idUS - Browsing by Author "Carmona Asenjo, Ana Teresa"

Article

Discovery of a Potent α ‑ Galactosidase Inhibitor by in Situ Analysis of a Library of Pyrrolizidine − (Thio)urea Hybrid Molecules Generated via Click Chemistry

Elías Rodríguez, María del Pilar; Pingitore, Valeria; Carmona Asenjo, Ana Teresa; Moreno Vargas, Antonio José; Ide, Daisuke; Miyawaki, Shota; Kato, Atsushi; Álvarez González, Eleuterio; Robina Ramírez, Inmaculada (American Chemical Society, 2018)

The parallel synthesis of a 26-membered-library of aromatic/aliphatic-(thio)urea-linked pyrrolizidines followed by in ...

Article

Discovery of human hexosaminidase inhibitors by in situ screening of a library of mono- and divalent pyrrolidine iminosugars

Pingitore, Valeria; Martínez Bailén, Macarena; Carmona Asenjo, Ana Teresa; Mészáros, Zuzana; Kulik, Natalia; Slámová, Kristýna; Křen, Vladimír; Bojarová, Pavla; Robina Ramírez, Inmaculada; Moreno Vargas, Antonio José (Elsevier, 2022)

Two libraries of mono- and dimeric pyrrolidine iminosugars were synthesized by CuAAC and (thio)urea-bond-forming reactions ...

PhD Thesis

Diseño y síntesis de derivados mono- y multivalentes de 1,4-iminociclitoles: estudio de sus propiedades como inhibidores de glicosidasas.

Martínez Bailen, Macarena (2019-04-05)

Article

Experimental and Theoretical Analysis of the Thiol-Promoted Fragmentation of 2-Halo-3-tosyl-oxanorbornadienes

Carranza César, Marina; Carmona Asenjo, Ana Teresa; Navo, Claudio D.; Robina Ramírez, Inmaculada; Fratta, Simone; Newburn, Carlos; Jimenez-Oses, Gonzalo; Moreno Vargas, Antonio José (American Chemical Society, 2023)

2-Halo-3-tosyl-oxanorbornadienes are able to accept two thiol molecules through an initial nucleophilic substitution, ...

Article

Exploring Multi-Subsite Binding Pockets in Proteins: DEEP-STD NMR Fingerprinting and Molecular Dynamics Unveil a Cryptic Subsite at the GM1 Binding Pocket of Cholera Toxin B

Monaco, Serena; Walpole, Samuel; Doukani, Hassan; Nepravishta, Ridvan; Martínez Bailén, Macarena; Carmona Asenjo, Ana Teresa; Ramos Soriano, Francisco Javier; Robina Ramírez, Inmaculada; Angulo Álvarez, Jesús (Wiley, 2020)

Ligand-based NMRtechniquesto studyprotein–ligandinteractionsare potenttoolsin drugdesign.Satura-tiontransfer difference ...

Article

Host-guest interactions between cyclodextrins and surfactants with functional groups at the end of the hydrophobic tail

Martín, Victoria I.; Ostos Marcos, Francisco José; Angulo Álvarez, Manuel; Márquez Cruz, Antonio Marcial; López-Cornejo, María del Pilar; López López, Manuel; Carmona Asenjo, Ana Teresa; Moyá Morán, María Luisa (Elsevier, 2017)

The aim of this work was to investigate the influence of the incorporation of substituents at the end of the hydrophobic ...

Article

Iminosugar-Phosphines as Organocatalysts in the [3 + 2] Cycloaddition of Allenoates and N-Tosylimines

Elías Rodríguez, María del Pilar; Carmona Asenjo, Ana Teresa; Moreno Vargas, Antonio José; Robina Ramírez, Inmaculada (Multidisciplinary Digital Publishing Institute (MDPI), 2022)

Iminosugar derivatives containing a pyrrolidine-phosphine moiety were prepared from carbohydrates and used as catalysts ...

