Now showing items 1-5 of 5

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      Disruption of Amyloid Plaques Integrity Affects the Soluble Oligomers Content from Alzheimer Disease Brains  [Article]

      Jiménez, Sebastián; Navarro Garrido, Victoria; Moyano, Javier; Sánchez Mico, María; Torres, Manuel; Dávila, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (Public Library of Science, 2014)
      The implication of soluble Abeta in the Alzheimer's disease (AD) pathology is currently accepted. In fact, the content of soluble extracellular Abeta species, such as monomeric and/or oligomeric Abeta, seems to correlate ...
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      Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer’s disease  [Article]

      Baglietto-Vargas, David; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Jiménez Muñoz, Sebastián; Trujillo Estrada, Laura; Gómez Arboledas, Ángela; Sánchez Mico, María; Sánchez Varo, Raquel; Vizuete Chacón, María Luisa; Dávila, José Carlos; García Verdugo, José Manuel; Vitorica Ferrández, Francisco Javier; Gutiérrez, Antonia (Nature Research (part of Springer Nature), 2017)
      Alzheimer’s disease is a major neurodegenerative disorder that leads to severe cognitive deficits in the elderly population. Over the past two decades, multiple studies have focused on elucidating the causative factors ...
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      In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer’s disease pathology  [Article]

      Trujillo Estrada, Laura Isabel; Jiménez, Sebastián; Castro, Vanessa de; Torres, Manuel; Baglietto-Vargas, David; Moreno González, Inés; Navarro Garrido, Victoria; Sánchez Varo, Raquel María; Sánchez Mejías, Elisabeth; Dávila, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (BioMed Central, 2013)
      Background: Alzheimer’s disease (AD) is characterized by the abnormal accumulation of extracellular beta-amyloid (Abeta) plaques, intracellular hyperphosphorylated tau, progressive synaptic alterations, axonal dystrophies, ...
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      Microglia in Alzheimer’s Disease: Activated, Dysfunctional or Degenerative  [Article]

      Navarro Garrido, Victoria; Sánchez Mejías, Elisabeth; Jiménez Muñoz, Sebastián; Muñoz Castro, Clara; Sánchez Varo, Raquel María; Dávila, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (Frontiers Media, 2018)
      Microglial activation has been considered a crucial player in the pathological process of multiple human neurodegenerative diseases. In some of these pathologies, such as Amyotrophic Lateral Sclerosis or Multiple Sclerosis, ...
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      Soluble phospho‑tau from Alzheimer’s disease hippocampus drives microglial degeneration  [Article]

      Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Jiménez, Sebastián; Sánchez Mico, María; Sánchez Varo, Raquel; Núñez Díaz, Cristina; Trujillo Estrada, Laura; Dávila, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (Springer (part of Springer Nature): Springer Open Choice Hybrid Journals, 2016)
      The role of microglial cells in the development and progression of Alzheimer’s disease (AD) has not been elucidated. Here, we demonstrated the existence of a weak microglial response in human AD hippocampus which is in ...