Now showing items 1-16 of 16

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      Arginine deprivation alters microglial polarity and synergizes with radiation to eradicate non-arginine-auxotrophic glioblastoma tumors 

      Hajji, Nabil; García Revilla, Juan; Sarmiento Soto, Manuel; Perryman, Richard; Symington, Jake J.; Quarles, Chad C.; Orta Vázquez, Manuel Luis; Mateos Cordero, Santiago; Venero Recio, José Luis; Syed, Nelofer (American Society for Clinical Investigation, 2022)
      New approaches for the management of glioblastoma (GBM) are an urgent and unmet clinical need. Here, we illustrate that the ...
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      Brainiac Caspases: Beyond the Wall of Apoptosis 

      Espinosa Oliva, Ana María; García Revilla, Juan; Alonso Bellido, Isabel María; Burguillos García, Miguel Ángel (Frontiers Media, 2019)
      For the last two decades, caspases, a family of cysteine-aspartic proteases, have evolved from being considered solely as ...
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      Galectin-3 Deletion Reduces LPS and Acute Colitis-Induced Pro-Inflammatory Microglial Activation in the Ventral Mesencephalon 

      Espinosa Oliva, Ana María; García Miranda, Pablo; Alonso Bellido, Isabel María; Carvajal Vázquez, Ana Eloisa; González Rodríguez, Melania; Carrillo Jiménez, Alejandro; García Domínguez, Irene; Vázquez Carretero, María Dolores; García Revilla, Juan; Santiago Pavón, Martiniano; Peral Rubio, María José; Venero Recio, José Luis; Martínez de Pablos, Rocío (Frontiers Media, 2021)
      Parkinson’s disease is a highly prevalent neurological disorder for which there is currently no cure. Therefore, the ...
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      Galectin-3 shapes toxic alpha-synuclein strains in Parkinson's disease. 

      García Revilla, Juan; Boza Serrano, Antonio; Jin, Yiyun; Vadukul, Devkee M.; Soldán Hidalgo, Jesús; Camprubí Ferrer, Lluís; Ruiz Laza, Rocío; Venero Recio, José Luis (Springer, 2023)
      Parkinson’s Disease (PD) is a neurodegenerative and progressive disorder characterised by intracytoplasmic inclusions ...
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      Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration 

      García Revilla, Juan; Boza Serrano, Antonio; Espinosa Oliva, Ana María; Sarmiento Soto, Manuel; Deierborg, Tomas; Ruiz Laza, Rocío; Martínez de Pablos, Rocío; Burguillos García, Miguel Ángel; Venero Recio, José Luis (Springer Nature, 2022)
      The advent of high-throughput single-cell transcriptomic analysis of microglia has revealed different phenotypes that are ...
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      Galectin‑3, a novel endogenous TREM2 ligand, detrimentally regulates infammatory response in Alzheimer’s disease 

      Boza Serrano, Antonio; Ruíz Laza, Rocio; Sánchez Varo, Raquel María; García Revilla, Juan; Yang, Yiyi; Jiménez Ferrer, Itzia; Jiménez Muñoz, Sebastián; Roca Ceballos, María Angustias; Navarro Garrido, Victoria; Vitorica Ferrández, Francisco Javier; Venero Recio, José Luis; Deierborg, Tomas (Springer, 2019)
      Alzheimer’s disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of ...
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      Hyperinflammation and Fibrosis in Severe COVID-19 Patients: Galectin-3, a Target Molecule to Consider 

      García Revilla, Juan; Deierborg, Tomas; Venero Recio, José Luis; Boza Serrano, Antonio (Frontiers Media, 2020)
      COVID-19 disease have become so far the most important sanitary crisis in the XXI century. In light of the events, any ...
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      Inflammatory Animal Models of Parkinson's Disease 

      García Revilla, Juan; Herrera Carmona, Antonio José; Martínez de Pablos, Rocío; Venero Recio, José Luis (IOS Press, 2022)
      Accumulating evidence suggests that microglia and peripheral immune cells may play determinant roles in the pathogenesis ...
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      Inflammatory bowel disease induces pathologicalα-synucleinaggregation in the human gut and brain 

