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Por motivos de mantenimiento se ha deshabilitado el inicio de sesión temporalmente. Rogamos disculpen las molestias.
Browsing by Author "Fernández-Bolaños Guzmán, José María"
Now showing items 1-20 of 61
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Article
1,4-Dideoxy-1,4-imino-d-arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α-Mannosidase Inhibitors
Haarr, Marianne B.; López López, Óscar; Pejov, Ljupcho; Fernández-Bolaños Guzmán, José María; Lindbäck, Emil; Sydnes, Magne O. (American Chemical Society, 2020)The synthesis of two polyhydroxylated pyrrolidines as 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) analogues bearing a hydrazide ...
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Article
2-Aminobenzoxazole-appended coumarins as potent and selective inhibitors of tumour-associated carbonic anhydrases
Fuentes Aguilar, Alma; Merino Montiel, Penélope; Montiel Smith, Sara; Meza Reyes, Socorro; Vega Báez, José Luis; Fernández-Bolaños Guzmán, José María; López López, Óscar (Taylor & Francis, 2022)We have carried out the design, synthesis, and evaluation of a small library of 2-aminobenzoxazole-appended coumarins as ...
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Article
A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans
García García, Amalia; Rojas, Sara; Rivas García, Lorenzo; Navarro Hortal, María D.; Romero Márquez, José M.; Fernández-Bolaños Guzmán, José María; López López, Óscar; Rodríguez-Diéguez, Antonio (Royal Society of Chemistry, 2022)A new palladium coordination compound based on gliclazide with the chemical formula [Pd(glz)2] (where glz = gliclazide) ...
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Article
A hybrid of 1-deoxynojirimycin and benzotriazole induces preferential inhibition of butyrylcholinesterase (BuChE) over acetylcholinesterase (AChE).
Evangelista, Tereza Cristina Santos; López López, Óscar; Puerta, Adrián; Fernandes, Miguel X.; Ferreira, Sabrina Baptista; Fernández-Bolaños Guzmán, José María; Lindback, Emil (Taylor and Francis Group, 2022)The synthesis of four heterodimers in which the copper(I)-catalysed azide-alkyne cycloaddition wasemployed to connect a ...
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Article
A Multitarget Approach against Neuroinflammation: Alkyl Substituted Coumarins as Inhibitors of Enzymes Involved in Neurodegeneration
Berrino, Emanuela; Carradori, Simone; Carta, Fabrizio; Melfi, Francesco; Gallorini, Marialucia; Poli, Giulio; Fernández-Bolaños Guzmán, José María; López López, Óscar; Supuran, Claudiu T. (MDPI, 2023-11-25)Neurodegenerative disorders (NDs) include a large range of diseases characterized by neural dysfunction with a multifactorial ...
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Article
A New Peracetylated Oleuropein Derivative Ameliorates Joint Inflammation and Destruction in a Murine Collagen-Induced Arthritis Model via Activation of the Nrf-2/Ho-1 Antioxidant Pathway and Suppression of MAPKs and NF-κB Activation
Castejón Martínez, María Luisa; Alarcón de la Lastra Romero, Catalina; Rosillo Ramírez, María de los Ángeles; Montoya García, Tatiana; Fernández-Bolaños Guzmán, José María; González Benjumea, Alejandro; Sánchez Hidalgo, Marina (MDPI, 2021-01)Oleuropein (OL), an olive tree secoiridoid and its peracetylated derivate (Per-OL) haveexhibited several beneficial effects ...
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Article
A Straightforward Access to New Families of Lipophilic Polyphenols by Using Lipolytic Bacteria
Sánchez Barrionuevo, Leyre; González Benjumea, Alejandro; Escobar Niño, Almudena; García Gutiérrez, María Teresa; López López, Óscar; Maya Castilla, Inés; Fernández-Bolaños Guzmán, José María; Cánovas López, David; Mellado Durán, María Encarnación (Public Library of Science, 2016)The chemical synthesis of new lipophilic polyphenols with improved properties presents technical difficulties. Here we ...
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Article
Alkoxyamine-cyanoborane adducts: Efficient cyanoborane transfer agents
Márquez, José M.; Martínez Castro, Elisa; Gabrielli, Serena; López López, Óscar; Maya Castilla, Inés; Angulo, Manuel; Álvarez, Eleuterio; Fernández-Bolaños Guzmán, José María (Royal Society of Chemistry, 2011)We report the synthesis of the hitherto unknown zwitterionic alkoxyamino cyanoboranes by reduction of O-alkyloximes with ...
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PhD Thesis
Anticancerosos potenciales esteres sulfónicos y graso D-nanitol
Collantes de Terán Palacios, Fernando (1975-06-28) -
Article
Biotinylated selenocyanates: Potent and selective cytostatic agents
Roldán Peña, Jesús Miguel; Puerta, Adrián; Dinić, Jelena; Jovanović Stojanov, Sofija; González-Bakker, Aday; Hicke, Francisco J.; Mishra, Atreyee; Piyasaengthong, Akkharadet; Maya Castilla, Inés; Walton, James W.; Pešić, Milica; Padrón, José M.; Fernández-Bolaños Guzmán, José María; López López, Óscar (Elsevier, 2023-04)Most of the currently available cytotoxic agents for tackling cancer are devoid of selectivity, thus causing severe ...
