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      ATM specifically mediates repair of double-strand breaks with blocked DNA ends  [Article]

      Álvarez Quilón, Alejandro; Serrano Benítez, Almudena; Ariel Lieberman, Jenna; Quintero, Cristina; Sánchez Gutiérrez, Daniel; Escudero Cuadrado, Luis María; Cortés Ledesma, Felipe (Nature Publishing Group, 2014)
      Ataxia telangiectasia is caused by mutations in ATM and represents a paradigm for cancer predisposition and neurodegenerative syndromes linked to deficiencies in the DNA-damage response. The role of ATM as a key regulator ...
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      Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme  [Article]

      Feng, Weijun; Kawauchi, Daisuke; Körkel-Qu, Huiqin; Ariel Lieberman, Jenna; Jimeno González, Silvia; Cortés Ledesma, Felipe (Nature Publishing Group, 2017)
      Mutations in chromatin modifier genes are frequently associated with neurodevelopmental diseases. We herein demonstrate that the chromodomain helicase DNA-binding protein 7 (Chd7), frequently associated with CHARGE syndrome, ...