Browsing by Author "Burguillos García, Miguel Ángel"
Now showing items 1-19 of 19
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PhD Thesis
A dual tool. The role of the ripoptosome in phagocytic cell activation and differentiation
(2015-10-19)El término ripoptosoma hace referencia a la plataforma molecular que contiene, entre otras, dos proteínas implicadas en ...
- PhD Thesis
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Article
Brainiac Caspases: Beyond the Wall of Apoptosis
(Frontiers Media, 2019)For the last two decades, caspases, a family of cysteine-aspartic proteases, have evolved from being considered solely as ...
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Article
Cell Death Related Proteins Beyond Apoptosis in the CNS
(Frontiers Media S.A., 2022)Cell death related (CDR) proteins are a diverse group of proteins whose original function was ascribed to apoptotic cell ...
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Final Degree Project
COVID-19: manifestaciones neurológicas asociadas y efectos sobre la neurodegeneración
(2021)El SARS-CoV2 (coronavirus de tipo 2 causante del síndrome respiratorio agudo severo) responsable de la enfermedad COVID-19, ...
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Article
Deletion of caspase-8 in mouse myeloid cells blocks microglia pro-inflammatory activation and confers protection in MPTP neurodegeneration model
(Impact Journals, LLC, 2015)Increasing evidence involves sustained pro-inflammatory microglia activation in the pathogenesis of different neurodegenerative ...
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Article
Effective Knockdown of Gene Expression in Primary Microglia With siRNA and Magnetic Nanoparticles Without Cell Death or Inflammation
(Frontiers Media, 2018)Microglia, the resident immune cells of the brain, have multiple functions in physiological and pathological conditions, ...
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Article
Galectin-3 released in response to traumatic brain injury acts as an alarmin orchestrating brain immune response and promoting neurodegeneration
(Nature, 2017)Traumatic brain injury (TBI) is currently a major cause of morbidity and poor quality of life in Western society, with an ...
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Article
Magnetofection as a new tool to study microglia biology
(Medknow Publications, 2019) -
Article
Microglia-secreted galectin-3 acts as a toll-like receptor 4 ligand and contributes to microglial activation
(2015)Inflammatory response induced by microglia plays a critical role in the demise of neuronal populations in neuroinflammatory ...
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Article
Microglia: Agents of the CNS Pro-Inflammatory Response
(Multidisciplinary Digital Publishing Institute (MDPI), 2020)The pro-inflammatory immune response driven by microglia is a key contributor to the pathogenesis of several neurodegenerative ...
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Article
Neuromelanin activates proinflammatory microglia through a caspase-8-dependent mechanism
(BioMed Central, 2015)Background We have uncovered a caspase-dependent (caspase-8/caspase-3/7) signaling governing microglia activation and ...
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PhD Thesis
Papel de la galectina-3 en la respuesta inmune y en la pérdida neuronal asociada a un modelo murino de daño cerebral traumático.
(2018-07-13)La lesión cerebral traumática (TBI) es actualmente una causa importante de muerte y discapacidad en la sociedad occidental, ...
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Article
Reformulating Pro-Oxidant Microglia in Neurodegeneration
(MDPI, 2019)In neurodegenerative diseases, microglia-mediated neuroinflammation and oxidative stress are central events. Recent ...
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Article
Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia
(Nature Publishing Group, 2014)The activation of microglia, resident immune cells of the central nervous system, and inflammation-mediated neurotoxicity ...
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Article
Spatio-temporal activation of caspase-8 in myeloid cells upon ischemic stroke
(BioMed Central, 2016)Ischemic stroke (caused by thrombosis, embolism or vasoconstriction) lead to the recruitment and activation of immune cells ...
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Article
TET2 Regulates the Neuroinflammatory Response in Microglia
(Elsevier, 2019)Epigenomic mechanisms regulate distinct aspects of the inflammatory response in immune cells. Despite the central role for ...
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Article
The role of Galectin-3 in α-synuclein-induced microglial activation
(BioMed Central, 2014)Background: Parkinson ’ s disease (PD) is the most prevalent neurodegenerative motor disorder. The neuropathology ...