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Browsing by Author "Pérez Simón, José Antonio"
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Article
A Conditional Mouse Mutant in the Tumor Suppressor SdhD Gene Unveils a Link between p21(WAF1/Cip1) Induction and Mitochondrial Dysfunction
Díaz Castro, Blanca; García Flores, Gloria Paula; Báez Palomo, Alicia; Millán Uclés, África; Pérez Simón, José Antonio; Piruat Palomo, José Ignacio; López Barneo, José (2014) -
Article
An Active Isodicentric X Chromosome in a Case of Refractory Anaemia with Ring Sideroblasts Associated with Marked Thrombocytosis
Morales Camacho, Rosario María; Sánchez, Javier; Marcos Luque, Irene; Bernal, Ricardo; Falantes, José F.; Pérez Simón, José Antonio (Hindawi, 2014)Refractory anaemia with ring sideroblasts and marked thrombocytosis (RARS-T) is a provisional entity in the World Health ...
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Article
ASXL1 mutation as a surrogate marker in acute myeloid leukemia with myelodysplasia-related changes and normal karyotype
Prats-Martín, Concepción; Burillo-Sanz, Sergio; Morales-Camacho, Rosario M.; Pérez-López, Olga; Suito, Milagros; Vargas de los Monteros, María Teresa; Caballero Velázquez, Teresa; Pérez Simón, José Antonio (Wiley Open Access, 2020)Acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) are poor outcome leukemias. Its diagnosis is based ...
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PhD Thesis
Cambios en los perfiles de expresión génica en condiciones fisiológicas versus patológicas en el sistema hematopoyético
Báez Palomo, Alicia (2014-12-12)El trabajo realizado en esta tesis doctoral consiste en el estudio de los cambios en la expresión génica que sufren las ...
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Article
CD4+ and CD8+ T-cell responses in bone marrow to fatty acids in high-fat diets
Medrano, Mayte; Lemus Conejo, Ana; López Martín, Sergio; Millán-Linares, María del Carmen; Rosillo Ramírez, María de los Ángeles; Muñiz Guinea, Manuel; Calderón Ruíz, Rocío; Pérez Simón, José Antonio; Abia González, María del Rocío (Elsevier, 2022)Obesity is associated with disruptions in the adaptive immune system; however, dietary fatty acids in high-fat diets (HFDs) ...
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Article
Cholinergic signals preserve haematopoietic stem cell quiescence during regenerative haematopoiesis
Fielding, Claire; García García, Andrés; Korn, Claudia; Gadomski, Stephen; Fang, Zijian; Reguera, Juan Luis; Pérez Simón, José Antonio; Göttgens, Berthold; Méndez Ferrer, Simón (Nature Publishing Group, 2022)The sympathetic nervous system has been evolutionary selected to respond to stress and activates haematopoietic stem cells ...
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Article
Clinical benefit of glasdegib plus low-dose cytarabine in patients with de novo and secondary acute myeloid leukemia: long-term analysis of a phase II randomized trial
Heuser, Michael; Smith, B. Douglas; Fiedler, Walter; Sekeres, Mikkael A.; Montesinos, Pau; Leber, Brian; Pérez Simón, José Antonio; Cortes, Jorge E. (Springer, 2021)This analysis from the phase II BRIGHT AML 1003 trial reports the long-term efficacy and safety of glasdegib + ...
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Article
Combined treatment of graft versus host disease using donor regulatory T cells and ruxolitinib
Rodríguez Gil, Alfonso; Escamilla Gómez, Virginia; Nufer, Melanie; Andújar Sánchez, Félix; Lopes Ramos, Teresa; Bejarano García, José Antonio; Caballero Velázquez, Teresa; Villadiego Luque, Francisco Javier; Pérez Simón, José Antonio (Nature Publishing Group, 2022)Donor derived regulatory T lymphocytes and the JAK1/2 kinase inhibitor ruxolitinib are currently being evaluated as ...
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Article
Comparison of outcomes for HLA-matched sibling and haplo identical donors in Myelodysplastic syndromes: report from the chronic malignancies working party of EBMT
Raj, Kavita; Eikema, Dirk Jan; Sheth, Vipul; Koster, Linda; Wreede, Liesbeth C:; Blaise, Didier; Pérez Simón, José Antonio; Yakoub Agha, Ibrahim (Springer Nature, 2022)Myelodysplastic syndromes (MDS) are the second common indication for an Allo-HCT. We compared the outcomes of 1414 matched ...
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Article
Delayed administration of ixazomib modifies the immune response and prevents chronic graft-versus-host disease
Ramos, Teresa L.; García Guerrero, Estefanía; Caballero Velázquez, Teresa; Rodríguez Gil, Alfonso; Caracuel García, Rocío; Nufer, Melanie; Robles Frías, María José; Barbado González, Mª Victoria; Pérez Simón, José Antonio (Nature Publishing Group, 2021-09-23)In this study, we aimed to modify the immune response in the long term after allogeneic bone marrow transplantation ...
