Now showing items 1-11 of 11

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      Acute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-β Peptide Generation In Vivo 

      Serrano Pozo, Alberto; Sánchez García, Manuel A.; Heras Garvín, Antonio; March Díaz, Rosana Rocío; Navarro Garrido, Victoria; Vizuete Chacón, María Luisa; López Barneo, José; Vitorica Ferrández, Francisco Javier; Pascual, Alberto (Public Library of Science, 2017)
      Background Recent epidemiological evidence has linked hypoxia with the development of Alzheimer disease (AD). A number ...
    • Article
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      Blockade of the Interaction of Calcineurin with FOXO in Astrocytes Protects Against Amyloid-βInduced Neuronal Death 

      Navarro Garrido, Victoria; Vitorica Ferrández, Francisco Javier; Fernández, Ana M.; Hervasa, Rubén; Gómez Gutiérrez, Patricia; Vega, Miguel (IOS Press, 2016)
      Astrocytes actively participate in neuro-inflammatory processes associated to Alzheimer’s disease (AD), and other brain ...
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      Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus 

      Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier; Dávila Cansino, José Carlos; Vizuete Chacón, María Luisa; Carmona Cuenca, Irene; Jiménez Muñoz, Sebastián; Trujillo Estrada, Laura Isabel; Sánchez Varo, Raquel María; Torres Canalejo, Manuel; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria (2012)
      Background: Axonal pathology might constitute one of the earliest manifestations of Alzheimer disease. Axonal dystrophies ...
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      Disruption of Amyloid Plaques Integrity Affects the Soluble Oligomers Content from Alzheimer Disease Brains 

      Jiménez, Sebastián; Navarro Garrido, Victoria; Moyano, Javier; Sánchez Mico, María; Torres, Manuel; Dávila, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (Public Library of Science, 2014)
      The implication of soluble Abeta in the Alzheimer's disease (AD) pathology is currently accepted. In fact, the content of ...
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      Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology 

      Romero Molina, Carmen; Navarro Garrido, Victoria; Sánchez Varo, Raquel María; Jiménez Muñoz, Sebastián; Fernández Valenzuela, Juan José; Sánchez Mico, María; Muñoz Castro, Clara; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier; Vizuete Chacón, María Luisa (Frontiers Media Research Foundation, 2018-11-14)
      Microglial cells are crucial players in the pathological process of neurodegenerative diseases, such as Alzheimer’s disease ...
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      Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer’s disease 

      Baglietto-Vargas, David; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Jiménez Muñoz, Sebastián; Trujillo Estrada, Laura; Gómez Arboledas, Ángela; Sánchez Mico, María; Sánchez Varo, Raquel; Vizuete Chacón, María Luisa; Dávila, José Carlos; García Verdugo, José Manuel; Vitorica Ferrández, Francisco Javier; Gutiérrez, Antonia (Nature Research (part of Springer Nature), 2017)
      Alzheimer’s disease is a major neurodegenerative disorder that leads to severe cognitive deficits in the elderly population. ...
    • Final Degree Project
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      Factores de riesgos genético en la enfermedad de alzheimer esporádico 

      García Gamarro, Paula (2019-06)
      La enfermedad de Alzheimer (EA) se ha convertido en una gran preocupación para la población mundial, ya que produce una ...
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      In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer’s disease pathology 

      Trujillo Estrada, Laura Isabel; Jiménez, Sebastián; Castro, Vanessa de; Torres, Manuel; Baglietto-Vargas, David; Moreno González, Inés; Navarro Garrido, Victoria; Sánchez Varo, Raquel María; Sánchez Mejías, Elisabeth; Dávila, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (BioMed Central, 2013)
      Background: Alzheimer’s disease (AD) is characterized by the abnormal accumulation of extracellular beta-amyloid (Abeta) ...
    • Presentation
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      Litio como terapia neuroprotectora en el modelo appsl/ps1m146l de la enfermedad de Alzheimer 

      Trujillo Estrada, Laura Isabel; De Castro, Vanesa; Jiménez Muñoz, Sebastián; Sánchez Varo, Raquel; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Vizuete Chacón, María Luisa; Davila, JC; Vitorica Ferrández, Francisco Javier; Gutiérrez, A. (2013)
      El litio se utiliza desde hace varias décadas en el tratamiento de trastornos bipolares y la depresión, y recientemente se debate su uso potencial en patologías neurodegenerativas como la enfermedad de Alzheimer (AD).
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      Microglia in Alzheimer’s Disease: Activated, Dysfunctional or Degenerative 

      Navarro Garrido, Victoria; Sánchez Mejías, Elisabeth; Jiménez Muñoz, Sebastián; Muñoz Castro, Clara; Sánchez Varo, Raquel María; Dávila, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (Frontiers Media, 2018)
      Microglial activation has been considered a crucial player in the pathological process of multiple human neurodegenerative ...
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      Soluble phospho‑tau from Alzheimer’s disease hippocampus drives microglial degeneration 

      Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Jiménez, Sebastián; Sánchez Mico, María; Sánchez Varo, Raquel; Núñez Díaz, Cristina; Trujillo Estrada, Laura; Dávila, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (Springer (part of Springer Nature): Springer Open Choice Hybrid Journals, 2016)
      The role of microglial cells in the development and progression of Alzheimer’s disease (AD) has not been elucidated. Here, ...