Browsing by Author "Escudero Cuadrado, Luis María"
Now showing items 1-20 of 34
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Article
A quantitative principle to understand 3D cellular connectivity in epithelial tubes
(Cell Systems, 2022)Apico-basal cell intercalations (scutoids) optimize packing and energy expenditure in curved epithelia. Further consequences ...
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Article
Age-mediated transcriptomic changes in adult mouse substantia nigra
(2013)Substantia nigra pars compacta (SNpc) is highly sensitive to normal aging and selectively degenerates in Parkinson’s disease ...
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Article
ATM specifically mediates repair of double-strand breaks with blocked DNA ends
(Nature Publishing Group, 2014)Ataxia telangiectasia is caused by mutations in ATM and represents a paradigm for cancer predisposition and neurodegenerative ...
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Article
Author Correction: Scutoids are a geometrical solution to three-dimensional packing of epithelia
(Nature Research, 2018) -
Article
Biotensegrity of the Extracellular Matrix: Physiology, Dynamic Mechanical Balance, and Implications in Oncology and Mechanotherapy
(Frontiers Media, 2014)Cells have the capacity to convert mechanical stimuli into chemical changes. This process is based on the tensegrity ...
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Article
CartoCell, a high-content pipeline for 3D image analysis, unveils cell morphology patterns in epithelia
(Elsevier, 2023)Decades of research have not yet fully explained the mechanisms of epithelial self-organization and 3D packing. Single-cell ...
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Presentation
Characterising epithelial tissues using persistent entropy
(Springer, 2019)In this paper, we apply persistent entropy, a novel topological statis- tic, for characterization of images of epithelial ...
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Article
Curvature in Biological Systems: Its Quantification, Emergence, and Implications across the Scales
(John Wiley and Sons Inc, 2023-03-29)Surface curvature both emerges from, and influences the behavior of, living objects at length scales ranging from cell ...
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Article
Dual role of myosin II during Drosophila imaginal disc metamorphosis
(Nature Publishing Group, 2013)The motor protein non-muscle myosin II is a major driver of the movements that sculpt three dimensional organs from two ...
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Article
EpiGraph: an open-source platform to quantify epithelial organization
(Oxford University Press, 2020)Here we present EpiGraph, an image analysis tool that quantifies epithelial organization. Our method combines computational ...
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Article
Epithelial organisation revealed by a network of cellular contacts
(Nature Publishing Group, 2011)The emergence of differences in the arrangement of cells is the first step towards the establishment of many organs. ...
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PhD Thesis
Estudio de la arquitectura epitelial en 3D, su variación natural y la aparición de patrones morfológicos a nivel celular
(2023-07-11)Una de las cuestiones más fascinantes de la Biología del desarrollo es entender cómo los tejidos y órganos adquieren su ...
- PhD Thesis
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Article
Fundamental physical cellular constraints drive self-organization of tissues
(Wiley-Blackwell, 2016)Morphogenesis is driven by small cell shape changes that modulate tissue organization. Apical surfaces of proliferating ...
- PhD Thesis
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Article
Live imaging of Drosophila imaginal disc development
(National Academy of Sciences, 2010)Live imaging has revolutionized the analysis of developmental biology over the last few years. The ability to track in ...
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Article
Local and global changes in cell density induce reorganisation of 3D packing in a proliferating epithelium
(The Company of Biologists, 2024)Tissue morphogenesis is intimately linked to the changes in shape and organisation of individual cells. In curved epithelia, ...
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Article
Mechanics and self-organization in tissue development
(Elsevier, 2021)Self-organization is an all-important feature of living systems that provides the means to achieve specialization and ...
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Article
Mechanism of G1 arrest in the Drosophila eye imaginal disc
(2007)Background: Most differentiating cells are arrested in G1-phase of the cell cycle and this proliferative quiescence appears ...
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PhD Thesis
Mechanisms of epithelial packing in proliferative tissues
(2024-05-02)Tissue morphogenesis is intimately linked with the complex changes that occur in the shape and organization of individual ...