Browsing by Author "Benito, Juan M."
Now showing items 1-16 of 16
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Book
Aspectos fisiológicos de la remolacha azucarera de siembra otoñal
(Junta de Andalucía, Consejería de Agricultura y Pesca, 2005)Conceptos generales del metabolismo; crecimiento y desarrollo; actividades enzimáticas; niveles de adenilatos; efecto del ...
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Article
Biophysics and protein corona analysis of Janus cyclodextrin-DNA nanocomplexes. Efficient cellular transfection on cancer cells
(Elsevier, 2017)The self-assembling processes underlining the capabilities of facially differentiated (¿Janus¿) polycationic amphiphilic ...
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Article
Chemical and Enzymatic Approaches to Carbohydrate-Derived Spiroketals: Di-D-Fructose Dianhydrides (DFAs)
(MDPI AG, 2008)Di-D-fructose dianhydrides (DFAs) comprise a unique family of stereoisomeric spiro-tricyclic disaccharides formed upon ...
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Article
Cyclodextrin-based facial amphiphiles: Assessing the impact of the hydrophilic-lipophilic balance in the self-assembly, DNA complexation and gene delivery capabilities
(Royal Society of Chemistry, 2016)Exhaustive structure–efficacy relationship studies on nonviral gene delivery systems are often hampered by the ill-defined ...
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Article
Cyclodextrin-scaffolded amphiphilic aminoglucoside clusters: self-assembling and gene delivery capabilities
(Royal Society of Chemistry, 2014)Precise control over the architecture of gene carriers is instrumental to manipulate gene delivery efficiency. Combining ...
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Article
Deciphering of polycationic carbohydrate based non-viral gene delivery agents by ESI-LTQ-Orbitrap using CID/HCD pairwise tandem mass spectrometry
(Royal Society of Chemistry, 2016)For almost three decades, gene therapy has been gaining interest to efficiently treat some severe diseases. In such context, ...
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Article
Development of polycationic amphiphilic cyclodextrin nanoparticles for anticancer drug delivery
(2017)Background: Paclitaxel is a potent anticancer drug that is effective against a wide spectrum of cancers. To overcome its ...
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Patent. Invention
Dimeros de ciclodextrinas y sus derivados, sus procedimientos de preparacion y su utilizacion en particular para la solubilizacion de sustancias farmacologicamente activas
(Organización Mundial de la Propiedad Intelectual (OMPI), 2009-11-11)Compuesto que responde a la fórmula general siguiente: **(Ver fórmula)** en la que: - m representa un número entero igual ...
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Article
Dynamic Control of the Self-Assembling Properties of Cyclodextrins by the Interplay of Aromatic and Host-Guest Interactions
(Frontiers Media, 2019)The presence of a doubly-linked naphthylene clip at the O-2I and O-3II positions in the secondary ring of β-cyclodextrin ...
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Article
Fluorinated chaperone-ß-cyclodextrin formulations for ß-glucocerebrosidase activity enhancement in neuronopathic Gaucher disease
(American Chemical Society, 2017)Amphiphilic glycomimetics encompassing a rigid, undistortable nor-tropane skeleton based on 1,6-anhydro-L-idonojirimycin ...
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Article
Harmonized tuning of nucleic acid and lectin binding properties with multivalent cyclodextrins for macrophage-selective gene delivery
(Royal Society of Chemistry, 2015)Polycationic amphiphilic cyclodextrins (paCDs) have been shown to behave as efficient non-viral gene carriers paralleling ...
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Article
Insights in Cellular Uptake Mechanisms of pDNA-polycationic Amphiphilic Cyclodextrin Nanoparticles (CDplexes)
(Elsevier, 2010)It is generally recognized that the major obstacle to efficient gene delivery is cellular internalization and endosomal ...
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Article
Multiply–linked cyclodextrin–aromatic hybrids: Caps, hinges and clips
(Taylor & Francis, 2019)The judicious combination of shaping and recognition elements in cage-type architectures represents a powerful strategy ...
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Article
NMR study on the stabilization and chiral discrimination of sulforaphane enantiomers and analogues by cyclodextrins
(Elsevier, 2018)Sulforaphane (SFN), a phytochemical isolated from broccoli, is an important antitumoral compound with additional beneficial ...
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Article
Persulfidation proteome reveals the regulation of protein function by hydrogen sulfide in diverse biological processes in Arabidopsis
(Oxford University Press, 2017)Hydrogen sulfide-mediated signaling pathways regulate many physiological and pathophysiological processes in mammalian ...
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Article
Trifaceted Mickey Mouse Amphiphiles for Programmable Self-Assembly, DNA Complexation and Organ-Selective Gene Delivery
(Wiley, 2021)Instilling segregated cationic and lipophilic domains with an angular disposition in a trehalose-based trifaceted macrocyclic ...