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Por motivos de mantenimiento se ha deshabilitado el inicio de sesión temporalmente. Rogamos disculpen las molestias.
Browsing by Author "Álava Casado, Enrique de"
Now showing items 1-20 of 38
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Article
An inducible ectopic expression system of EWSR1-FLI1 as a tool for understanding Ewing sarcoma oncogénesis
García-Domínguez, Daniel J.; Hontecillas-Prieto, Lourdes; Andrés León, Eduardo; Sánchez-Molina, Sara; Rodríguez-Núñez, Pablo; Morón, Francisco J.; Hajji, Nabil; Mackintosh, Carlos; Álava Casado, Enrique de (Public Library of Science, 2020)The presence of the chimeric EWSR1-FLI1 oncoprotein is the main and initiating event defining Ewing sarcoma (ES). The ...
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Article
An international working group consensus report for the prioritization of molecular biomarkers for Ewing sarcoma
Shulman, David S.; Whittle, Sarah B.; Surdez, Didier; Bailey, Kelly M.; Álava Casado, Enrique de; Yustein, Jason T.; Grohar, Patrick J. (Nature Research, 2022-09-17)The advent of dose intensified interval compressed therapy has improved event-free survival for patients with localized ...
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Article
Both Epimutations and Chromosome Aberrations Affect Multiple Imprinted Loci in Aggressive Wilms Tumors
Pignata, Laura; Palumbo, Orazio; Cerrato, Flavia; Acurzio, Basilia; Álava Casado, Enrique de; Roma, Josep; Verde, Gaetano (MDPI, 2020)The embryonal renal cancer Wilms tumor (WT) accounts for 7% of all children’s malignancies. Its most frequent molecular ...
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Article
Breakthrough Technologies Reshape the Ewing Sarcoma Molecular Landscape
Salguero-Aranda, Carmen; Amaral, Ana Teresa; Olmedo Pelayo, Joaquín; Diaz-Martin, Juan; Álava Casado, Enrique de (MDPI, 2020)Ewing sarcoma is a highly aggressive round cell mesenchymal neoplasm, most often occurring in children and young adults. ...
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Article
Characterizing the invasive tumor front of aggressive uterine adenocarcinoma and leiomyosarcoma
Sanegre, Sabina; Eritja, Núria; Andrea, Carlos de; Díaz-Martín, Juan; Díaz-Lagares, Ángel; Jácome, María Amalia; Salguero-Aranda, Carmen; Álava Casado, Enrique de; Noguera, Rosa (Frontiers Media, 2021)The invasive tumor front (the tumor–host interface) is vitally important in malignant cell progression and metastasis. ...
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Article
Ciclos de mejora docente integrados en Anatomía Patológica: ¿primer paso hacia una enseñanza integrada?
Álava Casado, Enrique de (Universidad de Sevilla, 2018)Nuestra hipótesis es que el aprendizaje de los alumnos mejoraría si se integrasen contenidos de diversas asignaturas y ...
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Article
Clinical performance evaluation of the Idylla (TM) EGFR Mutation Test on formalin-fixed paraffin-embedded tissue of non-small cell lung cáncer
Delgado-García, Mercedes; Weynand, Birgit; Gómez-Izquierdo, Lourdes; Hernández, María José; Blanco, Ángela María; Varela, Mar; Álava Casado, Enrique de; Biscuola, Michele (BMC, 2020)Background: Detection of epidermal growth factor receptor (EGFR) mutations in exons 18-21 is recommended in all patients ...
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Article
Cost-effectiveness analysis of molecular diagnosis by next-generation sequencing versus sequential single testing in metastatic non-small cell lung cancer patients from a south Spanish hospital perspective
Álava Casado, Enrique de; Pareja, María Jesús; Carcedo, David; Arrabal, Natalia; García, José-Francisco; Bernabé-Caro, Reyes (Taylor and Francis LTD, 2022)Background: To assess the cost-effectiveness of using next-generation sequencing (NGS) compared to sequential single-testing ...
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Article
Endoglin and MMP14 Contribute to Ewing Sarcoma Spreading by Modulation of Cell–Matrix Interactions
Puerto-Camacho, Pilar; Díaz-Martín, Juan; Olmedo Pelayo, Joaquín; Bolado Carrancio, Alfonso; Salguero-Aranda, Carmen; Jordán-Pérez, Carmen; Álava Casado, Enrique de (MDPI ; MDPI AG, 2022)Abstract: Endoglin (ENG) is a mesenchymal stem cell (MSC) marker typically expressed by active endothelium. This transmembrane ...
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PhD Thesis
Endoglin in Ewing sarcoma: from the biological relevance to a clinical strategy
Puerto-Camacho, Pilar (2021-06-11)Endoglin (ENG) is a mesenchymal stem cell (MSC) marker highly expressed mainly in active endothelium and certain cancer ...