Article

Inter-Ligand STD NMR: An Efficient 1D NMR Approach to Probe Relative Orientation of Ligands in a Multi-Subsite Protein Binding Pocket

Monaco, Serena; Ramírez Cárdenas, Jonathan; Carmona Asenjo, Ana Teresa; Robina Ramírez, Inmaculada; Angulo Álvarez, Jesús (Multidisciplinary Digital Publishing Institute (MDPI), 2022)

In recent years, Saturation Transfer Difference NMR (STD NMR) has been proven to be a powerful and versatile ligand-based ...

Article

Monosaccharides and Analogues from Simple Achiral Unsaturated Compounds

Moreno Vargas, Antonio José; Carmona Asenjo, Ana Teresa; Moreno Clavijo, Elena; Robina Ramírez, Inmaculada (Schweizerische Chemische Gesellschaft, 2011)

We present herein a selection of ingenious methods that have been developed to convert inexpensive furan, pyrrole and unsaturated hydrocarbons into enantiomerically enriched monosaccharides and analogues of biological interest.

PhD Thesis

Preparación, aplicaciones y reactividad de nuevos derivados de iminoazúcares. Síntesis de análogos del FK866 con propiedades anticáncer

Elías Rodríguez, María del Pilar (2017-05-23)

En esta Tesis Doctoral se ha desarrollado la síntesis de nuevos (pirrolidín-2-il)-Ctriazoles con configuración L-fuco ...

Article

Preparation of water-soluble glycopolymers derived from five-membered iminosugars

Martínez Bailen, Macarena; Galbis Fuster, Elsa; Carmona Asenjo, Ana Teresa; Paz Báñez, María Violante de; Robina Ramírez, Inmaculada (Elsevier, 2019-10)

Iminosugars are carbohydrate mimetics that constitute the main group of oligosaccharide processing enzyme inhibitors. ...

PhD Thesis

Reacciones Clic y evaluación in situ para la identificación de inhibidores de glicosidasas

Pingitore, Valeria (2021-07-16)

Los iminoazúcares constituyen la categoría más importante de inhibidores de glicosidasas, sin embargo, su escasa selectividad ...

PhD Thesis

Síntesis estereoselectiva de nuevos furil-aminoácidos y su uso en la preparación de plataformas moleculares y de ligando de biomoléculas

Molina Sanz, Lidia (2009-03-27)

Los polihidroxialquil-heterociclos son intermedios sintéticos muy interesantes para la preparación de productos de interés ...

Article

Stereoselective synthesis of chiral furan amino acid analogues of D- and L-serine from D-sugars

Molina, Lidia; Moreno Vargas, Antonio José; Carmona Asenjo, Ana Teresa; Robina Ramírez, Inmaculada (Georg Thieme Verlag, 2006)

The synthesis of chiral furan amino acid analogues of D - and L -serine is reported. The developed methodology ...

Article

Structural Basis of the Inhibition of GH1 β-glucosidases by Multivalent Pyrrolidine Iminosugars

Martínez Bailén, Macarena; Jiménez Ortega, Elena; Carmona Asenjo, Ana Teresa; Robina Ramírez, Inmaculada; Sanz Aparicio, Julia; Talens Perales, David; Polaina, Julio; Matassini, Camilla; Cardona, Francesca; Moreno Vargas, Antonio José (Elsevier, 2019)

The synthesis of multivalent pyrrolidine iminosugars via CuAAC click reaction between different pyrrolidine-azide derivatives ...

Article

Studies on the Regioselective Rearrangement of Azanorbornanic Aminyl Radicals into 2,8-Diazabicyclo[3.2.1]oct-2-ene Systems

Gil de Montes Rojas, Enrique; Tallarida, Matteo A.; Carmona Asenjo, Ana Teresa; Navo, Claudio D.; Robina Ramírez, Inmaculada; Elías Rodríguez, María del Pilar; Jiménez Oses, Gonzalo; Moreno Vargas, Antonio José (American Chemical Society, 2022)

Aminyl radicals are nitrogen-centered radicals of interest in synthetic strategies involving C–N bond formation due to ...

