Now showing items 1-19 of 19

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      Age-mediated transcriptomic changes in adult mouse substantia nigra  [Article]

      Gao Chen, Lin; Hidalgo-Figueroa, María; Escudero Cuadrado, Luis María; Díaz Martín, Juan; López Barneo, José; Pascual Bravo, Alberto (2013)
      Substantia nigra pars compacta (SNpc) is highly sensitive to normal aging and selectively degenerates in Parkinson’s disease (PD). Until now, molecular mechanisms behind SNpc aging have not been fully investigated using ...
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      ATM specifically mediates repair of double-strand breaks with blocked DNA ends  [Article]

      Álvarez Quilón, Alejandro; Serrano Benítez, Almudena; Ariel Lieberman, Jenna; Quintero Ruiz, Maria Cristina; Sánchez Gutiérrez, Daniel; Escudero Cuadrado, Luis María; Cortés Ledesma, Felipe (Nature Publishing Group, 2014)
      Ataxia telangiectasia is caused by mutations in ATM and represents a paradigm for cancer predisposition and neurodegenerative syndromes linked to deficiencies in the DNA-damage response. The role of ATM as a key regulator ...
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      Author Correction: Scutoids are a geometrical solution to three-dimensional packing of epithelia  [Article]

      Gómez Gálvez, Pedro; Vicente Munuera, Pablo; Tagua Jáñez, Antonio Jesús; Forja, Cristina; Castro Rodríguez, Ana María; Grima Ruiz, Clara Isabel; Bermúdez Gallardo, Marina; Márquez Pérez, Alberto; Escudero Cuadrado, Luis María (Nature Research, 2018)
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      Biotensegrity of the Extracellular Matrix: Physiology, Dynamic Mechanical Balance, and Implications in Oncology and Mechanotherapy  [Article]

      Tadeo Cervera, Irene; Berbegall, Ana Pilar; Escudero Cuadrado, Luis María; Álvaro Naranjo, Tomás; Noguera Salva, Rosa (Frontiers Media, 2014)
      Cells have the capacity to convert mechanical stimuli into chemical changes. This process is based on the tensegrity principle, a mechanism of tensional integrity. To date, this principle has been demonstrated to act in ...
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      Characterising epithelial tissues using persistent entropy  [Presentation]

      Atienza Martínez, María Nieves; Escudero Cuadrado, Luis María; Jiménez Rodríguez, María José; Soriano Trigueros, Manuel (Springer, 2019)
      In this paper, we apply persistent entropy, a novel topological statis- tic, for characterization of images of epithelial tissues. We have found out that persistent entropy is able to summarize topological and geomet- ric ...
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      Dual role of myosin II during Drosophila imaginal disc metamorphosis  [Article]

      Aldaz, Silvia; Escudero Cuadrado, Luis María; Freeman, Matthew (Nature Publishing Group, 2013)
      The motor protein non-muscle myosin II is a major driver of the movements that sculpt three dimensional organs from two dimensional epithelia. The machinery of morphogenesis is well established but the logic of its control ...
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      Epithelial organisation revealed by a network of cellular contacts  [Article]

      Escudero Cuadrado, Luis María; Luciano da Fontoura Costa; Kicheva, Anna; Briscoe, James; Freeman, Matthew; Babu, M. Madan (Nature Publishing Group, 2011)
      The emergence of differences in the arrangement of cells is the first step towards the establishment of many organs. Understanding this process is limited by the lack of systematic characterization of epithelial organisation. ...
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      Epithelial organisation revealed by a network of cellular contacts  [Article]

      Escudero Cuadrado, Luis María; Costa, Luciano da F.; Kicheva, Anna; Briscoe, James; Freeman, Matthew; Babu, Madan (Nature Publishing Group, 2011)
      The emergence of differences in the arrangement of cells is the first step towards the establishment of many organs. Understanding this process is limited by the lack of systematic characterization of epithelial organisation. ...
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      Estudio de la organización compleja de tejidos biológicos usando conceptos matemáticos  [PhD Thesis]

      Sánchez Gutiérrez, Daniel (2015-12-17)
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      Live imaging of Drosophila imaginal disc development  [Article]

