Browsing by Author "Boza Serrano, Antonio"
Now showing items 1-12 of 12
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Article
APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases
(Springer Nature, 2022)ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human polymorphisms, apoE2, apoE3, and ...
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Divergent Effects of Metformin on an Inflammatory Model of Parkinson’s Disease
(Frontiers Media, 2018)The oral antidiabetic drug metformin is known to exhibit anti-inflammatory properties through activation of AMP kinase, ...
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Article
Early-life stress elicits peripheral and brain immune activation differently in wild type and 5xFAD mice in a sex-specific manner
(BMC, 2022)Background The risk of developing Alzheimer’s disease (AD) is modulated by genetic and environmental factors. Early-life ...
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Galectin-3 is elevated in CSF and is associated with A beta deposits and tau aggregates in brain tissue in Alzheimer's disease
(Springer, 2022)Galectin-3 (Gal-3) is a beta-galactosidase binding protein involved in microglial activation in the central nervous ...
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Galectin-3 shapes toxic alpha-synuclein strains in Parkinson's disease.
(Springer, 2023)Parkinson’s Disease (PD) is a neurodegenerative and progressive disorder characterised by intracytoplasmic inclusions ...
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Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration
(Springer Nature, 2022)The advent of high-throughput single-cell transcriptomic analysis of microglia has revealed different phenotypes that are ...
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Galectin‑3, a novel endogenous TREM2 ligand, detrimentally regulates infammatory response in Alzheimer’s disease
(Springer, 2019)Alzheimer’s disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of ...
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Article
Hyperinflammation and Fibrosis in Severe COVID-19 Patients: Galectin-3, a Target Molecule to Consider
(Frontiers Media, 2020)COVID-19 disease have become so far the most important sanitary crisis in the XXI century. In light of the events, any ...
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Microglia-secreted galectin-3 acts as a toll-like receptor 4 ligand and contributes to microglial activation
(2015)Inflammatory response induced by microglia plays a critical role in the demise of neuronal populations in neuroinflammatory ...
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Article
Targeting galectin-3 to counteract spike-phase uncoupling of fast-spiking interneurons to gamma oscillations in Alzheimer’s disease
(2023)Background Alzheimer’s disease (AD) is a progressive multifaceted neurodegenerative disorder for which no disease-modifying ...
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Article
The human bone marrow harbors a CD45− CD11B+ cell progenitor permitting rapid microglia-like cell derivative approaches
(Wiley-Blackwell, 2021)Microglia, the immune sentinel of the central nervous system (CNS), are generated from yolk sac erythromyeloid progenitors ...
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The role of Galectin-3 in α-synuclein-induced microglial activation
(BioMed Central, 2014)Background: Parkinson ’ s disease (PD) is the most prevalent neurodegenerative motor disorder. The neuropathology ...