Browsing by Author "Espinosa Oliva, Ana María"
Now showing items 1-20 of 24
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Article
Brainiac Caspases: Beyond the Wall of Apoptosis
(Frontiers Media, 2019)For the last two decades, caspases, a family of cysteine-aspartic proteases, have evolved from being considered solely as ...
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Article
Chronic stress enhances microglia activation and exacerbates death of nigral dopaminergic neurons under conditions of inflammation
(BioMed Central, 2014)Background: Parkinson’s disease is an irreversible neurodegenerative disease linked to progressive movement disorders and ...
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Article
Divergent Effects of Metformin on an Inflammatory Model of Parkinson’s Disease
(Frontiers Media, 2018)The oral antidiabetic drug metformin is known to exhibit anti-inflammatory properties through activation of AMP kinase, ...
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PhD Thesis
Efecto del tratamiento con metformina en el sistema dopaminérgico nigroestriado: posible implicación en la enfermedad de parkinson.
(2014-09-29)La enfermedad de Parkinson (EP) es un desorden relacionado con la edad caracterizado por la degeneración progresiva de las ...
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Article
Evidences of hydroxytyrosol as an anti-inflammatory agent in Parkinson's disease: insights into the mechanisms of action
(Medknow Publications, 2021) -
Final Degree Project
Factores asociados a la enfermedad de Alzheimer
(2022)La enfermedad de Alzheimer (EA) es la forma más prevalente de demencia senil, la cual se ha convertido en un problema de ...
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Article
Gal3 Plays a Deleterious Role in a Mouse Model of Endotoxemia
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)Lipopolysaccharide (LPS)-induced endotoxemia induces an acute systemic inflammatory response that mimics some important ...
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Article
Galectin-3 Deletion Reduces LPS and Acute Colitis-Induced Pro-Inflammatory Microglial Activation in the Ventral Mesencephalon
(Frontiers Media, 2021)Parkinson’s disease is a highly prevalent neurological disorder for which there is currently no cure. Therefore, the ...
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Article
Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration
(Springer Nature, 2022)The advent of high-throughput single-cell transcriptomic analysis of microglia has revealed different phenotypes that are ...
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Article
Hydroxytyrosol Decreases LPS- and α-Synuclein-Induced Microglial Activation In Vitro
(MDPI, 2020)Neuroinflammation is a common feature shared by neurodegenerative disorders, such as ...
- Final Degree Project
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Article
Inflammatory animal model for parkinson’s disease: the intranigral injection of LPS induced the inflammatory process along with the selective degeneration of nigrostriatal dopaminergic neurons
(A. Conti and A. Lewen, 2011)We have developed an animal model of degeneration of the nigrostriatal dopaminergic neurons, the neuronal system involved in ...
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PhD Thesis
Metformin treatment decreases microglial activation in the in vivo lps model of parkinson's disease.
(2018-11-23)Metformin is a widely used oral antidiabetic drug with known anti-inflammatory properties due to its action on AMP kinase. ...
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Article
Microglia: Agents of the CNS Pro-Inflammatory Response
(Multidisciplinary Digital Publishing Institute (MDPI), 2020)The pro-inflammatory immune response driven by microglia is a key contributor to the pathogenesis of several neurodegenerative ...
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Article
Microglial Caspase-3 is essential for modulating hippocampal neurogenesis.
(Elsevier, 2023)Adult hippocampal neurogenesis (AHN) is a process involved in numerous neurodegenerative diseases. Many researchers have ...
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Article
Peripheral inflammation increases the damage in animal models of nigrostriatal dopaminergic neurodegeneration: Possible implication in parkinson's disease incidence
(Hindawi Publishing Corporation, 2011)Inflammatory processes described in Parkinson’s disease (PD) and its animal models appear to be important in the progression of ...
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Article
Reformulating Pro-Oxidant Microglia in Neurodegeneration
(MDPI, 2019)In neurodegenerative diseases, microglia-mediated neuroinflammation and oxidative stress are central events. Recent ...
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Article
Relevance of chronic stress and the two faces of microglia in Parkinson’s disease
(rontiers Research Foundation, 2015)This review is aimed to highlight the importance of stress and glucocorticoids (GCs) in modulating the ...
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Article
Selective inhibition of HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma
(Springer Nature, 2021)Ewing sarcoma (EWS) is an aggressive bone and soft tissue tumor of children and young adults in which the principal driver ...
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Article
Stress and inflammation: a detrimental combination in the development of neurodegenerative disease
(Smart Science and Technology, 2014)Chronic stress accelerates the appearance of some neurodegenerative disorders, such as Alzheimer’s disease and Parkinson´s ...