Browsing by Author "Pérez Simón, José Antonio"
Now showing items 1-20 of 77
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Article
A Conditional Mouse Mutant in the Tumor Suppressor SdhD Gene Unveils a Link between p21(WAF1/Cip1) Induction and Mitochondrial Dysfunction
(Public Library Science, 2021-01-20)Mutations in mitochondrial complex II (MCII; succinate dehydrogenase, Sdh) genes cause familiar pheochromocytoma/ paraganglioma ...
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Article
A phase II, prospective, randomized, open-label study of defibrotide added to standard-of-care prophylaxis for the prevention of acute graft-versus-host disease after allogeneic hematopoietic cell transplantation
(Ferrata Storti Foundation, 2023)Acute graft-versus-host disease (aGvHD) is a life-threatening complication typically occurring within 100 days after ...
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All-trans retinoic acid works synergistically with the γ-secretase inhibitor crenigacestat to augment BCMA on multiple myeloma and the efficacy of BCMA-CAR T cells
(Ferrata Storti Foundation, 2023)B-cell maturation antigen (BCMA) is the lead antigen for chimeric antigen receptor (CAR) T-cell therapy in multiple ...
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An Active Isodicentric X Chromosome in a Case of Refractory Anaemia with Ring Sideroblasts Associated with Marked Thrombocytosis
(Hindawi, 2014)Refractory anaemia with ring sideroblasts and marked thrombocytosis (RARS-T) is a provisional entity in the World Health ...
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ASXL1 mutation as a surrogate marker in acute myeloid leukemia with myelodysplasia-related changes and normal karyotype
(Wiley Open Access, 2020)Acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) are poor outcome leukemias. Its diagnosis is based ...
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PhD Thesis
Cambios en los perfiles de expresión génica en condiciones fisiológicas versus patológicas en el sistema hematopoyético
(2014-12-12)El trabajo realizado en esta tesis doctoral consiste en el estudio de los cambios en la expresión génica que sufren las ...
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Article
Cannabinoids induce cell death in leukaemic cells through Parthanatos and PARP-related metabolic disruptions
(Nature Publishing Group, 2024)BACKGROUND: Several studies have described a potential anti-tumour effect of cannabinoids (CNB). CNB receptor 2 (CB2) is ...
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CD4+ and CD8+ T-cell responses in bone marrow to fatty acids in high-fat diets
(Elsevier, 2022)Obesity is associated with disruptions in the adaptive immune system; however, dietary fatty acids in high-fat diets (HFDs) ...
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Cholinergic signals preserve haematopoietic stem cell quiescence during regenerative haematopoiesis
(Nature Publishing Group, 2022)The sympathetic nervous system has been evolutionary selected to respond to stress and activates haematopoietic stem cells ...
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Article
Clinical benefit of glasdegib plus low-dose cytarabine in patients with de novo and secondary acute myeloid leukemia: long-term analysis of a phase II randomized trial
(Springer, 2021)This analysis from the phase II BRIGHT AML 1003 trial reports the long-term efficacy and safety of glasdegib + ...
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Combined treatment of graft versus host disease using donor regulatory T cells and ruxolitinib
(Nature Publishing Group, 2022)Donor derived regulatory T lymphocytes and the JAK1/2 kinase inhibitor ruxolitinib are currently being evaluated as ...
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Comparison of outcomes for HLA-matched sibling and haplo identical donors in Myelodysplastic syndromes: report from the chronic malignancies working party of EBMT
(Springer Nature, 2022)Myelodysplastic syndromes (MDS) are the second common indication for an Allo-HCT. We compared the outcomes of 1414 matched ...
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Comparison of the 2022 and 2017 European LeukemiaNet risk classifications in a real-life cohort of the PETHEMA group
(Springer Nature, 2023)Next-Generation Sequencing is needed for the accurate genetic risk stratification of acute myeloid leukemia according to ...
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Compassionate use of ruxolitinib in acute and chronic graft versus host disease refractory both to corticosteroids and extracorporeal photopheresis
(BioMed Central, 2017)Background: Ruxolitinib is a potent inhibitor of JAK1/2 with proven efcacy in myelofbrosis. In recent years, research in ...
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Article
Current Status of CAR-T Cell Therapy in Multiple Myeloma
(MDPI, 2021-10-21)Current data on CAR-T cell-based therapy is really promising in multiple myeloma, especially in terms of response. In ...
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Delayed administration of ixazomib modifies the immune response and prevents chronic graft-versus-host disease
(Nature Publishing Group, 2021-09-23)In this study, we aimed to modify the immune response in the long term after allogeneic bone marrow transplantation ...
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Differential cytogenetic profile in advanced chronic myeloid leukemia with sequential lymphoblastic and myeloblastic blast crisis
(Elsevier, 2013)Frequency of additional chromosomal abnormalities in chronic myeloid leukemia (CML) is estimated to be 7% in chronic phase ...
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Differential Engraftment of Parental A20 PD-L1 WT and PD-L1 KO Leukemia Cells in Semiallogeneic Recipients in the Context of PD-L1/ PD-1 Interaction and NK Cell Mediated Hybrid Resistance
(FRONTIERS MEDIA SA, 2022)The contribution of natural killer (NK) cells to tumor rejection in the context of programmed death-ligand 1/programmed ...
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ECP versus ruxolitinib in steroid-refractory acute GVHD – a retrospective study by the EBMT transplant complications working party
(Frontiers Media S.A., 2023-12-11)Introduction: Extracorporal Photophoresis (ECP) is in clinical use for steroidrefractory and steroid-dependent acute GVHD ...