      Espinosa Oliva, Ana María; Ruiz Laza, Rocío; Sarmiento Soto, Manuel; Boza Serrano, Antonio; Rodríguez Pérez, Ana I; Roca Ceballos, María Angustias; García Revilla, Juan; Santiago Pavón, Martiniano; Carvajal Vázquez, Ana Eloísa; Vázquez Carretero, María Dolores; García Miranda, Pablo; Oliva Martin, María José; Machado Quintana, Alberto; Peral Rubio, María José; Herrera Carmona, Antonio José; Venero Recio, José Luis; Martínez de Pablos, Rocío; neuroinflammation (Wiley, 2024-01-16)
      Aims According to Braak's hypothesis, it is plausible that Parkinson's disease (PD) originates in the enteric nervous ...
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      Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson’s Disease 

      García Domínguez, Irene; Veselá, Karolina; García Revilla, Juan; Carrillo Jiménez, Alejandro; Roca Ceballos, María Angustias; Santiago Pavón, Martiniano; Martínez de Pablos, Rocío; Venero Recio, José Luis (Frontiers Media, 2018)
      The impact of systemic inflammation in nigral dopaminergic cell loss remains unclear. Here, we have investigated the role ...
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      Reformulating Pro-Oxidant Microglia in Neurodegeneration 

      García Revilla, Juan; Alonso Bellido, Isabel María; Burguillos García, Miguel Ángel; Herrera Carmona, Antonio José; Espinosa Oliva, Ana María; Ruiz Laza, Rocío; Cruz Hernández, Luis; García Domínguez, Irene; Roca Ceballos, María Angustias; Santiago Pavón, Martiniano; Rodríguez Gómez, José Antonio; Sarmiento Soto, Manuel; Martínez de Pablos, Rocío; Venero Recio, José Luis (MDPI, 2019)
      In neurodegenerative diseases, microglia-mediated neuroinflammation and oxidative stress are central events. Recent ...
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      Relevance of chronic stress and the two faces of microglia in Parkinson’s disease 

      Herrera Carmona, Antonio José; Espinosa Oliva, Ana María; Carrillo Jiménez, Alejandro; Oliva Martín, María José; García Revilla, Juan; García Quintanilla, Alberto; Martínez de Pablos, Rocío; Venero Recio, José Luis (rontiers Research Foundation, 2015)
      This review is aimed to highlight the importance of stress and glucocorticoids (GCs) in modulating the ...
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      Selective deletion of Caspase-3 gene in the dopaminergic system exhibits autistic-like behaviour 

      García Domínguez, Irene; Suárez Pereira, Irene; Santiago Pavón, Martiniano; Pérez Villegas, Eva M.; Bravo, Lidia; López Martín, Carolina; Roca Ceballos, María Angustias; García Revilla, Juan; Espinosa Oliva, Ana María; Rodríguez Gómez, José Antonio; Joseph, Bertrand; Berrocoso, Esther; Armengol, José Ángel; Venero Recio, José Luis; Ruiz Laza, Rocío; Martínez de Pablos, Rocío (Elsevier, 2021-01-10)
      Apoptotic caspases are thought to play critical roles in elimination of excessive and non-functional synapses and removal ...
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      TET2 Regulates the Neuroinflammatory Response in Microglia 

      Carrillo Jiménez, Alejandro; Ruiz Laza, Rocío; García Domínguez, Irene; García Revilla, Juan; Espinosa Oliva, Ana María; Venero Recio, José Luis; Burguillos García, Miguel Ángel; Tayara, Khadija (Elsevier, 2019)
      Epigenomic mechanisms regulate distinct aspects of the inflammatory response in immune cells. Despite the central role for ...
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      The Absence of Caspase-8 in the Dopaminergic System Leads to Mild Autism-like Behavior 

      Suárez Pereira, Irene; García Domínguez, Irene; Bravo, L.; Santiago Pavón, Martiniano; García Revilla, Juan; Espinosa Oliva, Ana María; Alonso Bellido, Isabel María; López Martín, César; Pérez Villegas, Eva María; Armengol, J. A.; Berrocoso, E.; Venero Recio, José Luis; Martínez de Pablos, Rocío; Ruiz Laza, Rocío (Frontiers Media S.A., 2022)
      In the last decade, new non-apoptotic roles have been ascribed to apoptotic caspases. This family of proteins plays an ...
    • PhD Thesis
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      The role of Galectin-3 in the pathogenesis of Parkinson's Disease 

      García Revilla, Juan (2019-12-20)
      En 1817, James Parkinson describió por primera vez un conjunto de síntomas motores en el ensayo titulado “Shaking Palsy” ...