Now showing items 1-17 of 17

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      Elongation factor 2-diphthamide is critical for translation of two IRES-dependent protein targets, XIAP and FGF2, under oxidative stress conditions  [Article]

      Argüelles Castilla, Sandro; Camandola, Simonetta; Cutler, Roy G.; Ayala Gómez, Antonio (Elsevier, 2013)
      Elongation factor-2 (eEF2) catalyzes the movement of the ribosome along the mRNA. A single histidine residue in eEF2 (H715) is modified to form diphthamide. A role for eEF2 in cellular stress responses is highlighted by ...
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      Folic acid supplementation: some practical aspects  [Article]

      Cano Rodríguez, María Mercedes; Muñoz, Mario F.; Ayala Gómez, Antonio; Argüelles Castilla, Sandro (Federation of Anti-Aging Medicine Societies, 2012)
      Since 1956, when Harman first postulated the free radical theory of aging, numerous studies have been carried out to test the protective action of antioxidants. One of these protective compounds used in antioxidant therapy ...
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      Hialuronic acid in sking aging  [Article]

      Serres, José; Cano Rodríguez, María Mercedes; Muñoz Pinto, Mario Faustino; Argüelles Castilla, Sandro; Ayala Gómez, Antonio (Spanish Society of Anti-Aging Medicine and Longevity, 2016-10)
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      Inflammatory animal model for parkinson’s disease: the intranigral injection of LPS induced the inflammatory process along with the selective degeneration of nigrostriatal dopaminergic neurons  [Article]

      Machado Quintana, Alberto; Herrera Carmona, Antonio José; Venero Recio, José Luis; Santiago Pavón, Martiniano; Martínez de Pablos, Rocío; Espinosa Oliva, Ana María; Argüelles Castilla, Sandro; Sarmiento Soto, Manuel; Delgado Cortés, M.J.; Mauriño, R.; Cano, Josefina (A. Conti and A. Lewen, 2011)
      We have developed an animal model of degeneration of the nigrostriatal dopaminergic neurons, the neuronal system involved in Parkinson’s disease (PD). The implication of neuroinflammat ion on this disease was originally ...
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      Lipid peroxidation: Production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal  [Article]

      Ayala Gómez, Antonio; Muñoz, Mario F.; Argüelles Castilla, Sandro (Hindawi Publishing Corporation, 2014)
      Lipid peroxidation can be described generally as a process under which oxidants such as free radicals attack lipids containing carbon-carbon double bond(s), especially polyunsaturated fatty acids (PUFAs). Over the last ...
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      Molecular Control of the Amount, Subcellular Location and Activity State of Translation Elongation Factor 2 (eEF-2) in Neurons Experiencing Stress  [Article]

      Argüelles Castilla, Sandro; Camandola, Simonetta; Hutchison, Emmette R.; Cutler, Roy G.; Ayala Gómez, Antonio (Eslsevier, 2013)
      Eukaryotic elongation factor 2 (eEF-2) is an important regulator of the protein translation machinery wherein it controls the movement of the ribosome along the mRNA. The activity of eEF-2 is regulated by changes in cellular ...
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      Oxidative stress is increased in critically ill patients according to antioxidant vitamins intake, independent of severity: A cohort study  [Article]

      Abilés, Jimena; Pérez de la Cruz, Antonio Jesús; Castaño, José García; Rodríguez Elvira, Manuel; Aguayo, Eduardo; Moreno Torres, Rosario; Llopis, Juan Emilio; Aranda, Pilar; Argüelles Castilla, Sandro; Ayala Gómez, Antonio; Machado Quintana, Alberto; Planells, Elena María (Springer Science + Business Media, 2006)
      Critically ill patients suffer from oxidative stress caused by reactive oxygen species (ROS) and reactive nitrogen species (RNS). Although ROS/RNS are constantly produced under normal circumstances, critical illness can ...
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      Peripheral inflammation increases the damage in animal models of nigrostriatal dopaminergic neurodegeneration: Possible implication in parkinson's disease incidence  [Article]

      Machado Quintana, Alberto; Herrera Carmona, Antonio José; Venero Recio, José Luis; Santiago Pavón, Martiniano; Martínez de Pablos, Rocío; Villarán, Ruth; Espinosa Oliva, Ana María; Argüelles Castilla, Sandro; Sarmiento Soto, Manuel; Delgado Cortés, M.J.; Mauricio, R.; Cano, Josefina (Hindawi Publishing Corporation, 2011)
      Inflammatory processes described in Parkinson’s disease (PD) and its animal models appear to be important in the progression of the pathogenesis, or even a triggering factor. Here we review that peripheral inflammation ...
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      Physical exercise and myokines  [Article]

