splicing
Payán Bravo, Laura; Fontalva Ostio, Sara; Peñate Salas, Xenia; Cases, Ildefonso; Guerrero Martínez, José A.; Pareja Sánchez, Yerma; Odriozola Gil, Yosu; Lara, Esther; Jimeno González, Silvia; Suñé Negre, Carlos María; Muñoz Centeno, María de la Cruz; Reyes, José C.; Chávez de Diego, Sebastián (Oxford University Press, 2021)Prefoldin is a heterohexameric complex conserved from archaea to humans that plays a cochaperone role during the ...
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Article
One step back before moving forward: regulation of transcription elongation by arrest and backtracking
Gómez Herreros, Fernando; Miguel Jiménez, María Dolores De; Millán Zambrano, Gonzalo; Peñate Salas, Xenia; Delgado Ramos, Lidia; Muñoz Centeno, María de la Cruz; Chávez de Diego, Sebastián (Wiley-Blackwell, 2012)RNA polymerase II backtracking is a well-known phenomenon, but its involvement in gene regulation is yet to be addressed. ...
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Article
Overexpression of canonical prefoldin associates with the risk of mortality and metastasis in non-small cell lung cancer
Peñate Salas, Xenia; Praena Fernández, Juan Manuel; Romero Pareja, Pedro; Enguix Riego, María del Valle; Payán Bravo, Laura; Vieites Pérez-Quintela, Begoña; Chávez de Diego, Sebastián; López Guerra, José Luis (2020-04-24)Canonical prefoldin is a protein cochaperone composed of six di erent subunits (PFDN1 to 6). PFDN1 overexpression promotes ...
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Article
Subtracting the sequence bias from partially digested MNase-seq data reveals a general contribution of TFIIS to nucleosome positioning
Gutiérrez Pozo, Gabriel; Millán Zambrano, Gonzalo; Medina, Daniel A.; Jordán Pla, Antonio; Pérez Ortín, José E.; Peñate Salas, Xenia; Chávez de Diego, Sebastián (BioMed Central, 2017)TFIIS stimulates RNA cleavage by RNA polymerase II and promotes the resolution of backtracking events. TFIIS acts in the ...
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Article
The Prefoldin Complex Regulates Chromatin Dynamics during Transcription Elongation
Millán Zambrano, Gonzalo; Rodríguez Gil, Alfonso; Peñate Salas, Xenia; Miguel Jiménez, María Dolores De; Morillo Huesca, Macarena; Krogan, Nevan; Chávez de Diego, Sebastián (Public Library of Science, 2013)Transcriptional elongation requires the concerted action of several factors that allow RNA polymerase II to advance through ...
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Article
Xrn1 influence on gene transcription results from the combination of general effects on elongating RNA pol II and gene-specific chromatin configuration
Begley, Victoria Sarah; Jordán Pla, Antonio; Peñate Salas, Xenia; Garrido Godino, Ana Isabel; Challal, Drice; Cuevas Bermúdez, Abel; Mitjavila, Adrià; Barucco, Mara; Gutiérrez Pozo, Gabriel; Singh, Abhyudai; Alepuz, Paula M.; Chávez de Diego, Sebastián (Taylor & Francis, 2021)mRNA homoeostasis is favoured by crosstalk between transcription and degradation machineries. Both the Ccr4-Not and the ...