Browsing by Author "Cortés Ledesma, Felipe"
Now showing items 1-20 of 21
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Article
An End to a Means: How DNA-End Structure Shapes the Double-Strand Break Repair Process
(Frontiers Media, 2020)Endogenously-arising DNA double-strand breaks (DSBs) rarely harbor canonical 5'-phosphate, 3'-hydroxyl moieties at the ...
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Article
ATM specifically mediates repair of double-strand breaks with blocked DNA ends
(Nature Publishing Group, 2014)Ataxia telangiectasia is caused by mutations in ATM and represents a paradigm for cancer predisposition and neurodegenerative ...
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Article
CDK targets Sae2 to control DNA-end resection and homologous recombination
(Nature Publishing Group, 2008)DNA double-strand breaks (DSBs) are repaired by two principal mechanisms: non-homologous end-joining (NHEJ) and homologous ...
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Article
Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme
(Nature Publishing Group, 2017)Mutations in chromatin modifier genes are frequently associated with neurodevelopmental diseases. We herein demonstrate ...
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Article
Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination
(Oxford University Press, 2013)While regulating the choice between homologous recombination and non-homologous end joining (NHEJ) as mechanisms of ...
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Article
Different genetic requirements for repair of replication-born double-strand breaks by sister-chromatid recombination and break-induced replication
(Oxford University Press, 2007)Homologous recombination (HR) is the major mechanism used to repair double-strand breaks (DSBs) that result from replication, ...
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Article
Divergent Requirement for a DNA Repair Enzyme during Enterovirus Infections
(American Society for Microbiology, 2015-12)Viruses of the Enterovirus genus of picornaviruses, including poliovirus, coxsackievirus B3 (CVB3), and human rhinovirus, ...
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Article
Does tyrosyl DNA phosphodiesterase-2 play a role in hepatitis B virus genome repair?
(Public Library of Science, 2015)Hepatitis B virus (HBV) replication and persistence are sustained by a nuclear episome, the covalently closed circular ...
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Article
Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency
(Springer Nature, 2020)The ATM kinase is a master regulator of the DNA damage response to double-strand breaks (DSBs) and a well-established ...
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PhD Thesis
Global Dynamics of Topoisomerase II Activity
(2022-04-22)DNA topoisomerases are key enzymes in charge of solving topological problems that arise from essential processes of DNA ...
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Article
Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks
(Elsevier, 2015)DNA double-strand breaks (DSBs) elicit the so-called DNA damage response (DDR), largely relying on ataxia telangiectasia ...
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Article
RanBP2-Mediated SUMOylation Promotes Human DNA Polymerase Lambda Nuclear Localization and DNA Repair
(Elsevier, 2020)Cellular DNA is under constant attack by a wide variety of agents, both endogenous and exogenous. To counteract DNA damage, ...
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PhD Thesis
Regulación transcripcional mediada por la DNA topoisomerasa II
(2020-02-18)La topología del DNA condiciona todos los procesos del metabolismo cromosómico y, en especial, la transcripción, ya que ...
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PhD Thesis
Regulation of blocked-DSB repair by DNA-PKcs and ATM kinases
(2019-11-08)Dada la amenaza que suponen las roturas del ADN de doble cadena para la integridad del genoma, conocer los mecanismos ...
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Article
Regulation of human Polλ by ATM-mediated phosphorylation during Non-Homologous End Joining
(Elsevier, 2018)DNA double strand breaks (DSBs) trigger a variety of cellular signaling processes, collectively termed the DNA-damage ...
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PhD Thesis
Reparación postreplicativa de cortes de doble cadena en Saccharomyces Cerevisiae
(2006-07-21)Entendemos como corte de doble cadena (doublé-strand break, DSB) toda interrupción en la continuidad de una molécula de ...
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Article
TDP2 suppresses genomic instability induced by androgens in the epithelial cells of prostate glands
(Wiley-Blackwell, 2020)Androgens stimulate the proliferation of epithelial cells in the prostate by activating topoisomerase 2 (TOP2) and regulating ...
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Article
TDP2-Dependent Non-Homologous End-Joining Protects against Topoisomerase II-Induced DNA Breaks and Genome Instability in Cells and In Vivo
(Public Library of Science, 2013)Anticancer topoisomerase >poisons> exploit the break-and-rejoining mechanism of topoisomerase II (TOP2) to generate ...
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Article
TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage
(American Society for Biochemistry and Molecular Biology, 2011-01-07)Topoisomerase II (Top2) activity involves an intermediate in which the topoisomerase is covalently bound to a DNA double-strand ...
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Article
TDP2/TTRAP Is the Major 5′-Tyrosyl DNA Phosphodiesterase Activity in Vertebrate Cells and Is Critical for Cellular Resistance to Topoisomerase II-induced DNA Damage
(American Society for Biochemistry and Molecular Biology, 2011)Topoisomerase II (Top2) activity involves an intermediate in which the topoisomerase is covalently bound to a DNA double-strand ...