Article

Syntheses and biological activities of 1,4-iminoalditol derivatives as α-L-fucosidase inhibitors

Moreno Clavijo, Elena; Carmona Asenjo, Ana Teresa; Moreno Vargas, Antonio José; Molina Sanz, Lidia; Robina Ramírez, Inmaculada (Schweizerische Chemische Gesellschaft (Swiss Chemistry Society), 2011)

A review dealing with 1,4-iminoalditol (hydroxylated pyrrolidine) derivatives as inhibitors of α-l-fucosidases including the different synthetic approaches for their preparation as well as their inhibitory properties is presented.

Article

Synthesis and Biological Evaluation of Modified 2-Deoxystreptamine Dimers

Coste, G.; Horlacher, T.; Molina Sanz, Lidia; Moreno Vargas, Antonio José; Carmona Asenjo, Ana Teresa; Robina Ramírez, Inmaculada; Seeberger, P.H.; Gerber-Lemaire, S. (Thieme Publishing; Georg Thieme Verlag, 2011)

Aminoglycosides are powerful antibiotics, but the emergence of resistant bacterial strains has prompted the search for ...

Article

Synthesis and cancer growth inhibitory activities of 2-fatty-alkylated pyrrolidine-3,4-diol derivatives

Elías Rodríguez, María del Pilar; Moreno Clavijo, Elena; Carrión Jiménez, Sebastián; Carmona Asenjo, Ana Teresa; Moreno Vargas, Antonio José; Caffa, I.; Montecucco, F.; Cea, M.; Nencioni, A.; Robina Ramírez, Inmaculada (Arkat USA, 2014)

A series of new amphiphilic pyrrolidines containing dodecyl and oleyl apolar side chains were prepared and evaluated for ...

Article

Synthesis and Structure-activity Relationship of New Nicotinamide Phosphoribosyltransferase Inhibitors with Antitumor Activity on Solid and Haematological Cancer

Fratta, Simone; Biniecka, Paulina; Moreno Vargas, Antonio José; Carmona Asenjo, Ana Teresa; Nahimana, Aimable; Duchosal, Michel A.; Piacente, Francesco; Bruzzone, Santina; Caffa, Irene; Nencioni, Alessio; Robina Ramírez, Inmaculada (Elsevier, 2023)

Cancer cells are highly dependent on Nicotinamide phosphoribosyltransferase (NAMPT) activity for proliferation, therefore ...

Browsing by Author "Carmona Asenjo, Ana Teresa"

Discovery of a Potent α ‑ Galactosidase Inhibitor by in Situ Analysis of a Library of Pyrrolizidine − (Thio)urea Hybrid Molecules Generated via Click Chemistry ﻿

Discovery of human hexosaminidase inhibitors by in situ screening of a library of mono- and divalent pyrrolidine iminosugars ﻿

Diseño y síntesis de derivados mono- y multivalentes de 1,4-iminociclitoles: estudio de sus propiedades como inhibidores de glicosidasas. ﻿

Experimental and Theoretical Analysis of the Thiol-Promoted Fragmentation of 2-Halo-3-tosyl-oxanorbornadienes ﻿

Exploring Multi-Subsite Binding Pockets in Proteins: DEEP-STD NMR Fingerprinting and Molecular Dynamics Unveil a Cryptic Subsite at the GM1 Binding Pocket of Cholera Toxin B ﻿

Host-guest interactions between cyclodextrins and surfactants with functional groups at the end of the hydrophobic tail ﻿

Iminosugar-Phosphines as Organocatalysts in the [3 + 2] Cycloaddition of Allenoates and N-Tosylimines ﻿

Inter-Ligand STD NMR: An Efficient 1D NMR Approach to Probe Relative Orientation of Ligands in a Multi-Subsite Protein Binding Pocket ﻿

Monosaccharides and Analogues from Simple Achiral Unsaturated Compounds ﻿

Preparación, aplicaciones y reactividad de nuevos derivados de iminoazúcares. Síntesis de análogos del FK866 con propiedades anticáncer ﻿

