Browsing by Author "Macías, David"
Now showing items 1-8 of 8
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Article
2-hydroxyglutarate metabolism is altered in an in vivo model of LPS induced endotoxemia
(Frontiers Media, 2020)The metabolic response to endotoxemia closely mimics those seen in sepsis. Here, we show that the urinary excretion of the ...
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Article
Carotid body oxygen sensing and adaptation to hipoxia
(Springer, 2015-09)The carotid body (CB) is the principal arterial chemoreceptor that mediates the hyperventilatory response to hypoxia. Our ...
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Deletion of the von Hippel-Lindau gene causes sympathoadrenal cell death and impairs chemoreceptor-mediated adaptation to hypoxia
(Wiley, 2014-01)Mutations of the von Hippel–Lindau (VHL) gene are associated with pheochromocytomas and paragangliomas, but the role of ...
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Endothelial cell regulation of systemic haemodynamics and metabolism acts through the HIF transcription factors
(SpringerOpen, 2021-06-11)Background The vascular endothelium has important endocrine and paracrine roles, particularly in the regulation of vascular ...
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Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity
(Wiley Open Access, 2020)Pharmacologically active compounds with preferential cytotoxic activity for senescent cells, known as senolytics, can ...
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HIF-2a is essential for carotid body development and function
(eLife Sciences Publications, 2018-04-19)Mammalian adaptation to oxygen flux occurs at many levels, from shifts in cellular metabolism to physiological adaptations ...
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Implanted neural progenitor cells regulate glial reaction to brain injury and establish gap junctions with host glial cells
(Wiley-Blackwell, 2014)Transplantation of neural stem/progenitor cells (NPCs) in the lesioned brain is able to restore morphological and physiological ...
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Targeting HIF2α-ARNT hetero-dimerisation as a novel therapeutic strategy for pulmonary arterial hypertension
(European Respiratory Society, 2021-03-04)Pulmonary arterial hypertension (PAH) is a destructive disease of the pulmonary vasculature often leading to right heart ...