Browsing by Author "Fernández-Bolaños Guzmán, José María"
Now showing items 1-20 of 41
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Article
1,4-Dideoxy-1,4-imino-d-arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α-Mannosidase Inhibitors
(American Chemical Society, 2020)The synthesis of two polyhydroxylated pyrrolidines as 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) analogues bearing a hydrazide ...
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Article
2-Aminobenzoxazole-appended coumarins as potent and selective inhibitors of tumour-associated carbonic anhydrases
(Taylor & Francis, 2022)We have carried out the design, synthesis, and evaluation of a small library of 2-aminobenzoxazole-appended coumarins as ...
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Article
A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans
(Royal Society of Chemistry, 2022)A new palladium coordination compound based on gliclazide with the chemical formula [Pd(glz)2] (where glz = gliclazide) ...
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Article
A hybrid of 1-deoxynojirimycin and benzotriazole induces preferential inhibition of butyrylcholinesterase (BuChE) over acetylcholinesterase (AChE).
(Taylor and Francis Group, 2022)The synthesis of four heterodimers in which the copper(I)-catalysed azide-alkyne cycloaddition wasemployed to connect a ...
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Article
A New Peracetylated Oleuropein Derivative Ameliorates Joint Inflammation and Destruction in a Murine Collagen-Induced Arthritis Model via Activation of the Nrf-2/Ho-1 Antioxidant Pathway and Suppression of MAPKs and NF-κB Activation
(MDPI, 2021-01)Oleuropein (OL), an olive tree secoiridoid and its peracetylated derivate (Per-OL) haveexhibited several beneficial effects ...
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Article
A Straightforward Access to New Families of Lipophilic Polyphenols by Using Lipolytic Bacteria
(Public Library of Science, 2016)The chemical synthesis of new lipophilic polyphenols with improved properties presents technical difficulties. Here we ...
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Article
Alkoxyamine-cyanoborane adducts: Efficient cyanoborane transfer agents
(Royal Society of Chemistry, 2011)We report the synthesis of the hitherto unknown zwitterionic alkoxyamino cyanoboranes by reduction of O-alkyloximes with ...
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Article
Chemoselective Preparation of New Families of Phenolic-Organoselenium Hybrids—A Biological Assessment
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)Being aware of the enormous biological potential of organoselenium and polyphenolic compounds, we have accomplished the ...
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PhD Thesis
Compuestos organoselénicos derivados de carbohidratos. Isoselenocianatos, selenoureas y selenoheterociclos
(2007-12-20)En esta Tesis Doctoral se ha puesto a punto un procedimiento eficaz de conversión de tioureas derivadas de azúcar en las ...
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Conformationally Restricted Glycoconjugates Derived from Arylsulfonamides and Coumarins: New Families of Tumour-Associated Carbonic Anhydrase Inhibitors
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)The involvement of carbonic anhydrases (CAs) in a myriad of biological events makes the development of new inhibitors of ...
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Article
Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Aβ1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells
(MDPI, 2019)With the lack of available drugs able to prevent the progression of Alzheimer’s disease (AD), the discovery of new ...
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Article
Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase
(Taylor & Francis Open Access, 2021)The synthesis of four tetra-tacrine clusters where the tacrine binding units are attached to a central scaffold via linkers ...
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Article
Encased Gold Nanoparticle Synthesis as a Probe for Oleuropein Self-Assembled Structure Formation
(MDPI, 2020-12)Stable oleuropein-coated gold nanoparticles in aqueous media were synthesized for the first time. Oleuropein (OLE) ...
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PhD Thesis
Feniltio y fenilsulfinil glicósidos: síntesis de análogos de factoes Nod y de y de C-sulfocelobiosas
(1999)La presente Tesis Doctoral se encuadra dentro de los proyectos de investigación sobre Isotiocianato, tioamnio- y ...
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Article
Glucosylpolyphenols as Inhibitors of Aβ-Induced Fyn Kinase Activation and Tau Phosphorylation: Synthesis, Membrane Permeability, and Exploratory Target Assessment within the Scope of Type 2 Diabetes and Alzheimer's Disease
(American Chemical Society, 2020)Despite the rapidly increasing number of patients suffering from type 2 diabetes, Alzheimer's disease, and diabetes-induced ...
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Article
Identification of an acetyl esterase in the supernatant of the environmental strain Bacillus sp. HR21-6
(Elsevier, 2022)Bacillus sp. HR21-6 is capable of the chemo- and regioselective synthesis of lipophilic partially acetylated phenolic ...
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Article
Inhibitory effect of olive phenolic compounds isolated from olive oil by-product on melanosis of shrimps
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)Melanosis is an unsolved problem of the crustacean industry and the cause of great loss of value. This study investigates ...
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Article
Investigation of the Enantioselectivity of Acetylcholinesterase and Butyrylcholinesterase upon Inhibition by Tacrine-iminosugar Heterodimers
(Taylor & Francis, 2023)The copper-catalysed azide-alkyne cycloaddition was applied to prepare three enantiomeric pairs of heterodimers containing ...
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Article
Isolation and identification of minor secoiridoids and phenolic components from thermally treated olive oil by-products
(Elsevier, 2015-11-15)The application of an industrial process based on the hydrothermal treatment of 160 °C/60 min of alperujo, a by-product ...