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Browsing by Author "García Rondón, Ana"
Now showing items 1-12 of 12
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Article
Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability
Salas Armenteros, Irene; Barroso Ceballos, Sonia Inés; García Rondón, Ana; Pérez Calero, Mónica; Andújar, Eloísa; Luna Varo, Rosa María; Aguilera López, Andrés (Elsevier, 2019)THO/TREX is a conserved complex with a role in messenger ribonucleoprotein biogenesis that links gene expression and genome ...
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Article
Dna-rna hybrids at dsbs interfere with repair by homologous recombination
Ortega Moreno, Pedro; Mérida Cerro, José Antonio; García Rondón, Ana; Gómez González, Belén; Aguilera López, Andrés (eLife Sciences Publications, 2021)DNA double-strand breaks (DSBs) are the most harmful DNA lesions and their repair is crucial for cell viability and genome ...
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PhD Thesis
Elongación de la transcripción en S. cerevisiae el complejo THO y factores relacionados funcionalmente
García Rondón, Ana (2003)La transcripción es el proceso por el cual se copia la información contenida en el DNA, a una molécula de RNA. Se divide ...
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Article
Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage
Ortega Moreno, Pedro; García Pichardo, Desiré; San Martín Alonso, Marta; García Rondón, Ana; Gómez González, Belén; Aguilera López, Andrés (Shared Science Publishers OG, 2020)The stability and function of eukaryotic genomes is closely linked to histones and to chromatin structure. The state of ...
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Article
Histone Mutants Separate R Loop Formation from Genome Instability Induction
García Pichardo, Desiré; Cañas, Juan C.; García Rubio, María Luisa; Gómez González, Belén; García Rondón, Ana; Aguilera López, Andrés (Elsevier, 2017)R loops have positive physiological roles, but they can also be deleterious by causing genome instability, and the mechanisms ...
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Article
Molecular evidence that the eukaryotic THO/TREX complex is required for efficient transcription elongation
García Rondón, Ana; Jimeno González, Sonia; García Rubio, María Luisa; Aguilera López, Andrés (American Society for Biochemistry and Molecular Biology Inc., 2003)THO/TREX is a conserved eukaryotic complex formed by the core THO complex plus proteins involved in mRNA metabolism and ...
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PhD Thesis
New factors involved in transcription-associated genome instability
Mérida Cerro, José Antonio (2019-10-23)El mantenimiento de la integridad del DNA y la transmisión fiel de su información a la descendencia es una prioridad para ...
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PhD Thesis
Papel de la cromatina en la formación de R-loops
García Pichardo, Desiré (2017-09-08)La inestabilidad genómica es una patología celular asociada a múltiples enfermedades genéticas, incluido el cáncer (Aguilera ...
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Article
The THO Complex as a Paradigm for the Prevention of Cotranscriptional R-Loops
Luna Varo, Rosa María; García Rondón, Ana; Pérez Calero, Carmen; Salas Armenteros, Irene; Aguilera López, Andrés (Cold Spring Harbor Laboratory Press, 2019)Different proteins associate with the nascent RNA and the RNA polymerase (RNAP) to catalyze the transcription cycle and ...
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Article
What causes an RNA-DNA hybrid to compromise genome integrity?
García Rondón, Ana; Aguilera López, Andrés (Elsevier, 2019)Transcription is a source of genome instability that stimulates mutation and recombination. Part of the damage produced ...
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Article
Yeast Sen1 helicase protects the genome from transcription-associated instability
Mischo, Hannah E.; Gómez González, Belén; Grzechnik, Pawel; García Rondón, Ana; Wei, Wu; Steinmetz, Lars; Aguilera López, Andrés; Proudfoot, Nick J. (Elsevier, 2011-01-06)Sen1 of S. cerevisiae is a known component of the NRD complex implicated in transcription termination of nonpolyadenylated ...
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Article
Yra1-bound RNA–DNA hybrids cause orientation-independent transcription– replication collisions and telomere instability
García Rubio, María Luisa; Aguilera, Paula; Lafuente Barquero, Juan; Ruiz, José F.; Simon, Marie-Noelle; Geli, Vincent; García Rondón, Ana; Aguilera López, Andrés (Cold Spring Harbor Laboratory Press, 2018)R loops are an important source of genome instability, largely due to their negative impact on replication progression. ...