      Aldaz, Silvia; Escudero Cuadrado, Luis María; Freeman, Matthew (National Academy of Sciences, 2010)
      Live imaging has revolutionized the analysis of developmental biology over the last few years. The ability to track in real time the dynamic processes that occur at tissue and cellular levels gives a much clearer view of ...
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      Mechanism of G1 arrest in the Drosophila eye imaginal disc  [Article]

      Escudero Cuadrado, Luis María; Freeman, Matthew (2007)
      Background: Most differentiating cells are arrested in G1-phase of the cell cycle and this proliferative quiescence appears important to allow differentiation programmes to be executed. An example occurs in the Drosophila ...
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      Neuromuscular disease classification system  [Article]

      Sáez Manzano, Aurora; Acha Piñero, Begoña; Montero, Sánchez, Adoración; Rivas, Eloy; Escudero Cuadrado, Luis María; Serrano Gotarredona, María del Carmen (Spie-soc photo-optical instrumentation engineers, 2013)
      Diagnosis of neuromuscular diseases is based on subjective visual assessment of biopsies from patients by the pathologist specialist. A system for objective analysis and classification of muscular dystrophies and ...
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      Nintedanib decreases muscle fibrosis and improves muscle function in a murine model of dystrophinopathy  [Article]

      Piñol Jurado, Patricia; Suárez Calvet, Xavier; Fernández Simón, Esther; Gallardo, Eduard; Gómez Gálvez, Pedro; Escudero Cuadrado, Luis María; Díaz Manera, Jordi (Nature Publishing Group, 2018)
      Duchenne muscle dystrophy (DMD) is a genetic disorder characterized by progressive skeletal muscle weakness. Dystrophin deficiency induces instability of the sarcolemma during muscle contraction that leads to muscle necrosis ...
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      Persistent entropy: a scale-invariant topological statistic for analyzing cell arrangements  [Article]

      Atienza Martínez, María Nieves; Escudero Cuadrado, Luis María; Jiménez Rodríguez, María José; Soriano Trigueros, Manuel (Cornell University, 2019)
      In this work, we develop a method for detecting differences in the topological distribution of cells forming epithelial tissues. In particular, we extract topological information from their images using persistent homology ...
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      Quantifiable diagnosis of neuromuscular diseases through network analysis  [Article]

      Serrano Gotarredona, María del Carmen; Acha Piñero, Begoña; Rivas, Eloy; Escudero Cuadrado, Luis María; Sáez Manzano, Aurora; Montero Sánchez, Adoración; Paradas, Carmen; Pascual Bravo, Alberto (2013)
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      Rules of tissue packing involving different cell types: human muscle organization  [Article]

      Sánchez Gutiérrez, Daniel; Sáez Manzano, Aurora; Gómez Gálvez, Pedro; Paradas López, Carmen ‎; Escudero Cuadrado, Luis María (Nature Publishing Group, 2017)
      Natural packed tissues are assembled as tessellations of polygonal cells. These include skeletal muscles and epithelial sheets. Skeletal muscles appear as a mosaic composed of two different types of cells: the “slow” and ...
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      Scutoids are a geometrical solution to three-dimensional packing of epithelia  [Article]

      Gómez Gálvez, Pedro; Vicente Munuera, Pablo; Tagua Jáñez, Antonio; Forja Barbosa, Cristina; Castro Rodríguez, Ana María; Letrán, Marta; Grima Ruiz, Clara Isabel; Bermúdez Gallardo, Marina; Serrano Pérez-Higueras, Óscar; Márquez Pérez, Alberto; Escudero Cuadrado, Luis María (Nature Publishing Group, 2018)
      As animals develop, tissue bending contributes to shape the organs into complex three-dimensional structures. However, the architecture and packing of curved epithelia remains largely unknown. Here we show by means of ...
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      Topological Progression in Proliferating Epithelia Is Driven by a Unique Variation in Polygon Distribution  [Article]

      Sánchez Gutiérrez, Daniel; Sáez Manzano, Aurora; Pascual Bravo, Alberto; Escudero Cuadrado, Luis María (Public Library of Science, 2013)
      Morphogenesis is consequence of lots of small coordinated variations that occur during development. In proliferating stages, tissue growth is coupled to changes in shape and organization. A number of studies have analyzed ...