Now showing items 1-8 of 8

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      1–42 b -Amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death  [Article]

      Manterola, L.; Hernando Rodríguez, M.; Ruiz, A.; Jiménez Muñoz, Sebastián (Nature Publishing Group, 2013)
      1–42 b -Amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death L Manterola 1,12 , M Hernando-Rodr ı ́ guez 2,12 , A Ruiz 3,4 , A Apraiz 5 , O Arrizabalaga 5 , L Vello ́ n 6 , E ...
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      Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus  [Article]

      Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier; Dávila Cansino, José Carlos; Vizuete Chacón, María Luisa; Carmona Cuenca, Irene; Jiménez Muñoz, Sebastián; Trujillo Estrada, Laura Isabel; Sánchez Varo, Raquel María; Torres Canalejo, Manuel; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria (2012)
      Background: Axonal pathology might constitute one of the earliest manifestations of Alzheimer disease. Axonal dystrophies were observed in Alzheimer’s patients and transgenic models at early ages. These axonal dystrophies ...
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      Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology  [Article]

      Romero Molina, Carmen; Navarro Garrido, Victoria; Sánchez Varo, Raquel María; Jiménez Muñoz, Sebastián; Fernández Valenzuela, Juan José; Sánchez Mico, María; Muñoz Castro, Clara; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier; Vizuete Chacón, María Luisa (Frontiers Media Research Foundation, 2018-11-14)
      Microglial cells are crucial players in the pathological process of neurodegenerative diseases, such as Alzheimer’s disease (AD). Microglial response in AD has been principally studied in relation to amyloid-beta pathology ...
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      Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer’s disease  [Article]

      Baglietto-Vargas, David; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Jiménez Muñoz, Sebastián; Trujillo Estrada, Laura; Gómez Arboledas, Ángela; Sánchez Mico, María; Sánchez Varo, Raquel; Vizuete Chacón, María Luisa; Dávila, José Carlos; García Verdugo, José Manuel; Vitorica Ferrández, Francisco Javier; Gutiérrez, Antonia (Nature Research (part of Springer Nature), 2017)
      Alzheimer’s disease is a major neurodegenerative disorder that leads to severe cognitive deficits in the elderly population. Over the past two decades, multiple studies have focused on elucidating the causative factors ...
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      Efectos de la acumulación del péptido Beta amiloide en tejido cerebral de ratones PS1xAPP modelos de la Enfermedad de Alzheimer  [PhD Thesis]

      Jiménez Muñoz, Sebastián (2016-01-15)
      Esta enfermedad se ha convertido en el tercer problema de salud más grave en los países desarrollados (detrás de los accidentes cardiovasculares y el cáncer). Existen alrededor de 800.000 enfermos diagnosticados en España ...
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      Litio como terapia neuroprotectora en el modelo appsl/ps1m146l de la enfermedad de Alzheimer  [Presentation]

      Trujillo Estrada, Laura Isabel; De Castro, Vanesa; Jiménez Muñoz, Sebastián; Sánchez Varo, Raquel; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Vizuete Chacón, María Luisa; Davila, JC; Vitorica Ferrández, Francisco Javier; Gutiérrez, A. (2013)
      El litio se utiliza desde hace varias décadas en el tratamiento de trastornos bipolares y la depresión, y recientemente se debate su uso potencial en patologías neurodegenerativas como la enfermedad de Alzheimer (AD).
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      Microglia in Alzheimer’s Disease: Activated, Dysfunctional or Degenerative  [Article]

      Navarro Garrido, Victoria; Sánchez Mejías, Elisabeth; Jiménez Muñoz, Sebastián; Muñoz Castro, Clara; Sánchez Varo, Raquel María; Dávila, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (Frontiers Media, 2018)
      Microglial activation has been considered a crucial player in the pathological process of multiple human neurodegenerative diseases. In some of these pathologies, such as Amyotrophic Lateral Sclerosis or Multiple Sclerosis, ...
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      Neocortical tissue recovery in severe congenital obstructive hydrocephalus after intraventricular administration of bone marrow-derived mesenchymal stem cells  [Article]

      García Bonilla, María; García Martín, María L.; Ojeda Pérez, Betsaida; Muñoz Hernández, Mª Carmen; Vitorica Ferrández, Francisco Javier; Jiménez Muñoz, Sebastián; Cifuentes, Manuel; Santos Ruíz, Leonor; Shumilov, Kirill; Claros, Silvia; Páez González, Patricia; Jiménez, Antonio J. (BMC, 2020)
      BACKGROUND: In obstructive congenital hydrocephalus, cerebrospinal fluid accumulation is associated with high intracranial pressure and the presence of periventricular edema, ischemia/hypoxia, damage of the white matter, ...