Browsing by Author "García Rondón, Ana"
Now showing items 1-12 of 12
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Article
Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability
(Elsevier, 2019)THO/TREX is a conserved complex with a role in messenger ribonucleoprotein biogenesis that links gene expression and genome ...
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Article
Dna-rna hybrids at dsbs interfere with repair by homologous recombination
(eLife Sciences Publications, 2021)DNA double-strand breaks (DSBs) are the most harmful DNA lesions and their repair is crucial for cell viability and genome ...
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PhD Thesis
Elongación de la transcripción en S. cerevisiae el complejo THO y factores relacionados funcionalmente
(2003)La transcripción es el proceso por el cual se copia la información contenida en el DNA, a una molécula de RNA. Se divide ...
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Article
Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage
(Shared Science Publishers OG, 2020)The stability and function of eukaryotic genomes is closely linked to histones and to chromatin structure. The state of ...
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Article
Histone Mutants Separate R Loop Formation from Genome Instability Induction
(Elsevier, 2017)R loops have positive physiological roles, but they can also be deleterious by causing genome instability, and the mechanisms ...
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Article
Molecular evidence that the eukaryotic THO/TREX complex is required for efficient transcription elongation
(American Society for Biochemistry and Molecular Biology Inc., 2003)THO/TREX is a conserved eukaryotic complex formed by the core THO complex plus proteins involved in mRNA metabolism and ...
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PhD Thesis
New factors involved in transcription-associated genome instability
(2019-10-23)El mantenimiento de la integridad del DNA y la transmisión fiel de su información a la descendencia es una prioridad para ...
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PhD Thesis
Papel de la cromatina en la formación de R-loops
(2017-09-08)La inestabilidad genómica es una patología celular asociada a múltiples enfermedades genéticas, incluido el cáncer (Aguilera ...
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Article
The THO Complex as a Paradigm for the Prevention of Cotranscriptional R-Loops
(Cold Spring Harbor Laboratory Press, 2019)Different proteins associate with the nascent RNA and the RNA polymerase (RNAP) to catalyze the transcription cycle and ...
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Article
What causes an RNA-DNA hybrid to compromise genome integrity?
(Elsevier, 2019)Transcription is a source of genome instability that stimulates mutation and recombination. Part of the damage produced ...
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Article
Yeast Sen1 helicase protects the genome from transcription-associated instability
(Elsevier, 2011-01-06)Sen1 of S. cerevisiae is a known component of the NRD complex implicated in transcription termination of nonpolyadenylated ...
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Article
Yra1-bound RNA–DNA hybrids cause orientation-independent transcription– replication collisions and telomere instability
(Cold Spring Harbor Laboratory Press, 2018)R loops are an important source of genome instability, largely due to their negative impact on replication progression. ...