Browsing by Author "Fernández-Chacón, Rafael"
Now showing items 1-19 of 19
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Article
A Poglut1 mutation causes a muscular dystrophy with reduced Notch signaling and satellite cell loss
(Wiley-Blackwell Publishing Ltd., 2016)Skeletal muscle regeneration by muscle satellite cells is a physiological mechanism activated upon muscle damage and ...
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Article
CSP alpha-deficiency causes massive and rapid photoreceptor degeneration
(2006)Cysteine string protein (CSP) _ is an abundant synaptic vesicle protein that contains a DNA-J domain characteristic of ...
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Article
Cysteine String Protein- Prevents Activity-Dependent Degeneration in GABAergic Synapses
(2010)The continuous release of neurotransmitter could be seen to place a persistent burden on presynaptic proteins, one that ...
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Article
Deletion of CASK in mice is lethal and impairs synaptic function
(2007)CASK is an evolutionarily conserved multidomain protein composed of an N-terminal Ca2_/calmodulin-kinase domain, central ...
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PhD Thesis
Estudio del papel de CSPa/DNAJC5 en la función y mantenimiento de las sinapsis glutamatérgicas del hipocampo en ratones adultos
(2023-07-14)La cochaperona sináptica Cysteine String Protein CSP /DNAJC5) se ha implicado en la patogénesis de enfermedades ...
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Article
Examining synaptotagmin 1 function in dense core vesicle exocytosis under direct control of Ca2
(2003)We tested the long-standing hypothesis that synaptotagmin 1 is the Ca2 +_ sensor for fast neurosecretion by analyzing the ...
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Article
Hypoxia induces voltage-dependent Ca2+ entry and quantal dopamine secretion in carotid body glomus cells
(1994)We have investigated the changes of cytosolic [Ca2+1 and the secretory -activity in single glomus cells dispersed from ...
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PhD Thesis
Identificación de una firma inmunohistoquímica con valor predictivo en el carcinoma infiltrante de mama de tipo no especial (NST)
(2015-05-28)Introducción: En la actualidad, el cáncer de mama es la neoplasia maligna más común en la mujer, siendo la causa principal ...
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Article
Increased neurotransmitter release at the neuromuscular junction in a mouse model of polyglutamine disease
(2011)In Huntington’s disease (HD), the expansion of polyglutamine (polyQ) repeats at the N terminus of the ubiquitous protein ...
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Article
Monitoring synaptic function at the neuromuscular junction of a mouse expressing synaptopHluorin
(2007)We monitored presynaptic exocytosis and vesicle recycling at neuromuscular junctions of transgenic mice expressing ...
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Article
Novel SCAMPs Lacking NPF Repeats: Ubiquitous and Synaptic Vesicle-Specific Forms Implicate SCAMPs in Multiple Membrane- Trafficking Functions
(2000)In vertebrates, secretory carrier membrane proteins (SCAMPs) 1–3 constitute a family of putative membrane-trafficking ...
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Article
Oxygen sensing by ion channels and chemotransduction in single glomus cells
(1996)We have monitored cytosolic [Ca2+] and dopamine release in intact fura-2-loaded glomus cells with microfluoroimetry and a ...
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PhD Thesis
Presynaptic calcium dynamics, neuronal excitability and synaptic vesicle Cycle in central synapses lacking cysteine string protein-alpha (CSP-ALPHA).
(2017-12-22)Cysteine String Protein-α (CSP-α) is a molecular co-chaperone of the synaptic vesicles that prevents presynaptic degeneration. ...
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Article
Rab3D Is Not Required for Exocrine Exocytosis but for Maintenance of Normally Sized Secretory Granules
(2002)Rab3D, a member of the Rab3 subfamily of the Rab/ypt GTPases, is expressed on zymogen granules in the pancreas as well as ...
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PhD Thesis
Single‐cell transcriptomic and functional characterization of cortical parvalbumin interneurons in a novel conditional knock‐out mouse lacking CSPα/DNAJC5
(2019-07-05)Neurodegenerative diseases are progressive disorders currently without cure. Indeed, the molecular mechanisms underlying ...
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Article
Structure/Function Analysis of Ca2 + Binding to the C2A Domain of Synaptotagmin 1
(2002)Synaptotagmin 1, a Ca2+ sensor for fast synaptic vesicle exocytosis, contains two C2 domains that form Ca2+ -dependent ...
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Article
Substantia nigra dopaminergic neurons and striatalinterneurons are engaged in three parallel but interdependentpostnatal neurotrophic circuits
(Anatomical Society of Great Britain and Ireland, 2018-06-11)The striatum integrates motor behavior using a well‐defined microcircuit whose individual components are independently ...
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Article
The synaptic vesicle protein CSP alpha prevents presynaptic degeneration
(CELL PRESS, 2004-04-22)Cysteine string protein α (CSPα)—an abundant synaptic vesicle protein that contains a DNA-J domain characteristic of Hsp40 ...
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Article
Two for the Price of One: A Neuroprotective Chaperone Kit within NAD Synthase Protein NMNAT2
(Public Library of Science, 2016-07-25)One of the most fascinating properties of the brain is the ability to function smoothly across decades of a lifespan. ...