Preparation of water-soluble glycopolymers derived from five-membered iminosugars ﻿

Reacciones Clic y evaluación in situ para la identificación de inhibidores de glicosidasas ﻿

Síntesis estereoselectiva de nuevos furil-aminoácidos y su uso en la preparación de plataformas moleculares y de ligando de biomoléculas ﻿

Stereoselective synthesis of chiral furan amino acid analogues of D- and L-serine from D-sugars ﻿

Structural Basis of the Inhibition of GH1 β-glucosidases by Multivalent Pyrrolidine Iminosugars ﻿

Studies on the Regioselective Rearrangement of Azanorbornanic Aminyl Radicals into 2,8-Diazabicyclo[3.2.1]oct-2-ene Systems ﻿

Syntheses and biological activities of 1,4-iminoalditol derivatives as α-L-fucosidase inhibitors ﻿

Synthesis and Biological Evaluation of Modified 2-Deoxystreptamine Dimers ﻿

Synthesis and cancer growth inhibitory activities of 2-fatty-alkylated pyrrolidine-3,4-diol derivatives ﻿

Synthesis and Structure-activity Relationship of New Nicotinamide Phosphoribosyltransferase Inhibitors with Antitumor Activity on Solid and Haematological Cancer ﻿

Discovery of a Potent α ‑ Galactosidase Inhibitor by in Situ Analysis of a Library of Pyrrolizidine − (Thio)urea Hybrid Molecules Generated via Click Chemistry

Discovery of human hexosaminidase inhibitors by in situ screening of a library of mono- and divalent pyrrolidine iminosugars

Diseño y síntesis de derivados mono- y multivalentes de 1,4-iminociclitoles: estudio de sus propiedades como inhibidores de glicosidasas.

Experimental and Theoretical Analysis of the Thiol-Promoted Fragmentation of 2-Halo-3-tosyl-oxanorbornadienes

Exploring Multi-Subsite Binding Pockets in Proteins: DEEP-STD NMR Fingerprinting and Molecular Dynamics Unveil a Cryptic Subsite at the GM1 Binding Pocket of Cholera Toxin B

Host-guest interactions between cyclodextrins and surfactants with functional groups at the end of the hydrophobic tail

Iminosugar-Phosphines as Organocatalysts in the [3 + 2] Cycloaddition of Allenoates and N-Tosylimines

Inter-Ligand STD NMR: An Efficient 1D NMR Approach to Probe Relative Orientation of Ligands in a Multi-Subsite Protein Binding Pocket

Monosaccharides and Analogues from Simple Achiral Unsaturated Compounds

Preparación, aplicaciones y reactividad de nuevos derivados de iminoazúcares. Síntesis de análogos del FK866 con propiedades anticáncer

Preparation of water-soluble glycopolymers derived from five-membered iminosugars

Reacciones Clic y evaluación in situ para la identificación de inhibidores de glicosidasas

Síntesis estereoselectiva de nuevos furil-aminoácidos y su uso en la preparación de plataformas moleculares y de ligando de biomoléculas

Stereoselective synthesis of chiral furan amino acid analogues of D- and L-serine from D-sugars

Structural Basis of the Inhibition of GH1 β-glucosidases by Multivalent Pyrrolidine Iminosugars

Studies on the Regioselective Rearrangement of Azanorbornanic Aminyl Radicals into 2,8-Diazabicyclo[3.2.1]oct-2-ene Systems

Syntheses and biological activities of 1,4-iminoalditol derivatives as α-L-fucosidase inhibitors

Synthesis and Biological Evaluation of Modified 2-Deoxystreptamine Dimers

Synthesis and cancer growth inhibitory activities of 2-fatty-alkylated pyrrolidine-3,4-diol derivatives

Synthesis and Structure-activity Relationship of New Nicotinamide Phosphoribosyltransferase Inhibitors with Antitumor Activity on Solid and Haematological Cancer