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Browsing by Author "Álava Casado, Enrique de"
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Article
Breakthrough Technologies Reshape the Ewing Sarcoma Molecular Landscape
Salguero-Aranda, Carmen; Amaral, Ana Teresa; Olmedo Pelayo, Joaquín; Diaz-Martin, Juan; Álava Casado, Enrique de (MDPI, 2020)Ewing sarcoma is a highly aggressive round cell mesenchymal neoplasm, most often occurring in children and young adults. ...
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Article
Ciclos de mejora docente integrados en Anatomía Patológica: ¿primer paso hacia una enseñanza integrada?
Álava Casado, Enrique de (Universidad de Sevilla, 2018)Nuestra hipótesis es que el aprendizaje de los alumnos mejoraría si se integrasen contenidos de diversas asignaturas y ...
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PhD Thesis
Endoglin in Ewing sarcoma: from the biological relevance to a clinical strategy
Puerto Camacho, María Pilar (2021-06-11)Endoglin (ENG) is a mesenchymal stem cell (MSC) marker highly expressed mainly in active endothelium and certain cancer ...
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Article
Endoglin in the spotlight to treat cáncer
González Muñoz, Teresa; Amaral, Ana Teresa; Puerto-Camacho, Pilar; Peinado, Héctor; Álava Casado, Enrique de (MDPI, 2021-03-20)A spotlight has been shone on endoglin in recent years due to that fact of its potential to serve as both a reliable disease ...
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PhD Thesis
Estudio de los coactivadores transcripcionales TAZ y YAP1 en el sarcoma de Ewing: Implicación en la progresión tumoral e interacción funcional con la proteína de fusión EWS-FLI1
Rodríguez Núñez, Pablo (2019-10-02)La presente tesis doctoral aborda, por primera vez, el papel funcional de los dos efectores finales de la vía Hippo, TAZ ...
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Article
HMGA2 overexpression predicts relapse susceptibility of blastemal Wilms tumor patients
Hontecillas Prieto, Lourdes; García Domínguez, Daniel; García Mejías, Rosa; Ramírez Villar, Gema; Sáez, Carmen; Álava Casado, Enrique de (Impact Journals, 2017)Wilms tumor (WT) is an embryonal malignant neoplasm of the kidney that accounts for 6–7% of all childhood cancers. WT ...
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Article
Multidrug resistance transporter profile reveals MDR3 as a marker for stratification of blastemal Wilms tumour patients
Hontecillas Prieto, Lourdes; García Domínguez, Daniel; Pascual Vaca, Diego; García Mejías, Rosa; Marcilla, David; Ramírez Villar, Gema; Álava Casado, Enrique de (Impact Journals, 2017)Wilms tumour (WT) is the most common renal tumour in children. Most WT patients respond to chemotherapy, but subsets of ...
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Article
Phosphorylated-insulin growth factor I receptor (p-IGF1R) and metalloproteinase-3 (MMP3) expression in advanced gastrointestinal stromal tumors (GIST). A GEIS 19 study
Maurel, Joan; López-Pousa, Antonio; Calabuig, Silvia; Bagué, Silvia; García del Muro, Xavier; Sanjuan, Xavier; Álava Casado, Enrique de (BMC, 2016-06-29)Background: Most GISTs have mutations in KIT or PDGFRA. Patients with advanced GIST with KIT exon 9, PDGFRA mutation or ...
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Article
RING1B contributes to Ewing sarcoma development by repressing the Na(V)1.6 sodium channel and the NF-kappa B pathway, independently of the fusion oncoprotein
Hernández Muñoz, Inmaculada; Figuerola, Elisabeth; Sánchez Molina, Sara; Rodríguez, Eva; Fernández Mariño, María Isabel; Pardo Pastor, Carlos; Álava Casado, Enrique de; Mora, Jaume (Impact Journals, 2016-06-15)Ewing sarcoma (ES) is an aggressive tumor defined by EWSR1 gene fusions that behave as an oncogene. Here we demonstrate ...
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Article
Selective inhibition of HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma
García Domínguez, Daniel; Hajji, Nabil; Sánchez Molina, Sara; Figuerola Bou, Elisabet; Martínez de Pablos, Rocío; Espinosa Oliva, Ana María; Flores Campos, Rocío; Robles Frías, María José; Álava Casado, Enrique de; Hontecillas Prieto, Lourdes (Springer Nature, 2021)Ewing sarcoma (EWS) is an aggressive bone and soft tissue tumor of children and young adults in which the principal driver ...
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Article
The second European interdisciplinary Ewing sarcoma research summit – A joint effort to deconstructing the multiple layers of a complex disease
Kovar, Heinrich; Amatruda, James; Brunet, Erika; Burdach, Stefan; Cidre-Aranaz, Florencia; Álava Casado, Enrique de (Impact Journals LLC, 2016-01-18)Despite multimodal treatment, long term outcome for patients with Ewing sarcoma is still poor. The second “European ...