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Browsing by Author "Di Giorgio, Christophe"
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Article
Cell uptake mechanisms of glycosylated cationic pDNA-cyclodextrin nanoparticles
Guilloteau, Nicolas; Bienvenu, Céline; Charrat, Coralie; Jiménez Blanco, José Luis; Díaz Moscoso, Alejandro; Ortiz Mellet, Carmen; García Fernández, José Manuel; Vierling, Pierre; Di Giorgio, Christophe (Royal Society of Chemistry, 2015)The incorporation of carbohydrate functional elements in the architecture of polycationic amphiphilic cyclodextrins (paCDs) ...
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Article
Cyclodextrin-based facial amphiphiles: Assessing the impact of the hydrophilic-lipophilic balance in the self-assembly, DNA complexation and gene delivery capabilities
Pflueger, Iris; Charrat, Coralie; Ortiz Mellet, Carmen; García Fernández, José Manuel; Di Giorgio, Christophe; Benito, Juan M. (Royal Society of Chemistry, 2016)Exhaustive structure–efficacy relationship studies on nonviral gene delivery systems are often hampered by the ill-defined ...
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Article
Cyclodextrin-scaffolded amphiphilic aminoglucoside clusters: self-assembling and gene delivery capabilities
Aguilar Moncayo, Eva M.; Guilloteau, Nicolas; Bienvenu, Céline; Jiménez Blanco, José Luis; Di Giorgio, Christophe; Vierling, Pierre; Benito, Juan M.; Ortiz Mellet, Carmen; García Fernández, José Manuel (Royal Society of Chemistry, 2014)Precise control over the architecture of gene carriers is instrumental to manipulate gene delivery efficiency. Combining ...
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Article
Harmonized tuning of nucleic acid and lectin binding properties with multivalent cyclodextrins for macrophage-selective gene delivery
Méndez Ardoy, Alejandro; Díaz Moscoso, Alejandro; Ortiz Mellet, Carmen; Di Giorgio, Christophe; Vierling, Pierre; Benito, Juan M.; García Fernández, José Manuel (Royal Society of Chemistry, 2015)Polycationic amphiphilic cyclodextrins (paCDs) have been shown to behave as efficient non-viral gene carriers paralleling ...
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Article
Mannosyl-coated nanocomplexes from amphiphilic cyclodextrins and pDNA for site-specific gene delivery
Díaz Moscoso, Alejandro; Guilloteau, Nicolas; Bienvenu, Céline; Méndez Ardoy, Alejandro; Jiménez Blanco, José Luis; Benito Hernández, Juan Manuel; Le Gourriérec, Loïc; Di Giorgio, Christophe; Vierling, Pierre; Defaye, Jacques; Ortiz Mellet, Carmen; García Fernández, José Manuel (Elsevier, 2011-10)Fully homogeneous facial amphiphiles consisting in a cyclodextrin (CD) platform onto which a polycationic cluster and a ...
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Article
Trehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties
Carbajo Gordillo, Ana Isabel; Rodríguez Lavado, Julio; Jiménez Blanco, José Luis; Benito Hernández, Juan Manuel; Di Giorgio, Christophe; Vélaz, Itziar; Tros de Ilarduya, Concepción; Ortiz Mellet, Carmen; García Fernández, José Manuel (The Society, 2019-06-19)An original family of multivalent vectors encompassing gemini and facial amphiphilicity, namely cationic Siamese twin ...
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Article
Trehalose-polyamine/DNA nanocomplexes: impact of vector architecture on cell and organ transfection selectivity
Ortega Caballero, Fernando; Santana Armas, Maria L.; Tros de Ilarduya, Conchita; Di Giorgio, Christophe; Tripier, Raphael; Le Bris, Nathalie; Ollier, Cedric; Ortiz Mellet, Carmen; García Fernández, José Manuel; Jiménez Blanco, José Luis; Méndez Ardoy, Alejandro (Royal Society of Chemistry, 2024-03-05)A novel family of precision-engineered gene vectors with well-defined structures built on trehalose and trehalose-based ...