      Zumárraga Franco, Javier; Argüelles Castilla, Sandro; Ayala Gómez, Antonio; Cano Rodríguez, María Mercedes (Spanish Society of Anti-Aging Medicine and Longevity, 2019-10)
      Among the types of muscles present in the body is skeletal muscle, which is the one that allows the development of physical activity thanks to the contractile activity of its muscle cells. It is known that physical ...
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      Potential use of adipose tissue stem cells in the control of aging  [Article]

      Muñoz Pinto, Mario Faustino; Zurita Díaz, Francisco; Argüelles Castilla, Sandro; Vázquez, Rocío; Serres, José; Guzmán Chozas, Matías; Guillén Sanz, Remedios; Rodríguez Gómez, José Antonio; Cortés, José Luis; Muñoz Franco, Jaime; Pintor Toro, José Antonio; Cano Rodríguez, María Mercedes; Ayala Gómez, Antonio (Federation of Anti-Aging Medicine Societies, 2012)
      Cell therapy with adult stem cells is a new battle front for the control of aging. Before being used for this purpose, we need to answer several basic questions about the biochemistry and physiology of these cells. This ...
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      Reciclaje celular y envejecimiento  [Final Degree Work]

      Peralbo Calero, Ángela (2019-06)
      El envejecimiento es un proceso biológico que depende en gran medida de la genética, aunque, también se ve determinado por el entorno físico y social que le rodea. Este proceso no solo conlleva un deterioro físico sino que ...
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      Rendimiento académico del alumnado al utilizar nuevas tecnologías para evaluar las competencias en un laboratorio de prácticas  [Chapter of Book]

      Ojeda Murillo, María Luisa; Carrascal Moreno, María Livia; Nogales Bueno, Fátima; Vázquez Carretero, María Dolores; Vázquez Cueto, Carmen María; Calonge Castrillo, María Luisa; Argüelles Castilla, Sandro; Nuñez Abades, Pedro Antonio; Mate Barrero, Alfonso; García Miranda, Pablo (Universidad de Granada, 2017-06)
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      Stress Increases Vulnerability to Inflammation in the Rat Prefrontal Cortex  [Article]

      Martínez de Pablos, Rocío; Fernández Villarán, Ruth; Argüelles Castilla, Sandro; Herrera Carmona, Antonio José; Venero Recio, José Luis; Ayala Gómez, Antonio (Society for Neuroscience, 2006)
      Inflammation could be involved in some neurodegenerative disorders that accompany signs of inflammation. However, because sensitivity to inflammation is not equal in all brain structures, a direct relationship is not clear. ...
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      Targeting mTORs by omega-3 fatty acids: a possible novel therapeutic strategy for neurodegeneration?  [Article]

      Shirooie, Samira; Nabavi, Seyed Fazel; Dehpour, Ahmad R.; Belwal, Tarun; Habtemariam, Solomon; Argüelles Castilla, Sandro; Nabavi, Seyed Mohammad (Elsevier, 2018-09)
      Neurodegenerative diseases (NDs) such as Parkinson's (PD), Alzheimer's (AD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS) cause significant world-wide morbidity and mortality. To date, there is no ...
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      Tratamientos no farmacológicos antienvejecimiento  [Final Degree Work]

      Cañizares Melero,Carmen (2018-09)
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      Treatment with mesenchymal stem cells in an animal model of parkinson´s disease  [Article]

      Naranjo, José Ángel; Ayala Gómez, Antonio; Cano Rodríguez, María Mercedes; Argüelles Castilla, Sandro; Ruiz, Victoria; Muñoz, Mario (Federation of Anti-Aging Medicine Societies, 2015)
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      Uric acid enhances longevity and endurance and protects the brain against ischemia  [Article]

      Cutler, Roy G.; Camandola, Simonetta; Feldman, Neil H.; Seon Yoon, Jeong; Haran, James B.; Argüelles Castilla, Sandro; Mattsona, Mark P. (Elsevier, 2019)
      Among mammals, there is a positive correlation between serum uric acid (UA) levels and life span. Humans have high levels of UA because they lack a functional urate oxidase (UOX) enzyme that is present in shorter lived ...