Browsing by Author "Merino Montiel, Penélope"
Now showing items 1-9 of 9
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Article
2-Aminobenzoxazole-appended coumarins as potent and selective inhibitors of tumour-associated carbonic anhydrases
(Taylor & Francis, 2022)We have carried out the design, synthesis, and evaluation of a small library of 2-aminobenzoxazole-appended coumarins as ...
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Article
Carbohydrate-derived bicyclic selenazolines as new dual inhibitors (cholinesterases/OGA) against Alzheimer's disease
(Elsevier, 2022-10)Concerned by the urgent need to explore new approaches for the treatment of Alzheimer's disease, we herein describe the ...
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Article
Conformationally Restricted Glycoconjugates Derived from Arylsulfonamides and Coumarins: New Families of Tumour-Associated Carbonic Anhydrase Inhibitors
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)The involvement of carbonic anhydrases (CAs) in a myriad of biological events makes the development of new inhibitors of ...
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PhD Thesis
Nuevos sistemas de reconocimiento molecular basados en organocalcógenos. Agentes antiparasitarios y antiproliferativos
(2022-07-07)La presente Tesis Doctoral, desarrollada en cotutela entre los grupos de investigación Síntesis y Modificación de Productos ...
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PhD Thesis
Nuevos tio- y selenoderivados de carbohidratos en enfermedades degenerativas: cáncer y Alzheimer
(2022-07-08)En la presente Tesis Doctoral se han desarrollado nuevas familias de compuestos bioactivos frente a enfermedades complejas ...
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Article
Synthesis of unprecedented steroidal spiro heterocycles as potential antiproliferative drugs
(Elsevier, 2018-01-01)Herein we report the straightforward preparation of novel conformationally-restricted steroids from trans-androsterone and ...
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Article
Thio- and selenosemicarbazones as antiprotozoal agents against Trypanosoma cruzi and Trichomonas vaginalis
(Taylor & Francis, 2022)Herein, we report the preparation of a panel of Schiff bases analogues as antiprotozoal agents by modification of the ...
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Article
Trimethylsilylacetonitrile (TMSAN)
(2009)(A) The condensation of TMSAN with ketones in the presence of the catalytic t-Bu-P4 base to give cyanoalkenes has been ...
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Article
Tuning the activity of iminosugars: novel N-alkylated deoxynojirimycin derivatives as strong BuChE inhibitors
(Taylor & Francis Open Access, 2021)We have designed unprecedented cholinesterase inhibitors based on 1-deoxynojirimycin as potential anti-Alzheimer’s agents. ...