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Article
Endoglin in the spotlight to treat cáncer
González Muñoz, Teresa; Amaral, Ana Teresa; Puerto-Camacho, Pilar; Peinado, Héctor; Álava Casado, Enrique de (MDPI, 2021-03-20)A spotlight has been shone on endoglin in recent years due to that fact of its potential to serve as both a reliable disease ...
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Article
Epithelioid hemangioendothelioma, an ultra-rare cancer: a consensus paper from the community of experts
Stacchiotti, S.; Miah, A. B.; Frezza, A. M.; Messiou, C.; Morosi, C.; Caraceni, A.; Álava Casado, Enrique de; Gronchi, A. (Elsevier, 2021)Epithelioid hemangioendothelioma (EHE) is an ultra-rare, translocated, vascular sarcoma. EHE clinical behavior is variable, ...
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PhD Thesis
Estudio de los coactivadores transcripcionales TAZ y YAP1 en el sarcoma de Ewing: Implicación en la progresión tumoral e interacción funcional con la proteína de fusión EWS-FLI1
Rodríguez Núñez, Pablo (2019-10-02)La presente tesis doctoral aborda, por primera vez, el papel funcional de los dos efectores finales de la vía Hippo, TAZ ...
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Article
Evaluation of NAB2-STAT6 Fusion Variants and Other Molecular Alterations as Prognostic Biomarkers in a Case Series of 83 Solitary Fibrous Tumors
Salguero-Aranda, Carmen; Martínez-Reguera, Paula; Marcilla, David; Álava Casado, Enrique de; Díaz Martín, Juan (MDPI, 2021-10-19)Risk stratification of solitary fibrous tumor (SFT) patients based on clinicopathological features has limited efficacy, ...
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Article
Ewing Sarcoma Meets Epigenetics, Immunology and Nanomedicine: Moving Forward into Novel Therapeutic Strategies
Sánchez Molina, Sara; Figuerola Bou, Elisabet; Sánchez Margalet, Víctor; Cruz Merino, Luis de la; Mora, Jaume; Álava Casado, Enrique de; García-Domínguez, Daniel J.; Hontecillas Prieto, Lourdes (MDPI, 2022-11-07)Ewing Sarcoma (EWS) is an aggressive bone and soft tissue tumor that mainly affects children, adolescents, and young adults. ...
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Article
Ewing Sarcoma—Diagnosis, Treatment, Clinical Challenges and Future Perspectives
Zöllner, Stefan K.; Amatruda, James F.; Bauer, Sebastian; Collaud, Stéphane; Álava Casado, Enrique de; Dubois, Steven G.; Dirksen, Uta (MDPI, 2021-04-14)Ewing sarcoma, a highly aggressive bone and soft-tissue cancer, is considered a prime example of the paradigms of a ...
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Article
From precision medicine to imprecision medicine through limited diagnostic ability to detect low allelic frequency mutations
Serrano, María José; Expósito Hernández, José; Guerrero, Rosa; López Hidalgo, Javier; Aguilar, Mariano; Lorente, José Antonio; Álava Casado, Enrique de; Garrido Navas, María del Carmen (2020)Routine molecular testing in NSCLC is currently moving beyond the classical EGFR mutational analysis and the evolving ...
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Article
Genetic alterations and deregulation of hippo pathway as a pathogenetic mechanism in bone and soft tissue sarcoma
Salguero-Aranda, Carmen; Olmedo Pelayo, Joaquín; Álava Casado, Enrique de; Amaral, Ana Teresa; Díaz-Martín, Juan (MDPI, 2022)The Hippo pathway is an evolutionarily conserved modulator of developmental biology with a key role in tissue and organ ...
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Article
Hippo pathway effectors YAP1/TAZ induce an EWS-FLI1-opposing gene signature and associate with disease progression in Ewing sarcoma
Rodríguez-Núñez, Pablo; Romero Pérez, Laura; Amaral, Ana T.; Puerto-Camacho, Pilar; Jordán, Carmen; Marcilla, David; Álava Casado, Enrique de; Díaz-Martín, Juan (Wiley, 2020)YAP1 and TAZ (WWTR1) oncoproteins are thefinal transducers of the Hippo tumor suppressor pathway. Deregula-tion of the ...
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Article
HMGA2 overexpression predicts relapse susceptibility of blastemal Wilms tumor patients
Hontecillas Prieto, Lourdes; García-Domínguez, Daniel J.; García Mejías, Rosa; Ramírez Villar, Gema; Sáez, Carmen; Álava Casado, Enrique de (Impact Journals, 2017)Wilms tumor (WT) is an embryonal malignant neoplasm of the kidney that accounts for 6–7% of all childhood cancers. WT ...