Now showing items 1-11 of 11

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      Acute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-β Peptide Generation In Vivo  [Article]

      Serrano Pozo, Alberto; Sánchez García, Manuel A.; Heras Garvín, Antonio; March Díaz, Rosana Rocío; Navarro Garrido, Victoria; Vizuete Chacón, María Luisa; López Barneo, José; Vitorica Ferrández, Francisco Javier; Pascual, Alberto (Public Library of Science, 2017)
      Background Recent epidemiological evidence has linked hypoxia with the development of Alzheimer disease (AD). A number of in vitro and in vivo studies have reported that hypoxia can induce amyloid-β peptide accumulation ...
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      Blockade of the Interaction of Calcineurin with FOXO in Astrocytes Protects Against Amyloid-βInduced Neuronal Death  [Article]

      Navarro Garrido, Victoria; Vitorica Ferrández, Francisco Javier; Fernández, Ana M.; Hervasa, Rubén; Gómez Gutiérrez, Patricia; Vega, Miguel (IOS Press, 2016)
      Astrocytes actively participate in neuro-inflammatory processes associated to Alzheimer’s disease (AD), and other brain pathologies. We recently showed that an astrocyte-specific intracellular signaling pathway involving ...
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      Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus  [Article]

      Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier; Dávila Cansino, José Carlos; Vizuete Chacón, María Luisa; Carmona Cuenca, Irene; Jiménez Muñoz, Sebastián; Trujillo Estrada, Laura Isabel; Sánchez Varo, Raquel María; Torres Canalejo, Manuel; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria (2012)
      Background: Axonal pathology might constitute one of the earliest manifestations of Alzheimer disease. Axonal dystrophies were observed in Alzheimer’s patients and transgenic models at early ages. These axonal dystrophies ...
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      Disruption of Amyloid Plaques Integrity Affects the Soluble Oligomers Content from Alzheimer Disease Brains  [Article]

      Jiménez, Sebastián; Navarro Garrido, Victoria; Moyano, Javier; Sánchez Mico, María; Torres, Manuel; Dávila, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (Public Library of Science, 2014)
      The implication of soluble Abeta in the Alzheimer's disease (AD) pathology is currently accepted. In fact, the content of soluble extracellular Abeta species, such as monomeric and/or oligomeric Abeta, seems to correlate ...
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      Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology  [Article]

      Romero Molina, Carmen; Navarro Garrido, Victoria; Sánchez Varo, Raquel María; Jiménez Muñoz, Sebastián; Fernández Valenzuela, Juan José; Sánchez Mico, María; Muñoz Castro, Clara; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier; Vizuete Chacón, María Luisa (Frontiers Media Research Foundation, 2018-11-14)
      Microglial cells are crucial players in the pathological process of neurodegenerative diseases, such as Alzheimer’s disease (AD). Microglial response in AD has been principally studied in relation to amyloid-beta pathology ...
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      Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer’s disease  [Article]

      Baglietto-Vargas, David; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Jiménez Muñoz, Sebastián; Trujillo Estrada, Laura; Gómez Arboledas, Ángela; Sánchez Mico, María; Sánchez Varo, Raquel; Vizuete Chacón, María Luisa; Dávila, José Carlos; García Verdugo, José Manuel; Vitorica Ferrández, Francisco Javier; Gutiérrez, Antonia (Nature Research (part of Springer Nature), 2017)
      Alzheimer’s disease is a major neurodegenerative disorder that leads to severe cognitive deficits in the elderly population. Over the past two decades, multiple studies have focused on elucidating the causative factors ...
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      Factores de riesgos genético en la enfermedad de alzheimer esporádico  [Final Degree Work]

      García Gamarro, Paula (2019-06)
      La enfermedad de Alzheimer (EA) se ha convertido en una gran preocupación para la población mundial, ya que produce una pérdida total de la independencia de los enfermos, destruyendo la calidad de vida de las personas que ...
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      In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer’s disease pathology  [Article]

      Trujillo Estrada, Laura Isabel; Jiménez, Sebastián; Castro, Vanessa de; Torres, Manuel; Baglietto-Vargas, David; Moreno González, Inés; Navarro Garrido, Victoria; Sánchez Varo, Raquel María; Sánchez Mejías, Elisabeth; Dávila, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (BioMed Central, 2013)
      Background: Alzheimer’s disease (AD) is characterized by the abnormal accumulation of extracellular beta-amyloid (Abeta) plaques, intracellular hyperphosphorylated tau, progressive synaptic alterations, axonal dystrophies, ...
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      Litio como terapia neuroprotectora en el modelo appsl/ps1m146l de la enfermedad de Alzheimer  [Presentation]

      Trujillo Estrada, Laura Isabel; De Castro, Vanesa; Jiménez Muñoz, Sebastián; Sánchez Varo, Raquel; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Vizuete Chacón, María Luisa; Davila, JC; Vitorica Ferrández, Francisco Javier; Gutiérrez, A. (2013)
      El litio se utiliza desde hace varias décadas en el tratamiento de trastornos bipolares y la depresión, y recientemente se debate su uso potencial en patologías neurodegenerativas como la enfermedad de Alzheimer (AD).
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      Microglia in Alzheimer’s Disease: Activated, Dysfunctional or Degenerative  [Article]

      Navarro Garrido, Victoria; Sánchez Mejías, Elisabeth; Jiménez Muñoz, Sebastián; Muñoz Castro, Clara; Sánchez Varo, Raquel María; Dávila, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (Frontiers Media, 2018)
      Microglial activation has been considered a crucial player in the pathological process of multiple human neurodegenerative diseases. In some of these pathologies, such as Amyotrophic Lateral Sclerosis or Multiple Sclerosis, ...
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      Soluble phospho‑tau from Alzheimer’s disease hippocampus drives microglial degeneration  [Article]

      Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Jiménez, Sebastián; Sánchez Mico, María; Sánchez Varo, Raquel; Núñez Díaz, Cristina; Trujillo Estrada, Laura; Dávila, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (Springer (part of Springer Nature): Springer Open Choice Hybrid Journals, 2016)
      The role of microglial cells in the development and progression of Alzheimer’s disease (AD) has not been elucidated. Here, we demonstrated the existence of a weak microglial response in human AD hippocampus which is in ...