Browsing by Author "Gaillard, Hélène"
Now showing items 1-12 of 12
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Article
A new connection of mRNP biogenesis and export with transcription-coupled repair
(Oxford University Press, 2007)Although DNA repair is faster in the transcribed strand of active genes, little is known about the possible contribution ...
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Article
A novel class of Mrna-containing cytoplasmic granules are produced in response to UV-irradiation
(American Society for Cell Biology, 2008)Nucleic acids are substrates for different types of damage, but little is known about the fate of damaged RNAs. We addressed ...
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Article
Cleavage factor I links transcription termination to DNA damage response and genome integrity maintenance in Saccharomyces cerevisiae
(Public Library of Science, 2014)During transcription, the nascent pre-mRNA undergoes a series of processing steps before being exported to the cytoplasm. ...
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Article
Gene gating at nuclear pores prevents the formation of R loops
(Taylor and Francis Ltd., 2018)Transcription is an important source of genetic variability. A large amount of transcription-associated genome variation ...
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Article
Genome-wide analysis of factors affecting transcription elongation and DNA repair: a new role for PAF and Ccr4-not in transcription-coupled repair
(Public Library of Science, 2009)RNA polymerases frequently deal with a number of obstacles during transcription elongation that need to be removed for ...
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PhD Thesis
Inestabilidad genética asociada a R-loops.
(2018-07-06)La inestabilidad genómica es una patología celular, la cual se produce cuando una célula acumula variaciones genéticas que ...
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Article
Manganese is a physiologically relevant TORC1 activator in yeast and mammals
(eLife Sciences Publications, 2022)The essential biometal manganese (Mn) serves as a cofactor for several enzymes that are crucial for the prevention of human ...
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Article
Manganese Stress Tolerance Depends on Yap1 and Stress-Activated MAP Kinases
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)Understanding which intracellular signaling pathways are activated by manganese stress is crucial to decipher how metal ...
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Article
Physical proximity of chromatin to nuclear pores prevents harmful R loop accumulation contributing to maintain genome stability
(National Academy of Sciences, 2017)During transcription, the mRNA may hybridize with DNA, forming an R loop, which can be physiological or pathological, ...
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Article
The human nucleoporin Tpr protects cells from RNA-mediated replication stress
(Springer Nature, 2021)Although human nucleoporin Tpr is frequently deregulated in cancer, its roles are poorly understood. Here we show that Tpr ...
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Article
The Nup84 complex coordinates the DNA damage response to warrant genome integrity
(Oxford University Press, 2019)DNA lesions interfere with cellular processes such as transcription and replication and need to be adequately resolved to ...
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Article
Transcription as a Threat to Genome Integrity
(Annual Reviews Inc., 2016)Genomes undergo different types of sporadic alterations, including DNA damage, point mutations, and genome rearrangements, ...