Browsing by Author "Álava Casado, Enrique de"
Now showing items 1-20 of 36
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Article
An inducible ectopic expression system of EWSR1-FLI1 as a tool for understanding Ewing sarcoma oncogénesis
(Public Library of Science, 2020)The presence of the chimeric EWSR1-FLI1 oncoprotein is the main and initiating event defining Ewing sarcoma (ES). The ...
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Article
An international working group consensus report for the prioritization of molecular biomarkers for Ewing sarcoma
(Nature Research, 2022-09-17)The advent of dose intensified interval compressed therapy has improved event-free survival for patients with localized ...
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Article
Both Epimutations and Chromosome Aberrations Affect Multiple Imprinted Loci in Aggressive Wilms Tumors
(MDPI, 2020)The embryonal renal cancer Wilms tumor (WT) accounts for 7% of all children’s malignancies. Its most frequent molecular ...
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Article
Breakthrough Technologies Reshape the Ewing Sarcoma Molecular Landscape
(MDPI, 2020)Ewing sarcoma is a highly aggressive round cell mesenchymal neoplasm, most often occurring in children and young adults. ...
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Article
Characterizing the invasive tumor front of aggressive uterine adenocarcinoma and leiomyosarcoma
(Frontiers Media, 2021)The invasive tumor front (the tumor–host interface) is vitally important in malignant cell progression and metastasis. ...
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Article
Ciclos de mejora docente integrados en Anatomía Patológica: ¿primer paso hacia una enseñanza integrada?
(Universidad de Sevilla, 2018)Nuestra hipótesis es que el aprendizaje de los alumnos mejoraría si se integrasen contenidos de diversas asignaturas y ...
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Article
Clinical performance evaluation of the Idylla (TM) EGFR Mutation Test on formalin-fixed paraffin-embedded tissue of non-small cell lung cáncer
(BMC, 2020)Background: Detection of epidermal growth factor receptor (EGFR) mutations in exons 18-21 is recommended in all patients ...
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Article
Endoglin and MMP14 Contribute to Ewing Sarcoma Spreading by Modulation of Cell–Matrix Interactions
(MDPI ; MDPI AG, 2022)Abstract: Endoglin (ENG) is a mesenchymal stem cell (MSC) marker typically expressed by active endothelium. This transmembrane ...
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PhD Thesis
Endoglin in Ewing sarcoma: from the biological relevance to a clinical strategy
(2021-06-11)Endoglin (ENG) is a mesenchymal stem cell (MSC) marker highly expressed mainly in active endothelium and certain cancer ...
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Article
Endoglin in the spotlight to treat cáncer
(MDPI, 2021-03-20)A spotlight has been shone on endoglin in recent years due to that fact of its potential to serve as both a reliable disease ...
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Article
Epithelioid hemangioendothelioma, an ultra-rare cancer: a consensus paper from the community of experts
(Elsevier, 2021)Epithelioid hemangioendothelioma (EHE) is an ultra-rare, translocated, vascular sarcoma. EHE clinical behavior is variable, ...
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PhD Thesis
Estudio de los coactivadores transcripcionales TAZ y YAP1 en el sarcoma de Ewing: Implicación en la progresión tumoral e interacción funcional con la proteína de fusión EWS-FLI1
(2019-10-02)La presente tesis doctoral aborda, por primera vez, el papel funcional de los dos efectores finales de la vía Hippo, TAZ ...
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Article
Evaluation of NAB2-STAT6 Fusion Variants and Other Molecular Alterations as Prognostic Biomarkers in a Case Series of 83 Solitary Fibrous Tumors
(MDPI, 2021-10-19)Risk stratification of solitary fibrous tumor (SFT) patients based on clinicopathological features has limited efficacy, ...
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Article
Ewing Sarcoma Meets Epigenetics, Immunology and Nanomedicine: Moving Forward into Novel Therapeutic Strategies
(MDPI, 2022-11-07)Ewing Sarcoma (EWS) is an aggressive bone and soft tissue tumor that mainly affects children, adolescents, and young adults. ...
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Article
Ewing Sarcoma—Diagnosis, Treatment, Clinical Challenges and Future Perspectives
(MDPI, 2021-04-14)Ewing sarcoma, a highly aggressive bone and soft-tissue cancer, is considered a prime example of the paradigms of a ...
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Article
From precision medicine to imprecision medicine through limited diagnostic ability to detect low allelic frequency mutations
(2020)Routine molecular testing in NSCLC is currently moving beyond the classical EGFR mutational analysis and the evolving ...
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Article
Genetic alterations and deregulation of hippo pathway as a pathogenetic mechanism in bone and soft tissue sarcoma
(MDPI, 2022)The Hippo pathway is an evolutionarily conserved modulator of developmental biology with a key role in tissue and organ ...
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Article
Hippo pathway effectors YAP1/TAZ induce an EWS-FLI1-opposing gene signature and associate with disease progression in Ewing sarcoma
(Wiley, 2020)YAP1 and TAZ (WWTR1) oncoproteins are thefinal transducers of the Hippo tumor suppressor pathway. Deregula-tion of the ...
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Article
HMGA2 overexpression predicts relapse susceptibility of blastemal Wilms tumor patients
(Impact Journals, 2017)Wilms tumor (WT) is an embryonal malignant neoplasm of the kidney that accounts for 6–7% of all childhood cancers. WT ...
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Article
Integrin alpha9 emerges as a key therapeutic target to reduce metastasis in rhabdomyosarcoma and neuroblastoma
(Springer, 2022-10-11)The majority of current cancer therapies are aimed at reducing tumour growth, but there is lack of viable pharmacological ...