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Article
Carbohydrate-derived bicyclic selenazolines as new dual inhibitors (cholinesterases/OGA) against Alzheimer's disease
Velueta Viveros, Martha; Martínez Bailén, Macarena; Puerta, Adrián; Romero Hernández, Laura L.; Křen, Vladimír; Merino Montiel, Penélope; Montiel Smith, Sara; Fernandes, Miguel X.; Moreno Vargas, Antonio José; Padrón, José M.; López López, Óscar; Fernández-Bolaños Guzmán, José María (Elsevier, 2022-10)Concerned by the urgent need to explore new approaches for the treatment of Alzheimer's disease, we herein describe the ...
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Patent. Invention
Cepas bacterianas y sus usos en reacciones de acilación y/o desacilación
Escobar Niño, Almudena; Sánchez Barrionuevo, Leyre; Cánovas López, David; Mellado Durán, Encarnación; González Benjumea, Alejandro; López López, Óscar; Maya Castilla, Inés; Fernández-Bolaños Guzmán, José María (Oficina Española de Patentes y Marcas (OEPM), 2016-08-08)Cepas bacterianas y sus usos en reacciones de acilación y/o desacilación. La presente invención describe cepas microbianas ...
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Patent. Invention
Cepas bacterianas y sus usos en reacciones de acilación y/o desacilación
Escobar Niño, Almudena; Sánchez Barrionuevo, Leyre; Cánovas López, David; Mellado Durán, Encarnación; González Benjumea, Alejandro; López López, Óscar; Maya Castilla, Inés; Fernández-Bolaños Guzmán, José María (Oficina Española de Patentes y Marcas (OEPM), 2016-05-05)Cepas bacterianas y sus usos en reacciones de acilación y/o desacilación. La presente invención describe cepas microbianas ...
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Patent. Invention
Cepas bacterianas y sus usos en reacciones de acilación y/o desacilación
Escobar Niño, Almudena; Sánchez Barrionuevo, Leyre; Cánovas López, David; Mellado Durán, Encarnación; González Benjumea, Alejandro; López López, Óscar; Maya Castilla, Inés; Fernández-Bolaños Guzmán, José María (Oficina Española de Patentes y Marcas (OEPM), 2016-08-08)Cepas bacterianas y sus usos en reacciones de acilación y/o desacilación. La presente invención describe cepas microbianas ...
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Article
Chemoenzymatic synthesis and radical scavenging of sulfated hydroxytyrosol, tyrosol, and acetylated derivatives
Begines Aguilar, Paloma; Biedermann, David; Valentova, Katerina; Petraskova, Lucie; Pelantova, Helena; Maya Castilla, Inés; Fernández-Bolaños Guzmán, José María (American Chemical Society, 2019-07-03)Potential metabolites of bioactive compounds are important for their biological activities and as authentic standards for ...
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Article
Chemoselective Preparation of New Families of Phenolic-Organoselenium Hybrids—A Biological Assessment
Begines Aguilar, Paloma; Martos Delgado, Sergio; Lagunes, Irene; Maya Castilla, Inés; Padrón, José M.; López López, Óscar; Fernández-Bolaños Guzmán, José María (Multidisciplinary Digital Publishing Institute (MDPI), 2022)Being aware of the enormous biological potential of organoselenium and polyphenolic compounds, we have accomplished the ...
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Patent. Invention
Compuestos bioactivos polifenólicos conteniendo azufre o selenio y sus usos
Fernández-Bolaños Guzmán, José María; Maya Castilla, Inés; López García, María Ángeles; Fernández-Bolaños Guzmán, Juan; Rodríguez Gutiérrez, Guillermo; Gómez Carretero, Antonio (Oficina Española de Patentes y Marcas (OEPM), 2013-09-03)Compuestos bioactivos polifenólicos conteniendo azufre o selenio y sus usos. La invención se refiere a compuestos que ...
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PhD Thesis
Compuestos organoselénicos derivados de carbohidratos. Isoselenocianatos, selenoureas y selenoheterociclos
Maza Pérez, Susana (2007-12-20)En esta Tesis Doctoral se ha puesto a punto un procedimiento eficaz de conversión de tioureas derivadas de azúcar en las ...
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Article
Conformationally Restricted Glycoconjugates Derived from Arylsulfonamides and Coumarins: New Families of Tumour-Associated Carbonic Anhydrase Inhibitors
Martínez Montiel, Mónica; Romero Hernández, Laura L.; Giovannuzzi, Simone; Begines Aguilar, Paloma; Puerta, Adrián; Ahuja Casarín, Ana I.; Fernandes, Miguel X.; Merino Montiel, Penélope; Montiel Smith, Sara; Nocentini, Alessio; Padrón, José M.; Supuran, Claudiu T.; Fernández-Bolaños Guzmán, José María; López López, Óscar (Multidisciplinary Digital Publishing Institute (MDPI), 2023)The involvement of carbonic anhydrases (CAs) in a myriad of biological events makes the development of new inhibitors of ...
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Article
Coumarins-lipophilic cations conjugates: Efficient mitocans targeting carbonic anhydrases
Fuentes Aguilar, Alma; González-Bakker, Aday; Jovanović, Mirna; Stojanov, Sofija Jovanović; Puerta, Adrián; Gargano, Adriana; Fernández-Bolaños Guzmán, José María; López López, Óscar (Elsevier, 2024-02-13)Being aware of the need to develop more efficient therapies against cancer, herein we disclose an innovative approach for ...