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Article
Differential cytogenetic profile in advanced chronic myeloid leukemia with sequential lymphoblastic and myeloblastic blast crisis
Calderón Cabrera, Cristina; Montero, I.; Morales, R. M.; Sánchez, J.; Carrillo, E.; Caballero Velázquez, Teresa; Prats, C.; Bernal, R.; De Blas, J. M.; Pérez Simón, José Antonio (Elsevier, 2013)Frequency of additional chromosomal abnormalities in chronic myeloid leukemia (CML) is estimated to be 7% in chronic phase ...
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Article
Editorial: Regulatory T cells in graft versus host disease
Rodríguez Gil, Alfonso; Pérez Simón, José Antonio; Ritz, Jerome; Lacerda, João F.; Soares, Maria V.D. (Frontiers Media, 2023-02-20)Regulatory T cells (Tregs) are modulators of the immune system that play a key role in maintaining self-tolerance. Treg ...
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PhD Thesis
Efecto inmunomodulador de la vitamina D en el periodo postrasplante alogénico de progenitores hematopoyéticos
Montero Cuadrado, María Isabel (2016-01-22)El presente trabajo de tesis se basa en un ensayo clínico multicéntrico realizado a nivel nacional sobre una población de ...
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Article
Effect of Vitamin D on Graft-versus-Host Disease
Rodríguez Gil, Alfonso; Carrillo-Cruz, Estrella; Marrero-Cepeda, Cristina; Rodríguez, Guillermo; Pérez Simón, José Antonio (MDPI, 2022)The different cell subsets of the immune system express the vitamin D receptor (VDR). Through the VDR, vitamin D exerts ...
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Article
Evaluation of prognostic factors among patients with chronic graft-versus-host disease
Pérez Simón, José Antonio; Afram, Gabriel; Martino, Rodrigo; Piñana, José L.; Caballero Velázquez, Teresa; Ringden, Olle; Valcárcel, D.; Caballero, Dolores; Remberger, Mats; De Paz, Yanira; Sierra, Jordi; San Miguel, Jesús; Hagglund, Hans (Ferrata-Storti Foundation, 2011)Background: Chronic graft-versus-host disease (cGVHD) is a major complication after allogeneic stem cell transplantation ...
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Article
Human Bone Marrow Stromal Cells Differentiate Into Corneal Tissue and Prevent Ocular Graft-Versus-Host Disease in Mice
Sánchez Abarca, Luis Ignacio; Hernández Galilea, Emiliano; Lorenzo, Rebeca; Herrero, Carmen; Verlasco, Almudena; Carrancio, Soraya; Caballero Velázquez, Teresa; Rodríguez Barbosa, José Ignacio; Parrilla, Marta; Del Cañizo, Consuelo; San Miguel, Jesús; Aijón, José; Pérez Simón, José Antonio (SAGE Journals, 2015)Clinical trials have assessed the use of human bone marrow stromal cells (hBMSCs) for the treatment of immune-related ...
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PhD Thesis
Inhibición de la vía de señalización Hedgehog con glasdegib en pacientes con enfermedad injerto contra receptor crónica esclerodermiforme: resultados de un ensayo piloto de fase I/II
Rodríguez Arbolí, Eduardo (2023-03-09)La enfermedad injerto contra receptor crónica esclerodermiforme (EICRcs) se caracteriza por la fibrosis cutánea progresiva ...
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PhD Thesis
Leucemia mieloide aguda con cambios relacionados con mielodisplasia: caracterización citomorfológica, citogenética y molecular, y valor pronóstico de mutaciones en el gen ASXL1
Prats Martín, Concepción (2023-03-02)La clasificación de las leucemias mieloides agudas (LMA) tiene como objeto la definición de entidades con un perfil ...
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PhD Thesis
Linfocitos T reguladores para pacientes con enfermedad injerto contra receptor crónica que no obtienen remisión completa con ruxolitinib
Escamilla Gómez, Virginia (2022-07-06) -
Article
Long-Term Impact of an Educational Antimicrobial Stewardship Program on Management of Patients with Hematological Diseases
Guisado-Gil, Ana Belén; Aguilar-Guisado, Manuela; Peñalva, Germán; Lepe Jiménez, José Antonio; Espigado Tocino, Ildefonso; Rodríguez-Arbolí, Eduardo; Pérez Simón, José Antonio; Cisneros, José Miguel (MDPI, 2021)Antimicrobial stewardship programs (ASPs) in hematological patients are especially relevant. However, information about ...