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Browsing by Author "Maya Miles, Douglas"
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Article
An improved system for estradiol-dependent regulation of gene expression in yeast
Chávez de Diego, Sebastián; Cebolla Ramírez, Ángel; Arévalo Rodríguez, Miguel; Quintero Carrasco, María José; Maya Miles, Douglas (2007) -
Article
Analysis of Common Pathways and Markers From Non-Alcoholic Fatty Liver Disease to Immune-Mediated Diseases
Gallego Durán, Rocío; Montero-Vallejo, Rocío; Maya Miles, Douglas; Lucena, Ana; Martin, Franz; Ampuero Herrojo, Javier; Romero Gómez, Manuel (Frontiers Media, 2021-11-24)Metabolic associated fatty liver disease (MAFLD) is the most prevalent form of liver disease worldwide, accounting for a ...
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PhD Thesis
Una conexión entre el complejo FACT y progresión de la célula Saccharomyces cerevisiae
Maya Miles, Douglas (2012)The FACT complex is an essential component of eukaryotic ce ... lls able to modify the chromatin structure allowing ...
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Article
Contribution of Liver and Pancreatic Islet Crosstalk to β-Cell Function/Dysfunction in the Presence of Fatty Liver
López-Bermudo, Lucía; Luque Sierra, Amparo; Maya Miles, Douglas; Gallego-Durán, Rocío; Ampuero Herrojo, Javier; Romero Gómez, Manuel (Frontiers Media S.A., 2022)Tissue-to-tissue crosstalk regulates organ function, according to growing data. This phenomenon is relevant for pancreatic ...
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Article
Crosstalk between chromatin structure, cohesin activity and transcription
Maya Miles, Douglas; Andújar, Eloísa; Pérez Alegre, Mónica; Murillo Pineda, Marina; Barrientos Moreno, Marta; Cabello Lobato, María José; Gómez Marín, Elena; Morillo Huesca, Macarena; Prado, Félix (BMC (part of Springer Nature), 2019)Background: A complex interplay between chromatin and topological machineries is critical for genome architec‑ ture and ...
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Article
Detailed stratified GWAS analysis for severe COVID-19 in four European populations
Degenhardt, Frauke; Ellinghaus, David; Juzenas, Simonas; Lerga Jaso, Jon; Wendorff, Mareike; Maya Miles, Douglas; Calderón Sandubete, Enrique José; Morilla Romero de la Osa, Rubén; Franke, Andre (OXFORD UNIV PRESS, 2022)Metabolic associated fatty liver disease (MAFLD) is the most prevalent form of liver disease worldwide, accounting for a ...
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Article
High levels of histones promote whole-genome-duplications and trigger a Swe1WEE1-dependent phosphorylation of Cdc28CDK1
Maya Miles, Douglas; Peñate Salas, Xenia; Sanmartín Olmo, Trinidad; Jourquin, Frederic; Muñoz Centeno, María de la Cruz; Mendoza, Manuel; Simon, Marie-Noelle; Chávez de Diego, Sebastián; Geli, Vincent (eLife Sciences, 2018-03-27)Whole-genome duplications (WGDs) have played a central role in the evolution of genomes and constitute an important source ...
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Article
Impact of a Loss-of-Function Variant in HSD17B13 on Hepatic Decompensation and Mortality in Cirrhotic Patients
Gil Gómez, Antonio; Rojas, Ángela; García Lozano, María R.; Muñoz Hernández, Rocío; Gallego-Durán, Rocío; Maya Miles, Douglas; Ampuero Herrojo, Javier; Romero Gómez, Manuel (MDPI AG, 2022)Abstract: A common splice variant in HSD17B13 (rs72613567:TA) was recently found to be associated with a reduced risk of ...
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Article
Impact of liver injury on the severity of COVID-19: a systematic review with meta-analysis
Ampuero Herrojo, Javier; Sánchez, Yolanda; García-Lozano, María Rosario; Maya Miles, Douglas; Romero Gómez, Manuel (Aran Ediciones S.A., 2021)Background and aims: SARS-CoV-2 is mainly a respiratory virus that has relevant systemic effects. We assessed the impact ...
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Article
Implementing personalized medicine in covid-19 in andalusia: an opportunity to transform the healthcare system
Dopazo, Joaquín; Maya Miles, Douglas; García, Federico; Lorusso, Nicola; Calleja, Miguel Ángel; Pareja, María Jesús; López Miranda, José; Rodríguez-Baño, Jesús; Padillo Ruiz, Francisco Javier; Romero Gómez, Manuel (MDPI, 2021-05-26)The COVID-19 pandemic represents an unprecedented opportunity to exploit the advantages of personalized medicine for the ...
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Article
Liver injury in non-alcoholic fatty liver disease is associated with urea cycle enzyme dysregulation
Gallego Durán, Rocío; Ampuero Herrojo, Javier; Pastor Ramírez, Helena; Álvarez Amor, Leticia; Campo, José Antonio del; Maya Miles, Douglas; Muñoz Hernández, Rocío; Romero Gómez, Manuel (Nature Publishing Group, 2022)The main aim was to evaluate changes in urea cycle enzymes in NAFLD patients and in two preclinical animal models mimicking ...
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Article
Management of NAFLD patients with advanced fibrosis
Maya Miles, Douglas; Ampuero Herrojo, Javier; Gallego Durán, Rocío; Dingianna, Paola; Romero Gómez, Manuel (Wiley-Blackwell, 2021-06-21)The prevalence of non alcoholic fatty liver disease (NAFLD) has increased to 25% in the general population and could double ...
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Article
Systematic review and meta-analysis: analysis of variables influencing the interpretation of clinical trial results in NAFLD
Ampuero Herrojo, Javier; Gallego Durán, Rocío; Maya Miles, Douglas; Montero, Rocío; Gato, Sheila; Rojas, Ángela; Gil, Antonio; Muñoz, Rocío; Romero Gómez, Manuel (SPRINGER, 2022)Background NAFLD clinical trials have shown suboptimal results, particularly for liver fibrosis, despite the robust ...