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Listar por autor "González Cuesta, Manuel"
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Artículo
Carbohydrate supramolecular chemistry: beyond the multivalent effect
González Cuesta, Manuel; Ortiz Mellet, Carmen; García Fernández, José Manuel (Royal Society of Chemistry, 2020)It has been amply constated that sugar ligand multivalency increases lectin-binding avidities dramatically, thereby ...
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Artículo
High-Mannose Oligosaccharide Hemimimetics that Recapitulate the Conformation and Binding Mode to Concanavalin A, DC-SIGN and Langerin
Herrera González, Irene; González Cuesta, Manuel; Thépaut, Michel; Laigre, Eugénie; Goyard, David; Rojo, Javier; García Fernández, José Manuel; Ortiz Mellet, Carmen (Wiley, 2023-10-12)The “carbohydrate chemical mimicry” exhibited by sp2-iminosugars has been utilized to develop practical syntheses for ...
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Artículo
Multivalent glycoligands with lectin/enzyme dual specificity: self-deliverable glycosidase regulators
González Cuesta, Manuel; Goyard, David; Nanba, Eiji; Higaki, Katsumi; García Fernández, José Manuel; Renaudet, Olivier; Ortiz Mellet, Carmen (Royal Society of Chemistry, 2019)Multivalent mannosides with inherent macrophage recognition abilities, built on β-cyclodextrin, RAFT cyclopeptide or peptide ...
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Tesis Doctoral
Nuevas estrategias para el estudio y tratamiento de enfermedades neurodegenerativas, la regulación del sistema inmune y el transporte de ácidos nucleicos basadas en carbohidratos
González Cuesta, Manuel (2022-06-17)En esta tesis se abordan diferentes aspectos de la química supramolecuar de los carbohidratos con el objetivo general de ...
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Artículo
Serine-/Cysteine-based sp2-Iminoglycolipids as novel TLR4 agonists: evaluation of their adjuvancy and immunotherapeutic properties in a murine model of asthma
González Cuesta, Manuel; Lai, Alan Chuan Ying; Chi, Po Yu; Hsu, I. Ling; Liu, Nien Tzu; Wu, Ko Chien; García Fernández, José Manuel; Ortiz Mellet, Carmen (American Chemical Society, 2023)Glycolipids with TLR4 agonistic properties can serve either as therapeutic agents or as vaccine adjuvants by stimulating ...
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sp2-Iminosugars targeting human lysosomal β-hexosaminidase as pharmacological chaperone candidates for late-onset Tay-Sachs disease
González Cuesta, Manuel; Herrera González, Irene; García Moreno, M. Isabel; Ashmus, Roger A.; Vocadlo, David J.; García Fernández, José Manuel; Nanba, Eiji; Higaki, Katsumi; Ortiz Mellet, Carmen (Taylor & Francis, 2022)The late-onset form of Tay-Sachs disease displays when the activity levels of human β-hexosaminidase A (HexA) fall below ...
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Stereoselective Synthesis of Nojirimycin α-C-Glycosides from a Bicyclic Acyliminium Intermediate: A Convenient Entry to N,C-Biantennary Glycomimetics
Herrera González, Irene; González Cuesta, Manuel; García Moreno, M. Isabel; García Fernández, José Manuel; Ortiz Mellet, Carmen (American Chemical Society, 2022)A simple and efficient method for the stereoselective synthesis of nojirimycin α-C-glycoside derivatives has been developed ...
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Artículo
Trifaceted Mickey Mouse Amphiphiles for Programmable Self-Assembly, DNA Complexation and Organ-Selective Gene Delivery
Carbajo Gordillo, Ana Isabel; González Cuesta, Manuel; Jiménez Blanco, José Luis; Benito, Juan M.; Santana, María L.; Carmona, Thais; Ortiz Mellet, Carmen; García Fernández, José Manuel (Wiley, 2021)Instilling segregated cationic and lipophilic domains with an angular disposition in a trehalose-based trifaceted macrocyclic ...