Browsing by Author "Aguilera López, Andrés"
Now showing items 1-20 of 147
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A CDK-regulated chromatin segregase promoting chromosome replication
(Springer Nature, 2021)The replication of chromosomes during S phase is critical for cellular and organismal function. Replicative stress can ...
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Article
A genome-wide function of THSC/TREX-2 at active genes prevents transcription–replication collisions
(Oxford University Press, 2014)The THSC/TREX-2 complex of Saccharomyces cerevisiae mediates the anchoring of transcribed genes to the nuclear pore, linking ...
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A Meiotic Checkpoint Alters Repair Partner Bias to Permit Inter-sister Repair of Persistent DSBs
(Elsevier B.V., 2019)Accurate meiotic chromosome segregation critically depends on the formation of inter-homolog crossovers initiated by ...
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A new connection of mRNP biogenesis and export with transcription-coupled repair
(Oxford University Press, 2007)Although DNA repair is faster in the transcribed strand of active genes, little is known about the possible contribution ...
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A new interaction between BRCA2 and DDX5 promotes the repair of DNA breaks at transcribed chromatin
(Taylor & Francis, 2021)In a recent report, we have revealed a new interaction between the BRCA2 DNA repair associated protein (BRCA2) and the ...
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Article
A new role for Rrm3 in repair of replication-born DNA breakage by sister chromatid recombination
(Public Library of Science, 2017)Replication forks stall at different DNA obstacles such as those originated by transcription. Fork stalling can lead to ...
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Article
A novel class of Mrna-containing cytoplasmic granules are produced in response to UV-irradiation
(American Society for Cell Biology, 2008)Nucleic acids are substrates for different types of damage, but little is known about the fate of damaged RNAs. We addressed ...
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Article
A role for the Saccharomyces cerevisiae Rtt109 histone acetyltransferase in R-loop homeostasis and associated genome instability
(Genetics Society of America, 2022)The stability of the genome is occasionally challenged by the formation of DNA-RNA hybrids and R-loops, which can be ...
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Article
A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells
(Springer Nature, 2021)BRCA1 or BRCA2 germline mutations predispose to breast, ovarian and other cancers. High-throughput sequencing of tumour ...
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Article
A unified model for the molecular basis of Xeroderma pigmentosum-Cockayne Syndrome
(Taylor & Francis Open, 2015)Nucleotide Excision Repair (NER) is a pathway that removes lesions distorting the DNA helix. The molecular basis of the ...
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Article
Actin nucleators safeguard replication forks by limiting nascent strand degradation
(Oxford University Press, 2023)Accurate genome replication is essential for all life and a key mechanism of disease prevention, underpinned by the ability ...
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Article
Activation-induced cytidine deaminase action is strongly stimulated by mutations of the THO complex
(National Academy of Sciences, 2007)Activation-induced cytidine deaminase (AID) is a B cell enzyme essential for Ig somatic hypermutation and class switch ...
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Article
ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair
(Nature Publishing Group, 2021)The maintenance of genomic stability requires the coordination of multiple cellular tasks upon the appearance of DNA ...
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Article
AID induces double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants
(Public Library of Science, 2011)Transcription of the switch (S) regions of immunoglobulin genes in B cells generates stable R-loops that are targeted by ...
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An hpr1 point mutation that impairs transcription and mRNP biogenesis without increasing recombination
(American Society for Microbiology, 2006)THO/TREX, a conserved eukaryotic protein complex, is a key player at the interface between transcription and mRNP metabolism. ...
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Chapter of Book
Analysis of repair of replication-born double-strand breaks by sister chromatid recombination in yeast
(Elsevier, 2021)The repair of DNA double-strand breaks is crucial for cell viability and the maintenance of genome integrity. When present, ...
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Article
Architecture and nucleic acids recognition mechanism of the THO complex, an mRNP assembly factor
(Wiley-Blackwell, 2012)The THO complex is a key factor in co-transcriptional formation of export-competent messenger ribonucleoprotein particles, ...
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Article
BRCA2 promotes DNA-RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair
(Wiley-Blackwell, 2021)The BRCA2 tumor suppressor is a DNA double-strand break (DSB) repair factor essential for maintaining genome integrity. ...
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Article
Break-induced RNA–DNA hybrids (BIRDHs) in homologous recombination: friend or foe?
(Wiley-Blackwell, 2023)Double-strand breaks (DSBs) are the most harmful DNA lesions, with a strong impact on cell proliferation and genome ...
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C. elegans THSC/TREX-2 deficiency causes replication stress and genome instability
(The Company of Biologists, 2021)Transcription is an essential process of DNA metabolism, yet it makes DNA more susceptible to DNA damage. THSC/TREX-2 is ...